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| | CDC73 | Cdc73p. (370 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa) |
| | EAF7 | Chromatin modification-related protein EAF7; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (445 aa) |
| | BRE1 | E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (681 aa) |
| | SGF11 | SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (120 aa) |
| | DOT1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (1343 aa) |
| | SET5 | Potential protein lysine methyltransferase SET5; Putative protein lysine methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily. (473 aa) |
| | VID21 | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (686 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa) |
| | NOP1 | rRNA methyltransferase. (316 aa) |
| | CaO19.3581 | WD_REPEATS_REGION domain-containing protein. (435 aa) |
| | CaO19.3613 | Uncharacterized protein. (467 aa) |
| | SET2 | Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (844 aa) |
| | ADA2 | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa) |
| | SET6 | Set6p. (379 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (413 aa) |
| | IPL1 | Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa) |
| | HAT2 | Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa) |
| | CaO19.6694 | Bromo domain-containing protein. (659 aa) |
| | EAF6 | Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (211 aa) |
| | GCN5 | Histone acetyltransferase. (449 aa) |
| | SWD2 | WD-repeat containing protein. (364 aa) |
| | CaO19.268 | Uncharacterized protein. (447 aa) |
| | CaO19.6952 | Uncharacterized protein. (669 aa) |
| | TAF60 | Taf60p. (519 aa) |
| | NAT4 | Nat4p. (203 aa) |
| | CaO19.1259 | DNA-binding E3 ubiquitin-protein ligase. (1443 aa) |
| | CaO19.3084 | SAS4 domain-containing protein. (293 aa) |
| | CaO19.1111 | Chromatin modification protein. (231 aa) |
| | SDC1 | Sdc1p. (128 aa) |
| | CaO19.132 | Uncharacterized protein. (593 aa) |
| | TRA1 | Histone acetyltransferase; Belongs to the PI3/PI4-kinase family. (3821 aa) |
| | SWD3 | Swd3p. (383 aa) |
| | CaO19.7116 | Uncharacterized protein. (317 aa) |
| | CaO19.7074 | SGF29 C-terminal domain-containing protein. (265 aa) |
| | CaO19.7067 | Uncharacterized protein. (1091 aa) |
| | CaO19.6506 | PHD-type domain-containing protein. (688 aa) |
| | UME1 | Ume1p. (485 aa) |
| | NGS1 | Ngs1p. (963 aa) |
| | SAS3 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (805 aa) |
| | RPD3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa) |
| | NAT5 | Peptide alpha-N-acetyltransferase subunit. (175 aa) |
| | CaO19.551 | Uncharacterized protein. (552 aa) |
| | CaO19.3863 | SET domain-containing protein. (630 aa) |
| | CaO19.457 | Ubiquitin-specific protease; Belongs to the peptidase C19 family. (1304 aa) |
| | CaO19.1856 | Uncharacterized protein. (340 aa) |
| | CaO19.7344 | Uncharacterized protein. (835 aa) |
| | SPT7 | SAGA histone acetyltransferase complex subunit. (1307 aa) |
| | ASF1 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (247 aa) |
| | YAF9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (254 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa) |
| | SPT3 | Transcriptional regulator. (328 aa) |
| | HOS2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa) |
| | CaO19.1767 | Ubiquitin carboxyl-terminal hydrolase. (613 aa) |
| | PHO23 | Chromatin modification-related protein. (481 aa) |
| | CaO19.3625 | Uncharacterized protein. (349 aa) |
| | RXT3 | Rxt3p. (517 aa) |
| | TAF14 | TATA-binding protein-associated factor. (263 aa) |
| | CaO19.808 | Rpd3L histone deacetylase complex subunit. (610 aa) |
| | ACT1 | Actin. (376 aa) |
| | TAF145 | Taf145p. (1260 aa) |
| | CaO19.446 | Uncharacterized protein. (297 aa) |
| | CaO19.3027 | Uncharacterized protein; Belongs to the actin family. (378 aa) |
| | SWD1 | COMPASS subunit protein. (447 aa) |
| | CaO19.3661 | Putative ubiquitin-specific protease; Belongs to the peptidase C19 family. (824 aa) |
| | SIN3 | Transcriptional regulator. (1411 aa) |
| | CaO19.4615 | RXT2_N domain-containing protein. (318 aa) |
| | CaO19.4617 | Peptide alpha-N-acetyltransferase. (178 aa) |
| | ASH2 | Ash2p. (466 aa) |
| | SPP1 | Spp1p. (406 aa) |
| | NGG1 | Histone acetyltransferase. (627 aa) |
| | YNG2 | Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (298 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa) |
| | SUS1 | Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (119 aa) |
| | RPD31 | Histone deacetylase. (577 aa) |
| | SAS2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa) |
| | ARP4 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (468 aa) |
| | TEL1 | Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2873 aa) |
| | SET1 | Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1040 aa) |
| | RTT109 | Histone acetyltransferase RTT109; Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. Required for efficient pathogenesis in mice suggesting that efficient DNA repair is required for pathogenesis. Plays an important role in the regulation of white-opaque genotoxin induced-switching; Belongs to the RTT109 family. (359 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa) |
| | EPL1 | Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (753 aa) |
| | HDA1 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa) |
| | SKI8 | SKI complex subunit WD repeat protein. (384 aa) |
| | CaO19.3242 | Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (244 aa) |
