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| | STE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (445 aa) |
| | ARP1 | Actin-related protein 1; Belongs to the actin family. (414 aa) |
| | FLO8 | Transcriptional regulator of filamentous growth FLO8; Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections. (792 aa) |
| | HAT2 | Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa) |
| | HRR25 | Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (433 aa) |
| | IPL1 | Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa) |
| | SPC2 | Signal peptidase complex subunit. (169 aa) |
| | MTLA1 | Mating-type-like protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating. Belongs to the MATA1 family. (210 aa) |
| | BCY1 | cAMP-dependent protein kinase regulatory subunit. (459 aa) |
| | URE2 | Protein URE2; Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity); Belongs to the GST superfamily. (344 aa) |
| | HOG1 | Mitogen-activated protein kinase HOG1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Regulates stress-induced production and accumulation of glycerol and D-arabitol. HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program. (377 aa) |
| | CAF20 | Cap-associated protein CAF20; Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity); Belongs to the CAF20 family. (176 aa) |
| | CPP1 | Dual specificity protein tyrosine phosphatase CCP1; Protein tyrosine phosphatase that acts as a repressor of the yeast-hyphal switch. Plays an important role in virulence. Negatively regulates CST20-HST7-CEK1-CPH1 filamentous growth pathway. Represses hyphal genes such as SAP4, SA5, SAP6, and HYR1, by acting through a CEK1-independent mechanism. (597 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1190 aa) |
| | CaO19.4824 | DSPc domain-containing protein. (272 aa) |
| | SFU1 | Suppressor of ferric uptake 1; Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice. (517 aa) |
| | TPK1 | Tpk1p; Belongs to the protein kinase superfamily. (405 aa) |
| | CaO19.5930 | FG-nucleoporin. (366 aa) |
| | ZCF32 | Zcf32p. (716 aa) |
| | SFP1 | Zinc-coordinating transcription factor. (445 aa) |
| | RFX2 | RFX-like DNA-binding protein RFX2; Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1; Belongs to the RFX family. (1111 aa) |
| | CaO19.4597 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (291 aa) |
| | CaO19.4615 | RXT2_N domain-containing protein. (318 aa) |
| | SPT5 | Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (956 aa) |
| | CDC55 | Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (519 aa) |
| | SLA1 | Actin cytoskeleton-regulatory complex protein SLA1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Required for assembly of the cortical actin cytoskeleton and for hyphal growth. Belongs to the SLA1 family. (1257 aa) |
| | CaO19.1476 | mRNA (N6-adenosine)-methyltransferase; Belongs to the MT-A70-like family. (543 aa) |
| | BNI1 | Formin BNI1; Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Required for the maintenance of polarized hyphal growth. BNI1-mediated actin cables are necessary for positioni [...] (1732 aa) |
| | KNS1 | Serine/threonine protein kinase. (666 aa) |
| | KAR9 | Kar9p. (758 aa) |
| | CaO19.3942 | ESCRT-II subunit protein. (196 aa) |
| | SFL2 | Transcription factor SFL2; Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature. Required for human oral epithelium colonization and damage. Promotes filamentous growth in EFG1- and FLO8-dependent manners. Antagonizes functions of SFL1. Belongs to the HSF family. (714 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (697 aa) |
| | PSY4 | Uncharacterized protein. (206 aa) |
| | IML1 | Vacuolar membrane-associated protein IML1. (1462 aa) |
| | VTS1 | Protein VTS1; RNA-binding protein involved in post-transcriptional regulation through transcript degradation. May be involved in vacuolar protein transport (By similarity). (679 aa) |
| | TPS2 | Trehalose-phosphatase. (888 aa) |
| | SSN3 | Serine/threonine-protein kinase SSN3; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity). (608 aa) |
| | SDS22 | Type 1 protein phosphatase-activating protein. (374 aa) |
| | CaO19.6461 | Cytochrome c oxidase assembly protein COX20, mitochondrial; Involved in the assembly of the cytochrome c oxidase complex. Belongs to the COX20 family. (171 aa) |
| | GIR2 | Gir2p. (259 aa) |
| | PDE1 | 3',5'-cyclic-nucleotide phosphodiesterase. (426 aa) |
| | ZUO1 | Zuotin. (427 aa) |
| | CaO19.2728 | Uncharacterized protein. (589 aa) |
| | MED7 | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (304 aa) |
| | CaO19.285 | mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (129 aa) |
| | CaO19.6722 | Uncharacterized protein. (709 aa) |
| | SSN6 | Transcription regulator. (1080 aa) |
| | RPD31 | Histone deacetylase. (577 aa) |
| | TPD3 | Protein phosphatase 2A structural subunit. (643 aa) |
| | NOT3 | General negative regulator of transcription subunit 3; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). Required for yeast cell adherence to silicone substrate, but nor required [...] (752 aa) |
| | CDH1 | Cdh1p. (597 aa) |
| | SAS2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa) |
| | HIR1 | Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa) |
| | TEL1 | Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2873 aa) |
| | CDC5 | Serine/threonine-protein kinase. (653 aa) |
| | RPL16A | Ribosomal 60S subunit protein L16A; Belongs to the universal ribosomal protein uL13 family. (200 aa) |
| | DHH1 | ATP-dependent RNA helicase DHH1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (549 aa) |
| | SUI2 | Translation initiation factor eIF2 subunit alpha. (300 aa) |
| | CaO19.6250 | Uncharacterized protein. (347 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa) |
| | MKC1 | Mitogen-activated protein kinase MKC1; Serine/threonine protein kinase component of the cell integrity pathway, a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. Participates in cell wall construction, azole resistance, and host interaction. Required for the signaling for invasive filamentous growth and biofilm formation, and plays a crucial role in virulence. (509 aa) |
| | BNR1 | Formin BNR1; May organize microtubules by mediating spindle positioning and movement in the budding process. Required for cytokinesis and the maintenance of polarized hyphal growth; Belongs to the formin homology family. BNI1 subfamily. (1485 aa) |
| | NPL4 | Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (598 aa) |
| | CHS7 | Chitin synthase export chaperone; Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum. (310 aa) |
| | CaO19.2544 | Aminoacyl-tRNA hydrolase. (198 aa) |
| | HDA1 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa) |
| | CaO19.3306 | HORMA domain-containing protein. (607 aa) |
| | CaO19.3348 | Mitochondrial 54S ribosomal protein YmL23. (176 aa) |
| | POP2 | CCR4-NOT core DEDD family RNase subunit. (492 aa) |
| | ORM1 | Sphingolipid homeostasis protein. (268 aa) |
| | CAP01 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (280 aa) |
| | FKH2 | Fork-head transcriptional regulator 2; Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence. (687 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa) |
| | PFY1 | Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa) |
| | CCR4 | Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (787 aa) |
| | SRV2 | Adenylyl cyclase-associated protein; Belongs to the CAP family. (545 aa) |
| | CaO19.5326 | Uncharacterized protein. (269 aa) |
| | SGS1 | ATP-dependent DNA helicase. (1189 aa) |
| | ASH1 | Transcriptional regulatory protein ASH1; Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis. (449 aa) |
| | FYV10 | Protein FYV10; Involved in the proteasome-dependent degradation of fructose- 1,6-bisphosphatase; Belongs to the FYV10 family. (572 aa) |
| | AHR1 | Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state. (624 aa) |
| | GAT1 | Transcriptional regulatory protein GAT1; Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model. (688 aa) |
| | PGA13 | GPI-anchored protein 13; Cell wall protein which contributes to cell wall synthesis and is important for acquiring normal surface properties. Required for virulence in a mouse infection model. (456 aa) |
| | NPR3 | Nitrogen permease regulator 3; Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity). (715 aa) |
| | DOT1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (1343 aa) |
| | CaO19.423 | Uncharacterized protein. (185 aa) |
| | RFG1 | Repressor of filamentous growth 1; Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5. (600 aa) |
| | GZF3 | Transcriptional regulator GZF3; Probable transcription factor involved in response to fluconazole, LiCl, and copper. (712 aa) |
| | MPH1 | ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1187 aa) |
| | MSH2 | Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa) |
| | NCB2 | Negative cofactor 2 transcription regulator complex subunit. (149 aa) |
| | CaO19.5833 | Polyubiquitin-binding protein. (363 aa) |
| | NRG1 | Transcriptional regulator NRG1; Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament- specific gene expression in r [...] (310 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | YPI1 | Type 1 phosphatases regulator YPI1; Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control; Belongs to the YPI1 family. (124 aa) |
| | YPI2 | Type 1 phosphatases regulator YPI2; Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control; Belongs to the YPI1 family. (147 aa) |
| | CaO19.3537 | Sulfiredoxin. (132 aa) |
| | FHL1 | Fork-head transcriptional regulator FHL1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1. (1152 aa) |
| | SUP35 | Translation termination factor GTPase eRF3. (721 aa) |
| | MSH3 | DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1037 aa) |
| | SET2 | Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (844 aa) |
| | IFF8 | Cell wall protein IFF7; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family. (714 aa) |
| | CaO19.4078 | Exosome non-catalytic core subunit. (337 aa) |
| | CSM3 | Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (316 aa) |
| | CDC48 | AAA family ATPase; Belongs to the AAA ATPase family. (826 aa) |
| | MAD2 | Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (413 aa) |
| | ATP25 | ATPase synthesis protein 25, mitochondrial; Probable mitochondrial mRNA stabilization factor. Belongs to the ATP25 family. (580 aa) |
| | SSU72 | RNA polymerase II subunit A C-terminal domain phosphatase. (226 aa) |
| | CaO19.1150 | GATA-type domain-containing protein. (472 aa) |
| | CaO19.1304 | Exosome non-catalytic core subunit. (304 aa) |
| | UBC8 | E2 ubiquitin-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (190 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (944 aa) |
| | SOL1 | Sol1p. (238 aa) |
| | BFA1 | Bfa1p. (428 aa) |
| | CaO19.6075 | CCR4-NOT core subunit. (182 aa) |
| | SIN3 | Transcriptional regulator. (1411 aa) |
| | CaO19.3304 | Exosome non-catalytic core subunit. (270 aa) |
| | CaO19.3333 | mRNA-binding protein. (431 aa) |
| | GAL10 | Bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase. (675 aa) |
| | PDE2 | Phosphodiesterase. (571 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa) |
| | PIL1 | Lipid-binding protein. (308 aa) |
| | CaO19.6259 | Exosome non-catalytic core subunit. (374 aa) |
| | NOT5 | CCR4-NOT core subunit. (662 aa) |
| | PTC1 | Type 2C protein phosphatase. (375 aa) |
| | HAP43 | Hap43p. (634 aa) |
| | CaO19.667 | Uncharacterized protein. (726 aa) |
| | GIN1 | Chromatin-modulating protein. (1234 aa) |
| | CDC6 | Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1214 aa) |
| | MPT5 | Mpt5p. (938 aa) |
| | CSK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. (374 aa) |
| | CaO19.7256 | RNA-binding protein. (77 aa) |
| | RAD23 | Rad23p. (416 aa) |
| | OPI1 | Transcriptional regulator. (432 aa) |
| | BUB2 | Bub2p. (314 aa) |
| | SSY1 | Ssy1p. (880 aa) |
| | CaO19.808 | Rpd3L histone deacetylase complex subunit. (610 aa) |
| | CaO19.4502 | DNA-binding ATPase. (1915 aa) |
| | RPB4 | DNA-directed RNA polymerase II subunit. (268 aa) |
| | CaO19.3547 | PUM-HD domain-containing protein. (667 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | CaO19.4110 | Uncharacterized protein. (1042 aa) |
| | CaO19.2228 | Uncharacterized protein. (406 aa) |
| | TOR1 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2482 aa) |
| | CaO19.1874 | Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa) |
| | MAF1 | Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (380 aa) |
| | CaO19.1434 | Protein kinase activating protein. (716 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1171 aa) |
| | GTR1 | Rag GTPase. (352 aa) |
| | RAP1 | DNA-binding transcription factor. (430 aa) |
| | KIP2 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (665 aa) |
| | GCN1 | Gcn1p. (2415 aa) |
| | HOS2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa) |
| | CaO19.5381 | PUM-HD domain-containing protein. (783 aa) |
| | ZCF8 | Zcf8p. (915 aa) |
| | PPH21 | Serine/threonine-protein phosphatase. (360 aa) |
| | CaO19.229 | Ubiquitin-protein ligase. (417 aa) |
| | CaO19.267 | Cytokin_check_N domain-containing protein. (1213 aa) |
| | DDC1 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (488 aa) |
| | NPR2 | Nitrogen permease regulating protein. (660 aa) |
| | RAD53 | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa) |
| | A0A1D8PK71 | HABP4_PAI-RBP1 domain-containing protein. (267 aa) |
| | CaO19.5954 | WD_REPEATS_REGION domain-containing protein. (510 aa) |
| | FUN31 | Serine/threonine protein kinase. (1323 aa) |
| | TCC1 | Tcc1p. (748 aa) |
| | NUP159 | FG-nucleoporin. (850 aa) |
| | CaO19.366 | DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (336 aa) |
| | BUB3 | Bub3p. (373 aa) |
| | CaO19.5651 | Histone demethylase. (723 aa) |
| | ZCF21 | Zcf21p. (629 aa) |
| | RGT1 | Rgt1p. (1027 aa) |
| | HFL2 | Negative cofactor 2 transcription regulator complex subunit. (146 aa) |
| | BUB1 | Protein kinase. (900 aa) |
| | RRP42 | Exosome non-catalytic core subunit. (307 aa) |
| | EFB1 | Translation elongation factor 1 subunit beta; Belongs to the EF-1-beta/EF-1-delta family. (213 aa) |
| | CaO19.3792 | Uncharacterized protein. (785 aa) |
| | CaO19.3806 | Glucose-induced degradation complex subunit. (499 aa) |
| | RPL30 | Ribosomal 60S subunit protein L30. (106 aa) |
| | PUF3 | mRNA-binding protein. (929 aa) |
| | CaO19.1792 | Anaphase promoting complex subunit. (785 aa) |
| | TSC2 | Tsc2p. (1490 aa) |
| | OFD1 | Oxidative DNA demethylase. (617 aa) |
| | CaO19.1939 | mRNA-binding phosphate metabolism regulator. (364 aa) |
| | LEU3 | Leucine-responsive transcriptional regulator. (984 aa) |
| | TIF5 | Translation initiation factor eIF5. (420 aa) |
| | SST2 | GTPase-activating protein. (675 aa) |
| | CaO19.4262 | PUM-HD domain-containing protein. (480 aa) |
| | RAD9 | Chromatin-binding protein. (1174 aa) |
| | MIG1 | Transcription factor. (570 aa) |
| | CaO19.6667 | SAP30_Sin3_bdg domain-containing protein. (168 aa) |
| | GLN3 | Nitrogen-responsive transcriptional regulator. (682 aa) |
| | CaO19.3949 | Bromo domain-containing protein. (1314 aa) |
| | DUN1 | Serine/threonine protein kinase. (530 aa) |
| | CaO19.1185 | Ubiquitin-conjugating protein. (369 aa) |
| | CaO19.3648 | ERCC4 domain-containing protein. (587 aa) |
| | CaO19.4193 | ADF-H domain-containing protein. (136 aa) |
| | CaO19.132 | Uncharacterized protein. (593 aa) |
| | RCN1 | Rcn1p. (210 aa) |
| | CDC20 | Ubiquitin-protein transferase activating protein. (634 aa) |
| | SWD3 | Swd3p. (383 aa) |
| | CaO19.5617 | PHD domain-containing protein. (479 aa) |
| | CaO19.5627 | Uncharacterized protein. (368 aa) |
| | CaO19.4557 | Spc7 domain-containing protein. (1083 aa) |
| | CDC39 | CCR4-NOT core subunit. (2016 aa) |
| | PMR1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (917 aa) |
| | RTF1 | Rtf1p. (568 aa) |
| | CaO19.7036 | Uncharacterized protein. (426 aa) |
| | RFC2 | Replication factor C subunit 2. (363 aa) |
| | CaO19.6901 | 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase. (302 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa) |
| | GCN2 | Serine/threonine-protein kinase. (1764 aa) |
| | CRN1 | Coronin; Belongs to the WD repeat coronin family. (633 aa) |
| | LSM4 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (130 aa) |
| | HHO1 | Histone. (180 aa) |
| | SLA2 | Sla2p. (1063 aa) |
| | CaO19.7198 | CCR4-NOT core subunit. (331 aa) |
| | CaO19.7527 | Uncharacterized protein. (726 aa) |
| | LSM6 | U4/U6-U5 snRNP complex subunit. (80 aa) |
| | LRG1 | Lrg1p. (1468 aa) |
| | CaO19.3273 | RWD domain-containing protein. (296 aa) |
| | SAS3 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (805 aa) |
| | CaO19.3722 | Uncharacterized protein. (849 aa) |
| | CaO19.4395 | WD_REPEATS_REGION domain-containing protein. (613 aa) |
| | CEK2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa) |
| | CaO19.1856 | Uncharacterized protein. (340 aa) |
| | SMX4 | U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa) |
| | CaO19.3890 | DNA-dependent ATPase. (1097 aa) |
| | CaO19.6393 | Uncharacterized protein. (417 aa) |
| | DCP2 | Decapping enzyme complex catalytic subunit. (907 aa) |
| | LSM1 | U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation. (167 aa) |
| | MPS1 | Serine/threonine/tyrosine protein kinase. (690 aa) |
| | CaO19.7329 | E2 ubiquitin-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa) |
| | CaO19.7664 | zf-LYAR domain-containing protein. (134 aa) |
| | RHO1 | GTP-binding protein RHO1. (198 aa) |
| | SIR2 | NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa) |
| | TUP1 | Transcriptional repressor TUP1; Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of the response to farnesol. Plays an important role in the regulation of white-opaque switching. (512 aa) |
| | CDC28 | Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa) |
| | SEC14 | SEC14 cytosolic factor; Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity). (301 aa) |
| | CGR1 | Cell growth-regulated gene 1 protein; Involved in the cell growth regulation. (340 aa) |
| | ASC1 | Guanine nucleotide-binding protein subunit beta-like protein; Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in the negative regulation of translation of a specific subset of proteins (By similarity). Plays a role in morphogenesis and pathogenesis. (317 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa) |
| | DBF2 | Cell cycle protein kinase DBF2; Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Required for proper nuclear segregation, mitotic spindle organization, actomyosin ring contraction, primary septum assembly, and normal hyphal morphogenesis. (710 aa) |
| | LSP1 | Lipid-binding protein. (317 aa) |
| | SIT4 | Serine/threonine-protein phosphatase SIT4; Serine/threonine protein phosphatase which is involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1 (By similarity). Plays a role during hyphal growth through the regulation of cell wall biogenesis, osmosensing and protein translation. Involved in virulence in a mouse systemic infection model. (314 aa) |
| | ESS1 | Peptidyl-prolyl cis-trans isomerase. (177 aa) |
| | MEC1 | Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2325 aa) |
| | DBP2 | ATP-dependent RNA helicase DBP2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (562 aa) |
| | VPS22 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (261 aa) |
| | GLC7 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | MUS81 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa) |
| | CDC14 | Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa) |
| | YBL053 | Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1263 aa) |
| | EFH1 | Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. (720 aa) |
| | MEC3 | Checkpoint protein; Belongs to the HUS1 family. (319 aa) |
| | MAD1 | Spindle assembly checkpoint component MAD1; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. (696 aa) |
| | HMO1 | Transcriptional regulator HMO1; Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth. (223 aa) |
| | GCN5 | Histone acetyltransferase. (449 aa) |
| | RTS1 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (850 aa) |
| | CaO19.399 | Non-specific serine/threonine protein kinase. (712 aa) |
| | UPC2 | Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping. (712 aa) |
| | MFALPHA | Mating pheromone alpha. (143 aa) |
