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| | RTG1 | Rtg1p. (274 aa) |
| | AFT2 | Iron-regulated transcriptional activator AFT2; Transcription factor involved in iron metabolism, oxidative stress, surface adhesion, hyphal development and virulence. Functions as a negative regulator of MRS4 expression through the CACCC AFT-type sequence in a gene dose-dependent fashion. Acts as a repressor in flocculation, plastic adhesion, and surface hydrophobicity. (798 aa) |
| | RSP5 | E3 ubiquitin-protein ligase. (832 aa) |
| | EFG1 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] (550 aa) |
| | GPX3 | Glutathione peroxidase-like peroxiredoxin GPX3; Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator CAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging. The enzyme is not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, GPX3 is directly oxidized at Cys-43 to form a cysteine sulfenic [...] (171 aa) |
| | CaO19.5666 | Chromatin-binding transcription coactivator. (146 aa) |
| | CaO19.5676 | RING-type domain-containing protein. (603 aa) |
| | CaO19.1897 | GCR1_C domain-containing protein. (344 aa) |
| | CaO19.1150 | GATA-type domain-containing protein. (472 aa) |
| | CaO19.4537 | Uncharacterized protein. (305 aa) |
| | CaO19.6874 | Uncharacterized protein. (607 aa) |
| | STB3 | Stb3p. (503 aa) |
| | CPH2 | Transcription factor CPH2; Transcription factor that positively controls filamentous growth, virulence, and invasiveness. Binds directly to the two SRE-1- like elements upstream of TEC1 and thus regulates positively expression of this important hyphal growth regulator. Functions independently of known signaling cascades involving EFG1. Regulates also gene expression during intestinal colonization but is not involved in host cell adhesion. (853 aa) |
| | UPC2 | Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping. (712 aa) |
| | CaO19.399 | Non-specific serine/threonine protein kinase. (712 aa) |
| | GCN5 | Histone acetyltransferase. (449 aa) |
| | EFH1 | Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. (720 aa) |
| | ASF1 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (247 aa) |
| | MRR2 | Multidrug resistance regulator 2; Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence. (710 aa) |
| | ASG1 | Activator of stress genes protein 1; Transcription factor necessary to sustain growth on non- fermentative carbon sources such as sodium acetate, acetic acid, or ethanol. Plays a role in hyphal formation. (990 aa) |
| | CKS1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (102 aa) |
| | ESS1 | Peptidyl-prolyl cis-trans isomerase. (177 aa) |
| | INO80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1387 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa) |
| | SPT6 | Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1401 aa) |
| | CDC28 | Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa) |
| | UGA3 | Uga3p. (803 aa) |
| | CaO19.6393 | Uncharacterized protein. (417 aa) |
| | CaO19.173 | Uncharacterized protein. (1100 aa) |
| | KAR4 | Kar4p; Belongs to the MT-A70-like family. (369 aa) |
| | SAS3 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (805 aa) |
| | REP1 | Rep1p. (693 aa) |
| | INO2 | Ino2p. (379 aa) |
| | CaO19.7198 | CCR4-NOT core subunit. (331 aa) |
| | ZCF29 | Zcf29p. (1105 aa) |
| | CaO19.7036 | Uncharacterized protein. (426 aa) |
| | MET28 | Met28p. (173 aa) |
| | RTF1 | Rtf1p. (568 aa) |
| | CaO19.7074 | SGF29 C-terminal domain-containing protein. (265 aa) |
| | CaO19.7116 | Uncharacterized protein. (317 aa) |
| | GRF10 | Grf10p. (685 aa) |
| | PPR1 | Ppr1p. (860 aa) |
| | CaO19.3949 | Bromo domain-containing protein. (1314 aa) |
| | GLN3 | Nitrogen-responsive transcriptional regulator. (682 aa) |
| | CaO19.1111 | Chromatin modification protein. (231 aa) |
| | CaO19.6667 | SAP30_Sin3_bdg domain-containing protein. (168 aa) |
| | ZCF14 | Zcf14p. (528 aa) |
| | ZCF13 | Zcf13p. (1242 aa) |
| | CTA7 | Cta7p. (834 aa) |
| | RAD9 | Chromatin-binding protein. (1174 aa) |
| | ZCF22 | Zcf22p. (699 aa) |
| | LEU3 | Leucine-responsive transcriptional regulator. (984 aa) |
| | CaO19.3170 | DUF3835 domain-containing protein. (728 aa) |
| | FCR3 | Fcr3p. (399 aa) |
| | HAP5 | Hap5p. (348 aa) |
| | HMS1 | Hms1p. (685 aa) |
| | RPT5 | Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (430 aa) |
| | A0A1D8PMJ7 | Chromatin DNA-binding EKC/KEOPS complex subunit. (98 aa) |
| | HOS1 | Histone deacetylase. (436 aa) |
| | CGT1 | mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family. (449 aa) |
| | PHO4 | Phosphate-sensing transcription factor. (659 aa) |
| | HFL2 | Negative cofactor 2 transcription regulator complex subunit. (146 aa) |
| | UME7 | DNA-binding transcriptional regulator. (458 aa) |
| | ZCF25 | Zcf25p. (805 aa) |
| | HAP3 | Hap3p. (329 aa) |
| | RLM1 | Rlm1p. (601 aa) |
| | ZCF21 | Zcf21p. (629 aa) |
| | CaO19.5651 | Histone demethylase. (723 aa) |
| | TAF60 | Taf60p. (519 aa) |
| | CTA4 | Oleate-activated transcription factor. (1016 aa) |
| | ZCF35 | Zcf35p. (1102 aa) |
| | ZCF16 | Zcf16p. (1078 aa) |
| | MBP1 | Transcription factor. (852 aa) |
| | CaO19.239 | RSC chromatin remodeling complex ATPase subunit. (1302 aa) |
| | ZCF8 | Zcf8p. (915 aa) |
| | LYS144 | Lys144p. (860 aa) |
| | GCN4 | Amino acid starvation-responsive transcription factor. (323 aa) |
| | RPT6 | Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (401 aa) |
| | TOR1 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2482 aa) |
| | ZCF10 | Zcf10p. (921 aa) |
| | CaO19.6888 | Zn(2)-C6 fungal-type domain-containing protein. (442 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | INO4 | Ino4p. (130 aa) |
| | SNF2 | SWI/SNF catalytic subunit. (1690 aa) |
| | CTF1 | Ctf1p. (1144 aa) |
| | ZCF6 | Zcf6p. (369 aa) |
| | ZCF9 | Zcf9p. (834 aa) |
| | CaO19.4959 | Uncharacterized protein. (573 aa) |
| | RTG3 | Rtg3p. (520 aa) |
| | HAP43 | Hap43p. (634 aa) |
| | CaO19.4768 | Uncharacterized protein. (531 aa) |
| | LYS143 | Lys143p. (876 aa) |
| | LYS142 | Lys142p. (689 aa) |
| | SWI6 | Transcriptional regulator. (729 aa) |
| | CaO19.4437 | Chromatin-remodeling ATPase. (1017 aa) |
| | HAC1 | Transcription factor. (367 aa) |
| | ARO80 | Aro80p. (1065 aa) |
| | CDC73 | Cdc73p. (370 aa) |
| | SWI4 | SBF complex DNA-binding subunit. (1019 aa) |
| | HOT1 | GCR1_C domain-containing protein. (607 aa) |
| | NCB2 | Negative cofactor 2 transcription regulator complex subunit. (149 aa) |
| | PR26 | Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (411 aa) |
| | CDC68 | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa) |
| | GZF3 | Transcriptional regulator GZF3; Probable transcription factor involved in response to fluconazole, LiCl, and copper. (712 aa) |
| | RPT1 | Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (444 aa) |
| | ISW2 | ISWI chromatin-remodeling complex ATPase ISW2; Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens; Belongs to the SNF2/RAD54 helicase fa [...] (1056 aa) |
| | NUT2 | Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (170 aa) |
| | GAT1 | Transcriptional regulatory protein GAT1; Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model. (688 aa) |
| | AHR1 | Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state. (624 aa) |
| | MRR1 | Multidrug resistance regulator 1; Transcription factor that acts as the central regulator of the MDR1 efflux pump. Other target genes include those encoding oxidoreductases, whose up-regulation in fluconazole-resistant isolates may help to prevent cell damage resulting from the generation of toxic molecules in the presence of fluconazole and thereby contribute to drug resistance. (1108 aa) |
| | CRZ1 | Transcriptional regulator CRZ1; Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity. Binds to the calcineurin-dependent response element. Plays a role in azole tolerance. (731 aa) |
| | SSN8 | RNA polymerase II holoenzyme cyclin-like subunit; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By s [...] (434 aa) |
| | SKN7 | Transcription factor SKN7; Transcription factor that is part of a SLN1-YPD1-SKN7 two- component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes. (559 aa) |
| | GAL4 | Galactose-responsive transcription factor. (261 aa) |
| | MET4 | Met4p. (385 aa) |
| | BAS1 | Bas1p. (738 aa) |
| | KAE1 | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (372 aa) |
| | HAP31 | Hap31p. (105 aa) |
| | RON1 | NDT80 domain-containing protein. (490 aa) |
| | RPT4 | Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (428 aa) |
| | CCR4 | Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (787 aa) |
| | CAT8 | DNA-binding transcription factor. (1056 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa) |
| | FKH2 | Fork-head transcriptional regulator 2; Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence. (687 aa) |
| | JHD1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (478 aa) |
| | CaO19.3242 | Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (244 aa) |
| | STB5 | Stb5p. (640 aa) |
| | MBF1 | Multiprotein-bridging factor 1; Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. (151 aa) |
| | HDA1 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa) |
| | GIM5 | Gim5p. (158 aa) |
| | KIN28 | TFIIH complex serine/threonine-protein kinase subunit; Belongs to the protein kinase superfamily. (343 aa) |
| | PUT3 | Put3p. (978 aa) |
| | RCA1 | Rca1p. (283 aa) |
| | UGA32 | Uga32p. (583 aa) |
| | CDC5 | Serine/threonine-protein kinase. (653 aa) |
| | LYS14 | Lys14p. (592 aa) |
| | NDT80 | Transcription factor. (504 aa) |
| | SAS2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa) |
| | RPD31 | Histone deacetylase. (577 aa) |
| | SSN6 | Transcription regulator. (1080 aa) |
| | MED7 | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (304 aa) |
| | ZUO1 | Zuotin. (427 aa) |
| | MAC1 | Metal-binding activator 1; Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth. (431 aa) |
| | MCM1 | Transcription factor of morphogenesis MCM1; Transcription factor that is recruited by AHR1 to the promoters of genes involved in biofilm formation, which include several key adhesion genes. Plays an important role in cell adhesion, hyphal growth and virulence. Implicated in the regulation of opaque-phase- specific gene expression. (262 aa) |
| | BUR2 | Bur2p; Belongs to the cyclin family. (526 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (618 aa) |
| | SSN3 | Serine/threonine-protein kinase SSN3; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity). (608 aa) |
| | CaO19.1619 | Cyclin-dependent serine/threonine protein kinase. (586 aa) |
| | CAP1 | AP-1-like transcription factor CAP1; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Involved in the oxidative stress response in via multiple pathways, including the cellular antioxidant defense system, carbohydrate metabolism and energy metabolism, protein degradation, ATP-dependent RNA helicase, and resistance pathways. The ability of the major systemic fungal pathogen of humans to sense and respond to reactive oxygen species, such as H(2)O(2) ge [...] (499 aa) |
| | SFL2 | Transcription factor SFL2; Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature. Required for human oral epithelium colonization and damage. Promotes filamentous growth in EFG1- and FLO8-dependent manners. Antagonizes functions of SFL1. Belongs to the HSF family. (714 aa) |
| | SPT4 | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (112 aa) |
| | CUP2 | Cup2p. (591 aa) |
| | STP2 | Transcriptional regulator STP2; Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyph [...] (584 aa) |
| | TYE7 | Carbohydrate metabolism regulator TYE7; Key transcriptional regulator of carbohydrate metabolism. Binds the promoter sequences of the glycolytic genes at the CANNTG motif and activates their expression during growth on either fermentable or non-fermentable carbon sources as well as under hypoxic growth conditions. Complete glycolytic activation by GAL4 and TYE7 is required for full virulence. Involved in biofilm formation and negatively regulates hyphal formation under hypoxia. Controls also the expression of the copper transport protein CTR1. (269 aa) |
| | SPT5 | Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (956 aa) |
| | TOA2 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (130 aa) |
| | TFG1 | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (608 aa) |
| | SFP1 | Zinc-coordinating transcription factor. (445 aa) |
| | ZCF32 | Zcf32p. (716 aa) |
| | STP3 | Transcriptional regulator STP3; Transcription factor that activates genes required for degradation of extracellular protein and uptake of peptides such as the secreted aspartyl protease SAP2 or the oligopeptide transporter OPT1. Required for virulence. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. (436 aa) |
| | TEC1 | Transcription activator TEC1; Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tub [...] (743 aa) |
| | WOR1 | White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...] (785 aa) |
| | SFU1 | Suppressor of ferric uptake 1; Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice. (517 aa) |
| | HCM1 | Hcm1p. (579 aa) |
| | BCY1 | cAMP-dependent protein kinase regulatory subunit. (459 aa) |
| | RIM101 | pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid- expressed genes. Specifically recognizes and binds the consensus sequence 5'-CCAAGAA-3'. Required for the control of alkaline pH-induced filamentation (dimorphic switch) and virulence. (661 aa) |
| | CaO19.4394 | Uncharacterized protein. (569 aa) |
