STRINGSTRING
CaO19.3643 CaO19.3643 GRF10 GRF10 PPR1 PPR1 CaO19.3928 CaO19.3928 GLN3 GLN3 CTA7 CTA7 LEU3 LEU3 HAL9 HAL9 ORC4 ORC4 ZNC1 ZNC1 TAC1 TAC1 FCR3 FCR3 CaO19.3125 CaO19.3125 CaO19.4420 CaO19.4420 PHO4 PHO4 CSR1 CSR1 CaO19.2730 CaO19.2730 HFL2 HFL2 CaO19.2743 CaO19.2743 HAP3 HAP3 RLM1 RLM1 CaO19.4686 CaO19.4686 CaO19.6718 CaO19.6718 CaO19.7397 CaO19.7397 TEA1 TEA1 A0A1D8PK71 A0A1D8PK71 POL1 POL1 RAD53 RAD53 ZCF16 ZCF16 CaO19.267 CaO19.267 RAD50 RAD50 CaO19.1757 CaO19.1757 GCN4 GCN4 CaO19.1368 CaO19.1368 RAP1 RAP1 CDC47 CDC47 CaO19.1600 CaO19.1600 CaO19.217 CaO19.217 STN1 STN1 MCM3 MCM3 CaO19.3146 CaO19.3146 CaO19.5210 CaO19.5210 ADAEC ADAEC SNF2 SNF2 OFI1 OFI1 CDC54 CDC54 CDC6 CDC6 CAS1 CAS1 RTG3 RTG3 CaO19.4911 CaO19.4911 PDC2 PDC2 CaO19.4768 CaO19.4768 ZCF28 ZCF28 TERT TERT CaO19.4437 CaO19.4437 CaO19.3035 CaO19.3035 ZCF24 ZCF24 HOT1 HOT1 TRI1 TRI1 RPO41 RPO41 CTA8 CTA8 RTG1 RTG1 HCM1 HCM1 SFU1 SFU1 WOR1 WOR1 SBP1 SBP1 TEC1 TEC1 STP3 STP3 SEN1 SEN1 TRY4 TRY4 CAS5 CAS5 SMP2 SMP2 HSK3 HSK3 CaO19.1577 CaO19.1577 CaO19.4918 CaO19.4918 TYE7 TYE7 STP2 STP2 CUP2 CUP2 CaO19.5026 CaO19.5026 ASH2 ASH2 SFL2 SFL2 CAP1 CAP1 CDC53 CDC53 TBF1 TBF1 STP4 STP4 CUP9 CUP9 MCM1 MCM1 MAC1 MAC1 ADR1 ADR1 HTZ1 HTZ1 CLF1 CLF1 SSN6 SSN6 RFA1 RFA1 RBF1 RBF1 CDC5 CDC5 CaO19.6090 CaO19.6090 RCA1 RCA1 PUT3 PUT3 CaO19.2473 CaO19.2473 CaO19.3289 CaO19.3289 FKH2 FKH2 CaO19.5390 CaO19.5390 EST3 EST3 CaO19.5429 CaO19.5429 CAT8 CAT8 HAP31 HAP31 PIM1 PIM1 BAS1 BAS1 MET4 MET4 CaO19.5326 CaO19.5326 ASH1 ASH1 CaO19.5358 CaO19.5358 DBF4 DBF4 SKN7 SKN7 TRY5 TRY5 CRZ1 CRZ1 AHR1 AHR1 GAT1 GAT1 SFL1 SFL1 RFG1 RFG1 GZF3 GZF3 NCB2 NCB2 CaO19.5841 CaO19.5841 NRG1 NRG1 MCM2 MCM2 FHL1 FHL1 RFA2 RFA2 EFG1 EFG1 ADA2 ADA2 SKP1 SKP1 RME1 RME1 CaO19.4441 CaO19.4441 ZCF23 ZCF23 SKO1 SKO1 WAR1 WAR1 RPN4 RPN4 RFX1 RFX1 SEF1 SEF1 SWI1 SWI1 CaO19.5676 CaO19.5676 SLD2 SLD2 CaO19.1897 CaO19.1897 BCR1 BCR1 CaO19.1150 CaO19.1150 ZCF3 ZCF3 MED8 MED8 CaO19.4537 CaO19.4537 CaO19.6874 CaO19.6874 ORC3 ORC3 CRZ2 CRZ2 CaO19.2369 CaO19.2369 STB3 STB3 CaO19.211 CaO19.211 MNL1 MNL1 ACE2 ACE2 CaO19.29 CaO19.29 HMO1 HMO1 CDC46 CDC46 EFH1 EFH1 MRR2 MRR2 CWT1 CWT1 BRG1 BRG1 CSE4 CSE4 RRN3 RRN3 PZF1 PZF1 TDS4 TDS4 HSP60 HSP60 TBP1 TBP1 CDC45 CDC45 CaO19.2624 CaO19.2624 SPT10 SPT10 RRN11 RRN11 CaO19.551 CaO19.551 YKU80 YKU80 CIRT4B CIRT4B CaO19.173 CaO19.173 CaO19.3722 CaO19.3722 MCM6 MCM6 ZCF38 ZCF38 ZCF29 ZCF29 CaO19.6499 CaO19.6499 CaO19.6921 CaO19.6921 MRE11 MRE11 YOX1 YOX1 CaO19.7088 CaO19.7088 CaO19.7101 CaO19.7101 TSM1 TSM1 POL5 POL5 MIF2 MIF2 CaO19.3644 CaO19.3644 CaO19.1189 CaO19.1189
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.3643Uncharacterized protein. (390 aa)
GRF10Grf10p. (685 aa)
PPR1Ppr1p. (860 aa)
CaO19.3928Uncharacterized protein. (380 aa)
GLN3Nitrogen-responsive transcriptional regulator. (682 aa)
CTA7Cta7p. (834 aa)
LEU3Leucine-responsive transcriptional regulator. (984 aa)
HAL9Hal9p. (1010 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa)
ZNC1Znc1p. (922 aa)
TAC1Tac1p. (981 aa)
FCR3Fcr3p. (399 aa)
CaO19.3125Uncharacterized protein. (258 aa)
CaO19.4420Uncharacterized protein. (800 aa)
PHO4Phosphate-sensing transcription factor. (659 aa)
CSR1Csr1p. (618 aa)
CaO19.2730Uncharacterized protein. (606 aa)
HFL2Negative cofactor 2 transcription regulator complex subunit. (146 aa)
CaO19.2743Uncharacterized protein. (606 aa)
HAP3Hap3p. (329 aa)
RLM1Rlm1p. (601 aa)
CaO19.4686PINc domain-containing protein. (1200 aa)
CaO19.6718Uncharacterized protein. (250 aa)
CaO19.7397C2H2-type domain-containing protein. (1089 aa)
TEA1Tea1p. (900 aa)
A0A1D8PK71HABP4_PAI-RBP1 domain-containing protein. (267 aa)
POL1DNA polymerase. (1470 aa)
RAD53Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa)
ZCF16Zcf16p. (1078 aa)
CaO19.267Cytokin_check_N domain-containing protein. (1213 aa)
RAD50MRX complex DNA-binding subunit. (1332 aa)
CaO19.1757Uncharacterized protein. (583 aa)
GCN4Amino acid starvation-responsive transcription factor. (323 aa)
CaO19.1368Uncharacterized protein. (607 aa)
RAP1DNA-binding transcription factor. (430 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
CaO19.1600Uncharacterized protein. (709 aa)
CaO19.217Uncharacterized protein. (379 aa)
STN1Stn1p. (587 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
CaO19.3146Uncharacterized protein. (416 aa)
CaO19.5210HTH APSES-type domain-containing protein. (577 aa)
ADAECAdaecp. (545 aa)
SNF2SWI/SNF catalytic subunit. (1690 aa)
OFI1Ofi1p. (648 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
CDC6Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa)
CAS1ATP-dependent DNA helicase. (811 aa)
RTG3Rtg3p. (520 aa)
CaO19.4911BED-type domain-containing protein. (320 aa)
PDC2Pdc2p. (836 aa)
CaO19.4768Uncharacterized protein. (531 aa)
ZCF28Zcf28p. (247 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (867 aa)
CaO19.4437Chromatin-remodeling ATPase. (1017 aa)
CaO19.3035Chromatin-remodeling ATPase. (1410 aa)
ZCF24Zcf24p. (701 aa)
HOT1GCR1_C domain-containing protein. (607 aa)
TRI1SWIB domain-containing protein. (252 aa)
RPO41DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1300 aa)
CTA8Heat shock transcription factor; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. With HSP90, is required for the modulation of the chaperone levels in response to growth temperature, rather than the activation of acute responses to sudden thermal transitions. Activated during infection and contributes to full virulence. Belongs to the HSF family. (760 aa)
RTG1Rtg1p. (274 aa)
HCM1Hcm1p. (579 aa)
SFU1Suppressor of ferric uptake 1; Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice. (517 aa)
WOR1White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...] (785 aa)
SBP1Sbp1p. (282 aa)
TEC1Transcription activator TEC1; Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tub [...] (743 aa)
STP3Transcriptional regulator STP3; Transcription factor that activates genes required for degradation of extracellular protein and uptake of peptides such as the secreted aspartyl protease SAP2 or the oligopeptide transporter OPT1. Required for virulence. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. (436 aa)
SEN1Putative DNA/RNA helicase. (2018 aa)
TRY4Transcriptional regulator of yeast form adherence 4; Transcription factor required for yeast cell adherence to silicone substrate. (286 aa)
CAS5Cell wall integrity transcriptional regulator CAS5; Transcription factor involved in the cell wall damage response. Acts with ADA2 to promote cell wall integrity. Required for expression of numerous cell wall biosynthesis inhibitor caspofungin- responsive genes. Plays a key role in adherence, hyphal development, and virulence. (821 aa)
SMP2Phosphatidate phosphatase. (781 aa)
HSK3Hsk3p. (106 aa)
CaO19.1577GATA-type domain-containing protein. (442 aa)
CaO19.4918HTH CENPB-type domain-containing protein. (519 aa)
TYE7Carbohydrate metabolism regulator TYE7; Key transcriptional regulator of carbohydrate metabolism. Binds the promoter sequences of the glycolytic genes at the CANNTG motif and activates their expression during growth on either fermentable or non-fermentable carbon sources as well as under hypoxic growth conditions. Complete glycolytic activation by GAL4 and TYE7 is required for full virulence. Involved in biofilm formation and negatively regulates hyphal formation under hypoxia. Controls also the expression of the copper transport protein CTR1. (269 aa)
STP2Transcriptional regulator STP2; Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyph [...] (584 aa)
CUP2Cup2p. (591 aa)
CaO19.5026Uncharacterized protein. (1177 aa)
ASH2Ash2p. (466 aa)
SFL2Transcription factor SFL2; Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature. Required for human oral epithelium colonization and damage. Promotes filamentous growth in EFG1- and FLO8-dependent manners. Antagonizes functions of SFL1. Belongs to the HSF family. (714 aa)
CAP1AP-1-like transcription factor CAP1; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Involved in the oxidative stress response in via multiple pathways, including the cellular antioxidant defense system, carbohydrate metabolism and energy metabolism, protein degradation, ATP-dependent RNA helicase, and resistance pathways. The ability of the major systemic fungal pathogen of humans to sense and respond to reactive oxygen species, such as H(2)O(2) ge [...] (499 aa)
CDC53Cullin; Belongs to the cullin family. (752 aa)
TBF1Transcription factor TBF1; Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci. Recruits FHL1 and IFH1 to promoters. (886 aa)
STP4Transcriptional regulator STP4; Probable transcription factor involved in response to cell wall damage. (376 aa)
CUP9Cup9p. (344 aa)
MCM1Transcription factor of morphogenesis MCM1; Transcription factor that is recruited by AHR1 to the promoters of genes involved in biofilm formation, which include several key adhesion genes. Plays an important role in cell adhesion, hyphal growth and virulence. Implicated in the regulation of opaque-phase- specific gene expression. (262 aa)
MAC1Metal-binding activator 1; Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth. (431 aa)
ADR1Transcriptional regulator ADR1; Transcription factor involved in the regulation of hyphal growth. (1418 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (701 aa)
SSN6Transcription regulator. (1080 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
RBF1Transcription factor RBF1; Transcriptional activator that binds to the RPG box and to telomeres. Involved in the regulation of the transition between yeast and filamentous forms and plays a role in virulence. Induces expression of HWP1, a major hyphal cell protein and virulence factor. Belongs to the RBF1 family. (534 aa)
CDC5Serine/threonine-protein kinase. (653 aa)
CaO19.6090Uncharacterized protein. (400 aa)
RCA1Rca1p. (283 aa)
PUT3Put3p. (978 aa)
CaO19.2473RFX-type winged-helix domain-containing protein. (634 aa)
CaO19.3289Origin recognition complex subunit 6. (363 aa)
FKH2Fork-head transcriptional regulator 2; Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence. (687 aa)
CaO19.5390Uncharacterized protein. (147 aa)
EST3Telomere replication protein EST3; Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity). (210 aa)
CaO19.5429DNA-binding SCF ubiquitin ligase subunit. (675 aa)
CAT8DNA-binding transcription factor. (1056 aa)
HAP31Hap31p. (105 aa)
PIM1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1078 aa)
BAS1Bas1p. (738 aa)
MET4Met4p. (385 aa)
CaO19.5326Uncharacterized protein. (269 aa)
ASH1Transcriptional regulatory protein ASH1; Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis. (449 aa)
CaO19.5358Origin recognition complex subunit 2. (688 aa)
DBF4Protein serine/threonine kinase activating protein. (506 aa)
SKN7Transcription factor SKN7; Transcription factor that is part of a SLN1-YPD1-SKN7 two- component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes. (559 aa)
TRY5Transcriptional regulator of yeast form adherence 5; Transcription factor required for yeast cell adherence to silicone substrate. (988 aa)
CRZ1Transcriptional regulator CRZ1; Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity. Binds to the calcineurin-dependent response element. Plays a role in azole tolerance. (731 aa)
AHR1Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state. (624 aa)
GAT1Transcriptional regulatory protein GAT1; Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model. (688 aa)
SFL1Transcription factor SFL1; Transcription factor that plays a role of repressor of filamentous growth and flocculation. Antagonizes functions of SFL2 and FLO8. Plays a role in the hyphal repression induced by secreted factors like dodecanol by competitors such as Pseudomonas aeruginosa and Burkholderia cenocepacia. (805 aa)
RFG1Repressor of filamentous growth 1; Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5. (600 aa)
GZF3Transcriptional regulator GZF3; Probable transcription factor involved in response to fluconazole, LiCl, and copper. (712 aa)
NCB2Negative cofactor 2 transcription regulator complex subunit. (149 aa)
CaO19.5841Uncharacterized protein. (252 aa)
NRG1Transcriptional regulator NRG1; Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament- specific gene expression in r [...] (310 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
FHL1Fork-head transcriptional regulator FHL1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1. (1152 aa)
RFA2Rfa2p. (272 aa)
EFG1Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] (550 aa)
ADA2Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa)
SKP1SCF ubiquitin ligase subunit; Belongs to the SKP1 family. (164 aa)
RME1Rme1p. (507 aa)
CaO19.4441Zf-primase domain-containing protein. (598 aa)
ZCF23Glucose starvation modulator protein 1; Transcription factor which regulates nonfermentable carbon utilization; Belongs to the ERT1/acuK family. (566 aa)
SKO1Transcriptional regulator SKO1; Transcription repressor involved in cell wall damage response. Regulates 79 caspofungin-responsive genes, including several cell wall biogenesis genes such as CRH11, MNN2, and SKN1. Controls also the expression of pathogenesis and hyphal related genes and represses the yeast-to-hypha transition. Mediates the response to oxidative stress. (578 aa)
WAR1Transcriptional regulator WAR1; Transcription factor required for yeast cell adherence to silicone substrate. Plays a role in resistance to weak organic acids such as acetate and sorbate. Binds in vitro to a nitric oxide- responsive element (NORE) but seems not to be involved in response to nitrosative stress. (947 aa)
RPN4Transcriptional regulator RPN4; Transcriptional activator of a number of genes encoding proteasomal subunits. Binds to the DNA sequence 5'-GAAGGCAAAA-3', enriched in regions upstream of proteasome genes. (536 aa)
RFX1Transcriptional regulator RFX1; Transcription factor involved in DNA damage responses, morphogenesis, and virulence. (851 aa)
SEF1Transcriptional regulatory protein SEF1; Transcription factor which plays an essential role in virulence by activating the transcription of iron uptake genes such as FRE7 in iron-poor environments such as the host bloodstream and internal organs. Promotes commensalism in a mouse model of gastrointestinal infection. (917 aa)
SWI1Swi1p. (987 aa)
CaO19.5676RING-type domain-containing protein. (603 aa)
SLD2DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa)
CaO19.1897GCR1_C domain-containing protein. (344 aa)
BCR1Biofilm and cell wall regulator 1; Transcription factor which acts as a master regulator of biofilm formation. Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis. Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 AND HYR1. Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation. (740 aa)
CaO19.1150GATA-type domain-containing protein. (472 aa)
ZCF3Zcf3p. (195 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (239 aa)
CaO19.4537Uncharacterized protein. (305 aa)
CaO19.6874Uncharacterized protein. (607 aa)
ORC3Origin recognition complex subunit 3. (682 aa)
CRZ2Transcriptional regulator CRZ2; Transcription factor that regulates pH-induced filamentation with RIM101. Required for yeast cell adherence to silicone substrate and biofilm formation. (517 aa)
CaO19.2369Origin recognition complex subunit 5. (496 aa)
STB3Stb3p. (503 aa)
CaO19.211HTH araC/xylS-type domain-containing protein. (180 aa)
MNL1Transcriptional regulator MNL1; Transcription factor that activates stress response genes via SLE (STRE-like) elements. Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress. Activates a subset of the genes that are repressed by NRG1. (905 aa)
ACE2Cell wall transcription factor ACE2; Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection. (783 aa)
CaO19.29CDT1_C domain-containing protein. (323 aa)
HMO1Transcriptional regulator HMO1; Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth. (223 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
EFH1Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. (720 aa)
MRR2Multidrug resistance regulator 2; Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence. (710 aa)
CWT1Cwt1p. (578 aa)
BRG1Biofilm regulator 1; Transcription factor required for hyphal growth, biofilm formation, and virulence. Promotes formation of both conventional and pheromone-stimulated biofilms. Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner. Involved in the switch between two heritable states, the white and opaque states. These two cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically at low frequency. (422 aa)
CSE4Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (211 aa)
RRN3rDNA-binding RNA polymerase I transcriptional factor. (556 aa)
PZF1Transcription factor IIIA; Transcription factor required for transcription of 5S rRNA by RNA polymerase III. (412 aa)
TDS4Transcription factor IIIB 70 kDa subunit; General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC. (553 aa)
HSP60Heat shock protein 60, mitochondrial; May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity); Belongs to the chaperonin (HSP60) family. (566 aa)
TBP1TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (238 aa)
CDC45DNA replication initiation factor. (579 aa)
CaO19.2624Uncharacterized protein. (607 aa)
SPT10Spt10p. (469 aa)
RRN11Rrn11p. (691 aa)
CaO19.551Uncharacterized protein. (552 aa)
YKU80ATP-dependent DNA helicase. (609 aa)
CIRT4BCirt4bp. (555 aa)
CaO19.173Uncharacterized protein. (1100 aa)
CaO19.3722Uncharacterized protein. (849 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
ZCF38Zcf38p. (582 aa)
ZCF29Zcf29p. (1105 aa)
CaO19.6499DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1218 aa)
CaO19.6921Uncharacterized protein. (772 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa)
YOX1Yox1p. (335 aa)
CaO19.7088Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (382 aa)
CaO19.7101Telomere_reg-2 domain-containing protein. (788 aa)
TSM1Tsm1p. (1425 aa)
POL5DNA-directed DNA polymerase. (1055 aa)
MIF2Mif2p. (520 aa)
CaO19.3644Uncharacterized protein. (715 aa)
CaO19.1189NDC10_II domain-containing protein. (684 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.