STRINGSTRING
CaO19.4533 CaO19.4533 CDC73 CDC73 RPL6 RPL6 RPS27A RPS27A CaO19.2436 CaO19.2436 RPS14B RPS14B CSI2 CSI2 CaO19.6347 CaO19.6347 CaO19.6356 CaO19.6356 CaO19.7265 CaO19.7265 CaO19.2112 CaO19.2112 RPL38 RPL38 PRP39 PRP39 CaO19.1547 CaO19.1547 CaO19.1578 CaO19.1578 A0A1D8PH20 A0A1D8PH20 RPB4 RPB4 CaO19.6886 CaO19.6886 SMD2 SMD2 CaO19.35 CaO19.35 CaO19.82 CaO19.82 CaO19.2260 CaO19.2260 RPS15 RPS15 RPS19A RPS19A MDN1 MDN1 HIT1 HIT1 CaO19.3792 CaO19.3792 CaO19.3779 CaO19.3779 CaO19.2893 CaO19.2893 CaO19.3098 CaO19.3098 TIF5 TIF5 A0A1D8PNM3 A0A1D8PNM3 PRP22 PRP22 CaO19.4029 CaO19.4029 A0A1D8PPC8 A0A1D8PPC8 CaO19.131 CaO19.131 TIF3 TIF3 CaO19.688 CaO19.688 RPL25 RPL25 CaO19.3473 CaO19.3473 NIP7 NIP7 RPS28B RPS28B RTF1 RTF1 RPP0 RPP0 LSM4 LSM4 SUI3 SUI3 CaO19.2818 CaO19.2818 ARC1 ARC1 CaO19.494 CaO19.494 RPS27 RPS27 A0A1D8PTL2 A0A1D8PTL2 WAL1 WAL1 SSF1 SSF1 CaO19.7646 CaO19.7646 CaO19.7673 CaO19.7673 RPS0 RPS0 TIF6 TIF6 RPL3 RPL3 DBP2 DBP2 NOC2 NOC2 CaO19.5206 CaO19.5206 SMD3 SMD3 YHC1 YHC1 RPG1A RPG1A ISY1 ISY1 CaO19.4164 CaO19.4164 RSA3 RSA3 CWC2 CWC2 ESF2 ESF2 CaO19.2230 CaO19.2230 RPF2 RPF2 TIF35 TIF35 CaO19.5835 CaO19.5835 RVB1 RVB1 EXM2 EXM2 CaO19.2920 CaO19.2920 PRP8 PRP8 REX4 REX4 TIF11 TIF11 FUN12 FUN12 CaO19.5465 CaO19.5465 PWP2 PWP2 KIN28 KIN28 MRT4 MRT4 DRS1 DRS1 HCR1 HCR1 NOP13 NOP13 CaO19.6748 CaO19.6748 CLF1 CLF1 CaO19.259 CaO19.259 CaO19.2675 CaO19.2675 RPS5 RPS5 GCD11 GCD11 PRT1 PRT1 RPL5 RPL5 RVB2 RVB2 TIF34 TIF34 RPL10 RPL10 CaO19.4018 CaO19.4018 SPT5 SPT5 NIP1 NIP1 MAK21 MAK21 CaO19.4724 CaO19.4724
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.4533Uncharacterized protein. (505 aa)
CDC73Cdc73p. (370 aa)
RPL660S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family. (176 aa)
RPS27A40S ribosomal protein S27. (82 aa)
CaO19.2436Serine/threonine protein kinase. (882 aa)
RPS14BRibosomal 40S subunit protein S14B; Belongs to the universal ribosomal protein uS11 family. (132 aa)
CSI2Csi2p. (292 aa)
CaO19.6347WD_REPEATS_REGION domain-containing protein. (520 aa)
CaO19.6356U4/U6-U5 snRNP complex subunit. (911 aa)
CaO19.7265mRNA splicing protein. (242 aa)
CaO19.2112mRNA splicing protein. (270 aa)
RPL38Ribosomal 60S subunit protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (78 aa)
PRP39Prp39p. (647 aa)
CaO19.1547Polynucleotide 3'-phosphatase. (301 aa)
CaO19.1578Uncharacterized protein. (1722 aa)
A0A1D8PH20Small nuclear ribonucleoprotein G. (74 aa)
RPB4DNA-directed RNA polymerase II subunit. (268 aa)
CaO19.6886Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (416 aa)
SMD2Small nuclear ribonucleoprotein Sm D2. (112 aa)
CaO19.35Protein kinase domain-containing protein. (976 aa)
CaO19.82U4/U6-U5 snRNP complex subunit. (569 aa)
CaO19.2260HIT-type domain-containing protein. (362 aa)
RPS15Ribosomal 40S subunit protein S15; Belongs to the universal ribosomal protein uS19 family. (142 aa)
RPS19ARibosomal 40S subunit protein S19A. (145 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5035 aa)
HIT1Hit1p. (148 aa)
CaO19.3792Uncharacterized protein. (785 aa)
CaO19.3779WD_REPEATS_REGION domain-containing protein. (519 aa)
CaO19.2893mRNA splicing protein. (845 aa)
CaO19.3098ATP-dependent RNA helicase. (1987 aa)
TIF5Translation initiation factor eIF5. (420 aa)
A0A1D8PNM3mRNA splicing protein. (127 aa)
PRP22DEAH-box ATP-dependent RNA helicase. (996 aa)
CaO19.4029WD_REPEATS_REGION domain-containing protein. (415 aa)
A0A1D8PPC8Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (86 aa)
CaO19.131Uncharacterized protein. (224 aa)
TIF3Tif3p. (455 aa)
CaO19.688Mitochondrial 37S ribosomal protein YmS18. (215 aa)
RPL25Ribosomal 60S subunit protein L25; Belongs to the universal ribosomal protein uL23 family. (142 aa)
CaO19.3473Deubiquitination module subunit. (549 aa)
NIP760S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (181 aa)
RPS28BRibosomal 40S subunit protein S28B. (67 aa)
RTF1Rtf1p. (568 aa)
RPP060S acidic ribosomal protein P0; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome t [...] (312 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (130 aa)
SUI3Translation initiation factor eIF2 subunit beta. (281 aa)
CaO19.2818DEAH-box RNA helicase. (1070 aa)
ARC1Arc1p. (369 aa)
CaO19.494RNA-binding snoRNP assembly protein. (581 aa)
RPS2740S ribosomal protein S27. (82 aa)
A0A1D8PTL2Mitochondrial 37S ribosomal protein RSM19; Belongs to the universal ribosomal protein uS19 family. (91 aa)
WAL1Actin-binding protein. (713 aa)
SSF1rRNA-binding ribosome biosynthesis protein. (448 aa)
CaO19.7646Uncharacterized protein. (313 aa)
CaO19.7673Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family. (116 aa)
RPS040S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits; Belongs to the universal ribosomal protein uS2 family. (261 aa)
TIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
RPL3Ribosomal 60S subunit protein L3; Belongs to the universal ribosomal protein uL3 family. (389 aa)
DBP2ATP-dependent RNA helicase DBP2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (562 aa)
NOC2mRNA-binding ribosome synthesis protein. (714 aa)
CaO19.5206Hsp90 cochaperone. (509 aa)
SMD3Small nuclear ribonucleoprotein Sm D3. (106 aa)
YHC1U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (150 aa)
RPG1AEukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (930 aa)
ISY1Pre-mRNA-splicing factor ISY1; Involved in pre-mRNA splicing. (266 aa)
CaO19.4164SUI1 domain-containing protein. (244 aa)
RSA3Ribosome assembly protein 3; Required for efficient biogenesis of the 60S ribosomal subunit. (195 aa)
CWC2Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...] (363 aa)
ESF2Pre-rRNA-processing protein ESF2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family. (320 aa)
CaO19.2230U2 snRNP complex subunit. (119 aa)
RPF2rRNA-binding ribosome biosynthesis protein. (327 aa)
TIF35Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (279 aa)
CaO19.5835Uncharacterized protein. (280 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
EXM2Exm2p. (240 aa)
CaO19.2920Translation machinery-associated protein 20; Involved in translation; Belongs to the TMA20 family. (184 aa)
PRP8U4/U6-U5 snRNP complex subunit. (2416 aa)
REX4RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (285 aa)
TIF11Tif11p; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (154 aa)
FUN12Translation initiation factor eIF5B. (1017 aa)
CaO19.5465mRNA splicing protein. (232 aa)
PWP2SnoRNA-binding rRNA-processing protein. (922 aa)
KIN28TFIIH complex serine/threonine-protein kinase subunit; Belongs to the protein kinase superfamily. (343 aa)
MRT4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (230 aa)
DRS1ATP-dependent RNA helicase DRS1; ATP-binding RNA helicase involved in ribosome assembly. (613 aa)
HCR1Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (285 aa)
NOP13Nop13p. (396 aa)
CaO19.6748Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (328 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (701 aa)
CaO19.259C3H1-type domain-containing protein. (251 aa)
CaO19.2675mRNA-binding U2 snRNP complex subunit. (1094 aa)
RPS5Ribosomal 40S subunit protein S5; Belongs to the universal ribosomal protein uS7 family. (225 aa)
GCD11Translation initiation factor eIF2 subunit gamma. (534 aa)
PRT1Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (739 aa)
RPL5Ribosomal 60S subunit protein L5. (298 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa)
TIF34Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (350 aa)
RPL10Ribosomal 60S subunit protein L10. (220 aa)
CaO19.4018Mitochondrial 37S ribosomal protein RSM7; Belongs to the universal ribosomal protein uS7 family. (251 aa)
SPT5Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (956 aa)
NIP1Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (874 aa)
MAK21RNA-binding ribosome biosynthesis protein. (1066 aa)
CaO19.4724U1-type domain-containing protein. (256 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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