STRINGSTRING
ERG7 ERG7 ERG24 ERG24 HOG1 HOG1 ERG1 ERG1 CaO19.5963 CaO19.5963 THI4 THI4 ERG5 ERG5 TRX1 TRX1 ERG13 ERG13 IFE2 IFE2 CYB5 CYB5 CaO19.3957 CaO19.3957 AFL1 AFL1 ARO9 ARO9 NCP1 NCP1 ERG8 ERG8 ERG251 ERG251 ERG4 ERG4 DFG10 DFG10 ERG9 ERG9 ERG20 ERG20 ERG10 ERG10 THI20 THI20 ARO8 ARO8 SRT1 SRT1 ERG12 ERG12 IFE1 IFE1 HMG1 HMG1 ERG2 ERG2 IPK1 IPK1 MCR1 MCR1 KCS1 KCS1 ARO10 ARO10 ERG3 ERG3 IPK2 IPK2 ERG26 ERG26 CaO19.6438 CaO19.6438 LCB4 LCB4 INO1 INO1 ERG11 ERG11 THI13 THI13 RHR2 RHR2 ERG27 ERG27 ERG6 ERG6 PHHB PHHB THI6 THI6 CaO19.4294 CaO19.4294 DPP3 DPP3 DES1 DES1 RER2 RER2 LCB2 LCB2 CaO19.4680 CaO19.4680 ERG25 ERG25
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ERG7Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. (728 aa)
ERG24Delta(14)-sterol reductase. (448 aa)
HOG1Mitogen-activated protein kinase HOG1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Regulates stress-induced production and accumulation of glycerol and D-arabitol. HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program. (377 aa)
ERG1Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. (496 aa)
CaO19.5963Ditrans,polycis-polyprenyl diphosphate synthase. (349 aa)
THI4Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (354 aa)
ERG5C-22 sterol desaturase; Belongs to the cytochrome P450 family. (517 aa)
TRX1Thioredoxin; Belongs to the thioredoxin family. (103 aa)
ERG133-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (451 aa)
IFE2Ife2p. (435 aa)
CYB5Cyb5p; Belongs to the cytochrome b5 family. (126 aa)
CaO19.3957GTP cyclohydrolase I. (272 aa)
AFL1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (735 aa)
ARO9Aromatic-amino-acid:2-oxoglutarate transaminase. (523 aa)
NCP1NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
ERG8Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (432 aa)
ERG251Erg251p; Belongs to the sterol desaturase family. (321 aa)
ERG4Delta(24(24(1)))-sterol reductase. (469 aa)
DFG10Putative polyprenol reductase. (282 aa)
ERG9Bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase. (448 aa)
ERG20Bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase; Belongs to the FPP/GGPP synthase family. (351 aa)
ERG10Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
THI20Trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase. (548 aa)
ARO8Bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase. (491 aa)
SRT1Alkyl transferase; Belongs to the UPP synthase family. (314 aa)
ERG12Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (431 aa)
IFE1Putative dehydrogenase. (394 aa)
HMG13-hydroxy-3-methylglutaryl coenzyme A reductase. (1073 aa)
ERG2C-8 sterol isomerase. (217 aa)
IPK1Inositol-pentakisphosphate 2-kinase; Has kinase activity and phosphorylates inositol-1,3,4,5,6- pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6- hexakisphosphate (InsP6), also known as phytate; Belongs to the IPK1 type 1 family. (361 aa)
MCR1NADH-cytochrome b5 reductase 2; May mediate the reduction of outer membrane cytochrome b5. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)
KCS1Kinase; Belongs to the inositol phosphokinase (IPK) family. (352 aa)
ARO10Phenylpyruvate decarboxylase. (629 aa)
ERG3C-5 sterol desaturase; Belongs to the sterol desaturase family. (386 aa)
IPK2Kinase; Belongs to the inositol phosphokinase (IPK) family. (350 aa)
ERG26Sterol-4-alpha-carboxylate 3-dehydrogenase (Decarboxylating). (350 aa)
CaO19.6438Serine C-palmitoyltransferase. (587 aa)
LCB4Sphinganine kinase. (530 aa)
INO1Inositol-3-phosphate synthase; Belongs to the myo-inositol 1-phosphate synthase family. (520 aa)
ERG11Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol. (528 aa)
THI134-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. Belongs to the NMT1/THI5 family. (339 aa)
RHR2Glycerol-1-phosphatase. (254 aa)
ERG273-keto-steroid reductase. (346 aa)
ERG6Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (376 aa)
PHHB4a-hydroxytetrahydrobiopterin dehydratase. (114 aa)
THI6Bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase. (514 aa)
CaO19.4294Oxidoreductase. (555 aa)
DPP3Bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase. (306 aa)
DES1Sphingolipid delta(4)-desaturase; Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides. Required for the formation of the monounsaturated sphingoid base (E)-sphing-4- enine during glucosylceramide (GluCer) biosynthesis. Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (370 aa)
RER2Alkyl transferase; Belongs to the UPP synthase family. (328 aa)
LCB2Serine C-palmitoyltransferase. (569 aa)
CaO19.4680DAGKc domain-containing protein. (381 aa)
ERG25Methylsterol monooxygenase; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (308 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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