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| | TUB2 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa) |
| | CaO19.3295 | Uncharacterized protein. (474 aa) |
| | ARP8 | Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (1066 aa) |
| | ESP1 | Separase. (1598 aa) |
| | CaO19.2926 | Uncharacterized protein. (830 aa) |
| | CaO19.2964 | Uncharacterized protein. (795 aa) |
| | CaO19.3019 | SsDNA-dependent ATPase. (678 aa) |
| | CaO19.3035 | Chromatin-remodeling ATPase. (1410 aa) |
| | CaO19.3062 | Uncharacterized protein. (1179 aa) |
| | CaO19.6843 | SHNi-TPR domain-containing protein. (373 aa) |
| | CHL4 | Chl4p. (465 aa) |
| | REC8 | Rad21_Rec8_N domain-containing protein. (635 aa) |
| | CaO19.427 | DNA-binding protein. (1665 aa) |
| | CaO19.2485 | Uncharacterized protein. (1426 aa) |
| | CaO19.2476 | Uncharacterized protein. (1684 aa) |
| | CaO19.4437 | Chromatin-remodeling ATPase. (1017 aa) |
| | CaO19.5053 | Uncharacterized protein. (260 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (867 aa) |
| | CaO19.5093 | Uncharacterized protein. (352 aa) |
| | CaO19.4801 | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (465 aa) |
| | CaO19.1834 | Uncharacterized protein. (910 aa) |
| | CAS1 | ATP-dependent DNA helicase. (811 aa) |
| | DLH1 | Recombinase; Belongs to the RecA family. (324 aa) |
| | CDC54 | DNA helicase; Belongs to the MCM family. (912 aa) |
| | CaO19.7213 | ATP-dependent 3'-5' DNA helicase. (1123 aa) |
| | IRR1 | Irr1p. (1089 aa) |
| | CaO19.7269 | Polyamine acetyltransferase. (220 aa) |
| | DPB4 | DNA polymerase epsilon noncatalytic subunit. (261 aa) |
| | RFC5 | Replication factor C subunit 5. (362 aa) |
| | CaO19.2041 | Uncharacterized protein. (636 aa) |
| | SNF2 | SWI/SNF catalytic subunit. (1690 aa) |
| | RAD32 | DNA-directed DNA polymerase eta. (640 aa) |
| | TAF14 | TATA-binding protein-associated factor. (263 aa) |
| | CaO19.4502 | DNA-binding ATPase. (1915 aa) |
| | CaO19.187 | Uncharacterized protein. (816 aa) |
| | CaO19.3552 | Uncharacterized protein. (1032 aa) |
| | CaO19.5212 | SUMO ligase. (366 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | PDS5 | Pds5p. (1303 aa) |
| | YCS4 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1172 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1171 aa) |
| | GTR1 | Rag GTPase. (352 aa) |
| | STN1 | Stn1p. (587 aa) |
| | RPT6 | Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (401 aa) |
| | CaO19.3601 | AAA domain-containing protein. (547 aa) |
| | CaO19.3604 | PAPA-1 domain-containing protein. (382 aa) |
| | CDC47 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa) |
| | CaO19.1363 | SWIRM domain-containing protein. (392 aa) |
| | RAP1 | DNA-binding transcription factor. (430 aa) |
| | PHO23 | Chromatin modification-related protein. (481 aa) |
| | HOS2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa) |
| | PPH21 | Serine/threonine-protein phosphatase. (360 aa) |
| | RAD50 | MRX complex DNA-binding subunit. (1332 aa) |
| | YCG1 | Condensin subunit. (1259 aa) |
| | CaO19.239 | RSC chromatin remodeling complex ATPase subunit. (1302 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1237 aa) |
| | CaO19.267 | Cytokin_check_N domain-containing protein. (1213 aa) |
| | HRT1 | SCF ubiquitin ligase complex subunit. (123 aa) |
| | SNF5 | Snf5p. (696 aa) |
| | A0A1D8PK71 | HABP4_PAI-RBP1 domain-containing protein. (267 aa) |
| | CaO19.5954 | WD_REPEATS_REGION domain-containing protein. (510 aa) |
| | KIP3 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa) |
| | CaO19.7433 | FG-nucleoporin. (1096 aa) |
| | TAF60 | Taf60p. (519 aa) |
| | SUB2 | ATP-dependent RNA helicase. (433 aa) |
| | CaO19.5651 | Histone demethylase. (723 aa) |
| | CaO19.5675 | Translocase. (1102 aa) |
| | CaO19.4677 | HIT-type domain-containing protein. (236 aa) |
| | CaO19.2743 | Uncharacterized protein. (606 aa) |
| | CaO19.2739 | Uncharacterized protein. (572 aa) |
| | CaO19.2730 | Uncharacterized protein. (606 aa) |
| | CaO19.2713 | MutS family protein. (802 aa) |
| | BUB1 | Protein kinase. (900 aa) |
| | NUP84 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (844 aa) |
| | CDL1 | Cdl1p. (673 aa) |
| | CaO19.1792 | Anaphase promoting complex subunit. (785 aa) |
| | BRN1 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (744 aa) |
| | TUB4 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (498 aa) |
| | HOS1 | Histone deacetylase. (436 aa) |
| | CaO19.2922 | TBPIP domain-containing protein. (205 aa) |
| | A0A1D8PMJ7 | Chromatin DNA-binding EKC/KEOPS complex subunit. (98 aa) |
| | CaO19.2889 | YL1_C domain-containing protein. (137 aa) |
| | TOP2 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1461 aa) |
| | CaO19.3080 | Sister chromatid cohesion protein. (1046 aa) |
| | CaO19.3169 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (352 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa) |
| | CaO19.4312 | SAGA complex subunit. (770 aa) |
| | CaO19.4301 | GATA-type domain-containing protein. (814 aa) |
| | CAC2 | Cac2p. (460 aa) |
| | CaO19.1111 | Chromatin modification protein. (231 aa) |
| | CaO19.3949 | Bromo domain-containing protein. (1314 aa) |
| | CaO19.3945 | PCI domain-containing protein. (476 aa) |
| | CaO19.3980 | Putative RNA helicase. (1929 aa) |
| | EST1 | Est1p. (612 aa) |
| | DNA2 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (780 aa) |
| | CaO19.3399 | YL1_C domain-containing protein. (764 aa) |
| | CTF5 | Ctf5p. (366 aa) |
| | CaO19.3473 | Deubiquitination module subunit. (549 aa) |
| | CaO19.5534 | Uncharacterized protein. (350 aa) |
| | MIF2 | Mif2p. (520 aa) |
| | CaO19.4557 | Spc7 domain-containing protein. (1083 aa) |
| | GLE2 | RNA export factor. (383 aa) |
| | RAD3 | TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit. (765 aa) |
| | CaO19.7101 | Telomere_reg-2 domain-containing protein. (788 aa) |
| | DCC1 | Dcc1p. (339 aa) |
| | CaO19.7088 | Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (382 aa) |
| | RFC2 | Replication factor C subunit 2. (363 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa) |
| | HHO1 | Histone. (180 aa) |
| | UME1 | Ume1p. (485 aa) |
| | RRM3 | ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (618 aa) |
| | SAS3 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (805 aa) |
| | SHP1 | Protein phosphatase regulator. (371 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | RPD3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa) |
| | CaO19.2857 | TFIIH/NER complex ATPase/helicase subunit. (843 aa) |
| | YKU80 | ATP-dependent DNA helicase. (609 aa) |
| | SMC1 | Structural maintenance of chromosomes protein. (1240 aa) |
| | NAT5 | Peptide alpha-N-acetyltransferase subunit. (175 aa) |
| | YDJ1 | Type I HSP40 co-chaperone. (393 aa) |
| | CaO19.6625 | Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (275 aa) |
| | KIP1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (911 aa) |
| | CaO19.702 | C2H2-type domain-containing protein. (1105 aa) |
| | CaO19.1841 | Uncharacterized protein. (374 aa) |
| | CaO19.3890 | DNA-dependent ATPase. (1097 aa) |
| | CaO19.607 | DNA-dependent ATPase. (1055 aa) |
| | RPN7 | Proteasome regulatory particle lid subunit. (400 aa) |
| | CaO19.7594 | Uncharacterized protein. (213 aa) |
| | MCD1 | Kleisin alpha. (564 aa) |
| | RFC4 | Replication factor C subunit 4. (323 aa) |
| | CSM1 | Csm1 domain-containing protein. (225 aa) |
| | HMI1 | ATP-dependent 3'-5' DNA helicase. (637 aa) |
| | SIR2 | NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa) |
| | RBP1 | FK506-binding protein 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (124 aa) |
| | CDC28 | Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa) |
| | HSP90 | Heat shock protein 90 homolog; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family. (707 aa) |
| | HTB1 | Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa) |
| | RAD14 | DNA repair protein RAD14; Involved in DNA excision repair; Belongs to the XPA family. (396 aa) |
| | SPT6 | Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1401 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa) |
| | INO80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1387 aa) |
| | YAF9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (254 aa) |
| | CaO19.5041 | Uncharacterized protein. (357 aa) |
| | CaO19.190 | Uncharacterized protein. (324 aa) |
| | CSE4 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (211 aa) |
| | MEC1 | Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2325 aa) |
| | PSF2 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa) |
| | ASF1 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (247 aa) |
| | GLC7 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | RAD52 | Recombinase. (564 aa) |
| | MUS81 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa) |
| | CDC14 | Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa) |
| | GSP1 | GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (214 aa) |
| | CDC46 | DNA helicase; Belongs to the MCM family. (728 aa) |
| | MEC3 | Checkpoint protein; Belongs to the HUS1 family. (319 aa) |
| | MAD1 | Spindle assembly checkpoint component MAD1; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. (696 aa) |
| | HMO1 | Transcriptional regulator HMO1; Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth. (223 aa) |
| | SWD2 | WD-repeat containing protein. (364 aa) |
| | GCN5 | Histone acetyltransferase. (449 aa) |
| | RTS1 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (850 aa) |
| | EAF6 | Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (211 aa) |
| | HAT2 | Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa) |
| | CHZ1 | Histone H2A.Z-specific chaperone CHZ1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin. (167 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa) |
| | HRR25 | Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (433 aa) |
| | IPL1 | Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa) |
| | SWR1 | Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (413 aa) |
| | HHF1 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa) |
| | HTB2 | Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (130 aa) |
| | MAD2 | Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa) |
| | CaO19.3673 | Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (168 aa) |
| | SMT3 | SUMO family protein. (102 aa) |
| | CDC48 | AAA family ATPase; Belongs to the AAA ATPase family. (826 aa) |
| | ADA2 | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa) |
| | CTF8 | Ctf8p. (162 aa) |
| | RSP5 | E3 ubiquitin-protein ligase. (832 aa) |
| | MTW1 | MIND complex subunit. (314 aa) |
| | CaO19.3581 | WD_REPEATS_REGION domain-containing protein. (435 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | NCB2 | Negative cofactor 2 transcription regulator complex subunit. (149 aa) |
| | PR26 | Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (411 aa) |
| | CaO19.3130 | GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (273 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa) |
| | MSH2 | Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa) |
| | VID21 | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (686 aa) |
| | MPH1 | ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1187 aa) |
| | CDC68 | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa) |
| | SET5 | Potential protein lysine methyltransferase SET5; Putative protein lysine methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily. (473 aa) |
| | NUF2 | Probable kinetochore protein NUF2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (485 aa) |
| | NDC80 | Probable kinetochore protein NDC80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (788 aa) |
| | DOT1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (1343 aa) |
| | ISW2 | ISWI chromatin-remodeling complex ATPase ISW2; Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens; Belongs to the SNF2/RAD54 helicase fa [...] (1056 aa) |
| | CDC23 | Anaphase promoting complex subunit. (582 aa) |
| | CaO19.5276 | PCI domain-containing protein. (415 aa) |
| | SGF11 | SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (120 aa) |
| | BDF1 | Bromodomain-containing factor 1; Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA- damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity). (732 aa) |
| | BRE1 | E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (681 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1368 aa) |
| | CaO19.955 | Uncharacterized protein. (325 aa) |
| | NAM7 | ATP-dependent RNA helicase. (1019 aa) |
| | CGI121 | EKC/KEOPS complex subunit CGI121; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transc [...] (203 aa) |
| | RDH54 | DNA-dependent ATPase. (796 aa) |
| | PSO2 | Pso2p. (537 aa) |
| | ASH1 | Transcriptional regulatory protein ASH1; Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis. (449 aa) |
| | SGS1 | ATP-dependent DNA helicase. (1189 aa) |
| | KAE1 | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (372 aa) |
| | CaO19.504 | Uncharacterized protein; Belongs to the actin family. (776 aa) |
| | EAF7 | Chromatin modification-related protein EAF7; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (445 aa) |
| | EST3 | Telomere replication protein EST3; Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity). (210 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa) |
| | JHD1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (478 aa) |
| | TEN1 | Ten1p. (126 aa) |
| | CaO19.3242 | Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (244 aa) |
| | SWC5 | SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (338 aa) |
| | CaO19.3349 | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1234 aa) |
| | CaO19.3306 | HORMA domain-containing protein. (607 aa) |
| | HDA1 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa) |
| | HST2 | NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily. (331 aa) |
| | NAP1 | Nucleosome assembly protein 1; Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis. (435 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa) |
| | PUT3 | Put3p. (978 aa) |
| | CaO19.6199 | ATP-dependent 5'-3' DNA helicase. (719 aa) |
| | CDC13 | Cdc13p. (447 aa) |
| | CDC5 | Serine/threonine-protein kinase. (653 aa) |
| | SET1 | Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1040 aa) |
| | ASA1 | ASTRA-associated protein 1; Component of the ASTRA complex involved in chromatin remodeling. (377 aa) |
| | TEL1 | Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2873 aa) |
| | ARP4 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (468 aa) |
| | HIR1 | Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa) |
| | RAD5 | DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1084 aa) |
| | RFA1 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa) |
| | SAS2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa) |
| | CHL1 | ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (842 aa) |
| | TPD3 | Protein phosphatase 2A structural subunit. (643 aa) |
| | RPD31 | Histone deacetylase. (577 aa) |
| | SSN6 | Transcription regulator. (1080 aa) |
| | SUS1 | Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (119 aa) |
| | CaO19.6726 | Uncharacterized protein. (332 aa) |
| | CaO19.6722 | Uncharacterized protein. (709 aa) |
| | HIR3 | Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Belongs to the HIR3 family. (1591 aa) |
| | HTZ1 | Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa) |
| | HIR2 | Protein HIR2; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa) |
| | CaO19.6537 | MIND complex subunit. (230 aa) |
| | CDC34 | SCF E2 ubiquitin-protein ligase catalytic subunit; Belongs to the ubiquitin-conjugating enzyme family. (244 aa) |
| | YNG2 | Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (298 aa) |
| | TBF1 | Transcription factor TBF1; Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci. Recruits FHL1 and IFH1 to promoters. (886 aa) |
| | NGG1 | Histone acetyltransferase. (627 aa) |
| | CaO19.2985 | Uncharacterized protein. (172 aa) |
| | RAD16 | DNA repair protein. (852 aa) |
| | CaO19.1720 | Putative ATPase. (864 aa) |
| | CDC53 | Cullin; Belongs to the cullin family. (752 aa) |
| | CaO19.1668 | Uncharacterized protein. (623 aa) |
| | CaO19.1667 | Uncharacterized protein. (1250 aa) |
| | SPT4 | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (112 aa) |
| | HPC2 | Hpc2p. (552 aa) |
| | RAD54 | DNA-dependent ATPase. (848 aa) |
| | POB3 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (538 aa) |
| | CaO19.4617 | Peptide alpha-N-acetyltransferase. (178 aa) |
| | CaO19.4615 | RXT2_N domain-containing protein. (318 aa) |
| | CaO19.5970 | DNA helicase. (862 aa) |
| | CaO19.5934 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa) |
| | ARP6 | Actin-like protein ARP6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa) |
| | DAM1 | DASH complex subunit DAM1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (277 aa) |
