STRINGSTRING
CaO19.4502 CaO19.4502 MAF1 MAF1 ZCF8 ZCF8 TCC1 TCC1 NUP159 NUP159 CaO19.5651 CaO19.5651 SET2 SET2 CaO19.1150 CaO19.1150 HRR25 HRR25 FLO8 FLO8 UPC2 UPC2 EFH1 EFH1 VPS22 VPS22 ESS1 ESS1 MTLA1 MTLA1 URE2 URE2 SFU1 SFU1 CaO19.5930 CaO19.5930 TUP1 TUP1 ZCF32 ZCF32 RFX2 RFX2 SPT5 SPT5 KNS1 KNS1 CDC28 CDC28 CaO19.3942 CaO19.3942 SSN3 SSN3 MED7 MED7 CaO19.6722 CaO19.6722 SSN6 SSN6 RPD31 RPD31 SAS2 SAS2 HIR1 HIR1 SWC4 SWC4 HDA1 HDA1 FKH2 FKH2 ESA1 ESA1 CaO19.5326 CaO19.5326 ASH1 ASH1 GAT1 GAT1 EAF3 EAF3 RFG1 RFG1 GZF3 GZF3 NCB2 NCB2 NRG1 NRG1 FHL1 FHL1 CaO19.7329 CaO19.7329 CaO19.3890 CaO19.3890 CaO19.1856 CaO19.1856 CaO19.3722 CaO19.3722 SAS3 SAS3 CaO19.7527 CaO19.7527 RTF1 RTF1 SWD3 SWD3 CaO19.132 CaO19.132 CaO19.3949 CaO19.3949 GLN3 GLN3 CaO19.6667 CaO19.6667 MIG1 MIG1 LEU3 LEU3 HFL2 HFL2 CaO19.7664 CaO19.7664 RGT1 RGT1 ZCF21 ZCF21 SIN3 SIN3 HAP43 HAP43 RAD23 RAD23 OPI1 OPI1 CaO19.808 CaO19.808
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.4502DNA-binding ATPase. (1915 aa)
MAF1Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (380 aa)
ZCF8Zcf8p. (915 aa)
TCC1Tcc1p. (748 aa)
NUP159FG-nucleoporin. (850 aa)
CaO19.5651Histone demethylase. (723 aa)
SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (844 aa)
CaO19.1150GATA-type domain-containing protein. (472 aa)
HRR25Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (433 aa)
FLO8Transcriptional regulator of filamentous growth FLO8; Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections. (792 aa)
UPC2Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping. (712 aa)
EFH1Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. (720 aa)
VPS22Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (261 aa)
ESS1Peptidyl-prolyl cis-trans isomerase. (177 aa)
MTLA1Mating-type-like protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating. Belongs to the MATA1 family. (210 aa)
URE2Protein URE2; Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity); Belongs to the GST superfamily. (344 aa)
SFU1Suppressor of ferric uptake 1; Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice. (517 aa)
CaO19.5930FG-nucleoporin. (366 aa)
TUP1Transcriptional repressor TUP1; Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of the response to farnesol. Plays an important role in the regulation of white-opaque switching. (512 aa)
ZCF32Zcf32p. (716 aa)
RFX2RFX-like DNA-binding protein RFX2; Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1; Belongs to the RFX family. (1111 aa)
SPT5Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (956 aa)
KNS1Serine/threonine protein kinase. (666 aa)
CDC28Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa)
CaO19.3942ESCRT-II subunit protein. (196 aa)
SSN3Serine/threonine-protein kinase SSN3; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity). (608 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (304 aa)
CaO19.6722Uncharacterized protein. (709 aa)
SSN6Transcription regulator. (1080 aa)
RPD31Histone deacetylase. (577 aa)
SAS2Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa)
HIR1Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa)
SWC4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa)
HDA1Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa)
FKH2Fork-head transcriptional regulator 2; Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence. (687 aa)
ESA1Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa)
CaO19.5326Uncharacterized protein. (269 aa)
ASH1Transcriptional regulatory protein ASH1; Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis. (449 aa)
GAT1Transcriptional regulatory protein GAT1; Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model. (688 aa)
EAF3Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa)
RFG1Repressor of filamentous growth 1; Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5. (600 aa)
GZF3Transcriptional regulator GZF3; Probable transcription factor involved in response to fluconazole, LiCl, and copper. (712 aa)
NCB2Negative cofactor 2 transcription regulator complex subunit. (149 aa)
NRG1Transcriptional regulator NRG1; Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament- specific gene expression in r [...] (310 aa)
FHL1Fork-head transcriptional regulator FHL1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1. (1152 aa)
CaO19.7329E2 ubiquitin-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
CaO19.3890DNA-dependent ATPase. (1097 aa)
CaO19.1856Uncharacterized protein. (340 aa)
CaO19.3722Uncharacterized protein. (849 aa)
SAS3Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (805 aa)
CaO19.7527Uncharacterized protein. (726 aa)
RTF1Rtf1p. (568 aa)
SWD3Swd3p. (383 aa)
CaO19.132Uncharacterized protein. (593 aa)
CaO19.3949Bromo domain-containing protein. (1314 aa)
GLN3Nitrogen-responsive transcriptional regulator. (682 aa)
CaO19.6667SAP30_Sin3_bdg domain-containing protein. (168 aa)
MIG1Transcription factor. (570 aa)
LEU3Leucine-responsive transcriptional regulator. (984 aa)
HFL2Negative cofactor 2 transcription regulator complex subunit. (146 aa)
CaO19.7664zf-LYAR domain-containing protein. (134 aa)
RGT1Rgt1p. (1027 aa)
ZCF21Zcf21p. (629 aa)
SIN3Transcriptional regulator. (1411 aa)
HAP43Hap43p. (634 aa)
RAD23Rad23p. (416 aa)
OPI1Transcriptional regulator. (432 aa)
CaO19.808Rpd3L histone deacetylase complex subunit. (610 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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