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HHF1 HHF1 ASF1 ASF1 INO80 INO80 EAF3 EAF3 SPT6 SPT6 HTB1 HTB1 HSP90 HSP90 UBC2 UBC2 CaO19.6843 CaO19.6843 CaO19.4801 CaO19.4801 DPB4 DPB4 MCM3 MCM3 GTR1 GTR1 CDC47 CDC47 CaO19.267 CaO19.267 HRT1 HRT1 SUB2 SUB2 CaO19.5651 CaO19.5651 CaO19.2739 CaO19.2739 HOS1 HOS1 CaO19.4301 CaO19.4301 CAC2 CAC2 CaO19.3949 CaO19.3949 TOP1 TOP1 CaO19.3473 CaO19.3473 HHO1 HHO1 YDJ1 YDJ1 CaO19.6625 CaO19.6625 CaO19.3890 CaO19.3890 CSM1 CSM1 CDC46 CDC46 SIR2 SIR2 GLC7 GLC7 CaO19.4615 CaO19.4615 CaO19.4617 CaO19.4617 POB3 POB3 HPC2 HPC2 CDC53 CDC53 CDC34 CDC34 HIR2 HIR2 HTZ1 HTZ1 HIR3 HIR3 CaO19.6726 CaO19.6726 RPD31 RPD31 SAS2 SAS2 HIR1 HIR1 NAP1 NAP1 HST2 HST2 HDA1 HDA1 CaO19.3349 CaO19.3349 ESA1 ESA1 NAM7 NAM7 CDC68 CDC68 MSH2 MSH2 PR26 PR26 CaO19.3581 CaO19.3581 HTB2 HTB2 HAT1 HAT1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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HHF1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
ASF1Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (247 aa)
INO80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1387 aa)
EAF3Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa)
SPT6Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1401 aa)
HTB1Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa)
HSP90Heat shock protein 90 homolog; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family. (707 aa)
UBC2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa)
CaO19.6843SHNi-TPR domain-containing protein. (373 aa)
CaO19.4801tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (465 aa)
DPB4DNA polymerase epsilon noncatalytic subunit. (261 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
GTR1Rag GTPase. (352 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
CaO19.267Cytokin_check_N domain-containing protein. (1213 aa)
HRT1SCF ubiquitin ligase complex subunit. (123 aa)
SUB2ATP-dependent RNA helicase. (433 aa)
CaO19.5651Histone demethylase. (723 aa)
CaO19.2739Uncharacterized protein. (572 aa)
HOS1Histone deacetylase. (436 aa)
CaO19.4301GATA-type domain-containing protein. (814 aa)
CAC2Cac2p. (460 aa)
CaO19.3949Bromo domain-containing protein. (1314 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (780 aa)
CaO19.3473Deubiquitination module subunit. (549 aa)
HHO1Histone. (180 aa)
YDJ1Type I HSP40 co-chaperone. (393 aa)
CaO19.6625Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (275 aa)
CaO19.3890DNA-dependent ATPase. (1097 aa)
CSM1Csm1 domain-containing protein. (225 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
SIR2NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa)
GLC7Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CaO19.4615RXT2_N domain-containing protein. (318 aa)
CaO19.4617Peptide alpha-N-acetyltransferase. (178 aa)
POB3FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (538 aa)
HPC2Hpc2p. (552 aa)
CDC53Cullin; Belongs to the cullin family. (752 aa)
CDC34SCF E2 ubiquitin-protein ligase catalytic subunit; Belongs to the ubiquitin-conjugating enzyme family. (244 aa)
HIR2Protein HIR2; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa)
HIR3Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Belongs to the HIR3 family. (1591 aa)
CaO19.6726Uncharacterized protein. (332 aa)
RPD31Histone deacetylase. (577 aa)
SAS2Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa)
HIR1Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa)
NAP1Nucleosome assembly protein 1; Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis. (435 aa)
HST2NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily. (331 aa)
HDA1Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa)
CaO19.3349DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1234 aa)
ESA1Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa)
NAM7ATP-dependent RNA helicase. (1019 aa)
CDC68FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa)
MSH2Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa)
PR26Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (411 aa)
CaO19.3581WD_REPEATS_REGION domain-containing protein. (435 aa)
HTB2Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (413 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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