node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CaO19.652 | DNA2 | A0A1D8PSW4 | A0A1D8PPB3 | Crossover junction endodeoxyribonuclease. | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. | 0.707 |
CaO19.652 | SLX1 | A0A1D8PSW4 | Q5A4X4 | Crossover junction endodeoxyribonuclease. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.603 |
DNA2 | CaO19.652 | A0A1D8PPB3 | A0A1D8PSW4 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. | Crossover junction endodeoxyribonuclease. | 0.707 |
DNA2 | EXO1 | A0A1D8PPB3 | A0A1D8PMZ2 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. | Rad2 family nuclease. | 0.984 |
DNA2 | RAD27 | A0A1D8PPB3 | Q5A6K8 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.981 |
DNA2 | SLX1 | A0A1D8PPB3 | Q5A4X4 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.821 |
EXO1 | DNA2 | A0A1D8PMZ2 | A0A1D8PPB3 | Rad2 family nuclease. | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. | 0.984 |
EXO1 | RAD27 | A0A1D8PMZ2 | Q5A6K8 | Rad2 family nuclease. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.897 |
EXO1 | SLX1 | A0A1D8PMZ2 | Q5A4X4 | Rad2 family nuclease. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.903 |
RAD27 | DNA2 | Q5A6K8 | A0A1D8PPB3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. | 0.981 |
RAD27 | EXO1 | Q5A6K8 | A0A1D8PMZ2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Rad2 family nuclease. | 0.897 |
RAD27 | SLX1 | Q5A6K8 | Q5A4X4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.670 |
SLX1 | CaO19.652 | Q5A4X4 | A0A1D8PSW4 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | Crossover junction endodeoxyribonuclease. | 0.603 |
SLX1 | DNA2 | Q5A4X4 | A0A1D8PPB3 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. | 0.821 |
SLX1 | EXO1 | Q5A4X4 | A0A1D8PMZ2 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | Rad2 family nuclease. | 0.903 |
SLX1 | RAD27 | Q5A4X4 | Q5A6K8 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.670 |