STRINGSTRING
TOP2 TOP2 ESP1 ESP1 REC8 REC8 CaO19.5053 CaO19.5053 DLH1 DLH1 CDC7 CDC7 CaO19.5212 CaO19.5212 RAD1 RAD1 PPH21 PPH21 CaO19.5954 CaO19.5954 CaO19.2713 CaO19.2713 BUB1 BUB1 CaO19.2922 CaO19.2922 MHF1 MHF1 CaO19.3648 CaO19.3648 MIF2 MIF2 KIP1 KIP1 CaO19.7594 CaO19.7594 CSM1 CSM1 CDC28 CDC28 MUS81 MUS81 RTS1 RTS1 HRR25 HRR25 IPL1 IPL1 NUF2 NUF2 SGS1 SGS1 CaO19.3306 CaO19.3306 CDC5 CDC5 TPD3 TPD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TOP2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1461 aa)
ESP1Separase. (1598 aa)
REC8Rad21_Rec8_N domain-containing protein. (635 aa)
CaO19.5053Uncharacterized protein. (260 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
CDC7Serine/threonine protein kinase. (656 aa)
CaO19.5212SUMO ligase. (366 aa)
RAD1SsDNA endodeoxyribonuclease. (970 aa)
PPH21Serine/threonine-protein phosphatase. (360 aa)
CaO19.5954WD_REPEATS_REGION domain-containing protein. (510 aa)
CaO19.2713MutS family protein. (802 aa)
BUB1Protein kinase. (900 aa)
CaO19.2922TBPIP domain-containing protein. (205 aa)
MHF1Inner kinetochore subunit MHF1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere- associated network (CCAN), wh [...] (117 aa)
CaO19.3648ERCC4 domain-containing protein. (587 aa)
MIF2Mif2p. (520 aa)
KIP1Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (911 aa)
CaO19.7594Uncharacterized protein. (213 aa)
CSM1Csm1 domain-containing protein. (225 aa)
CDC28Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)
RTS1Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (850 aa)
HRR25Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (433 aa)
IPL1Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa)
NUF2Probable kinetochore protein NUF2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (485 aa)
SGS1ATP-dependent DNA helicase. (1189 aa)
CaO19.3306HORMA domain-containing protein. (607 aa)
CDC5Serine/threonine-protein kinase. (653 aa)
TPD3Protein phosphatase 2A structural subunit. (643 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.