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| | HMI1 | ATP-dependent 3'-5' DNA helicase. (637 aa) |
| | LIG4 | DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae. (928 aa) |
| | INO80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1387 aa) |
| | MUS81 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa) |
| | CaO19.2798 | Double-stranded DNA-dependent ATPase. (655 aa) |
| | CaO19.2797 | Uncharacterized protein. (623 aa) |
| | CaO19.4412 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1113 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa) |
| | MLH1 | Mismatch repair ATPase. (717 aa) |
| | SWR1 | Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa) |
| | MSH3 | DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1037 aa) |
| | CaO19.1406 | Uncharacterized protein. (256 aa) |
| | DEM1 | Exonuclease V, mitochondrial; Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity). (628 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa) |
| | MSH2 | Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa) |
| | MPH1 | ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1187 aa) |
| | MHR1 | Mitochondrial homologous recombination protein 1; Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (By similarity); Belongs to the mitochondrion-specific ribosomal protein mL67 family. (239 aa) |
| | ISW2 | ISWI chromatin-remodeling complex ATPase ISW2; Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens; Belongs to the SNF2/RAD54 helicase fa [...] (1056 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (286 aa) |
| | CaO19.967 | Endonuclease. (320 aa) |
| | RDH54 | DNA-dependent ATPase. (796 aa) |
| | PSO2 | Pso2p. (537 aa) |
| | SGS1 | ATP-dependent DNA helicase. (1189 aa) |
| | RAD27 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (372 aa) |
| | CCE1 | Cruciform cutting endonuclease. (332 aa) |
| | CaO19.6199 | ATP-dependent 5'-3' DNA helicase. (719 aa) |
| | RAD5 | DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1084 aa) |
| | CHL1 | ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (842 aa) |
| | CaO19.6807 | Integrase catalytic domain-containing protein. (609 aa) |
| | CaO19.2728 | Uncharacterized protein. (589 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (776 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa) |
| | RAD16 | DNA repair protein. (852 aa) |
| | CaO19.1720 | Putative ATPase. (864 aa) |
| | CaO19.1667 | Uncharacterized protein. (1250 aa) |
| | FGR23 | Filamentous growth regulator 23; Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth. (1114 aa) |
| | HYS2 | DNA-directed DNA polymerase delta subunit. (474 aa) |
| | RAD54 | DNA-dependent ATPase. (848 aa) |
| | CaO19.4988 | SsDNA endodeoxyribonuclease. (505 aa) |
| | RAT1 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (968 aa) |
| | CaO19.5970 | DNA helicase. (862 aa) |
| | SEN1 | Putative DNA/RNA helicase. (2018 aa) |
| | CaO19.5934 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa) |
| | POL93 | Pol93p. (653 aa) |
| | TRM2 | Trm2p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (551 aa) |
| | CaO19.2926 | Uncharacterized protein. (830 aa) |
| | CaO19.3019 | SsDNA-dependent ATPase. (678 aa) |
| | CaO19.3035 | Chromatin-remodeling ATPase. (1410 aa) |
| | POL32 | DNA polymerase delta subunit. (403 aa) |
| | CaO19.4437 | Chromatin-remodeling ATPase. (1017 aa) |
| | NTG1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (320 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (867 aa) |
| | APN2 | DNA-(Apurinic or apyrimidinic site) lyase. (451 aa) |
| | CAS1 | ATP-dependent DNA helicase. (811 aa) |
| | DLH1 | Recombinase; Belongs to the RecA family. (324 aa) |
| | CDC54 | DNA helicase; Belongs to the MCM family. (912 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1214 aa) |
| | CaO19.7213 | ATP-dependent 3'-5' DNA helicase. (1123 aa) |
| | MLH3 | Mismatch repair protein. (636 aa) |
| | RAD7 | UV-damaged DNA-binding protein. (652 aa) |
| | SNF2 | SWI/SNF catalytic subunit. (1690 aa) |
| | RAD32 | DNA-directed DNA polymerase eta. (640 aa) |
| | CaO19.810 | Uncharacterized protein. (1247 aa) |
| | CaO19.4502 | DNA-binding ATPase. (1915 aa) |
| | RFC1 | Replication factor C subunit 1. (888 aa) |
| | ORF298 | Uncharacterized protein. (1208 aa) |
| | RAD57 | Putative DNA-dependent ATPase. (511 aa) |
| | CaO19.3639 | ENDO3c domain-containing protein. (354 aa) |
| | CaO19.3601 | AAA domain-containing protein. (547 aa) |
| | SPO11 | Spo11p. (309 aa) |
| | CDC47 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa) |
| | PMS1 | ATP-binding mismatch repair protein. (910 aa) |
| | RAD1 | SsDNA endodeoxyribonuclease. (970 aa) |
| | CaO19.5469 | Uncharacterized protein. (1064 aa) |
| | CaO19.6155 | DNA ligase. (770 aa) |
| | RAD50 | MRX complex DNA-binding subunit. (1332 aa) |
| | CaO19.239 | RSC chromatin remodeling complex ATPase subunit. (1302 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1237 aa) |
| | POL1 | DNA polymerase. (1470 aa) |
| | REV3 | DNA polymerase. (1630 aa) |
| | UNG1 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (355 aa) |
| | CaO19.7442 | UDG domain-containing protein. (298 aa) |
| | APN1 | DNA-(Apurinic or apyrimidinic site) lyase. (364 aa) |
| | CaO19.5675 | Translocase. (1102 aa) |
| | CaO19.4163 | Uncharacterized protein. (1072 aa) |
| | CaO19.2713 | MutS family protein. (802 aa) |
| | CaO19.2664 | XPGI domain-containing protein. (898 aa) |
| | RAD2 | SsDNA endodeoxyribonuclease. (990 aa) |
| | TOP2 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1461 aa) |
| | EXO1 | Rad2 family nuclease. (699 aa) |
| | CaO19.3949 | Bromo domain-containing protein. (1314 aa) |
| | DNA2 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (780 aa) |
| | CaO19.3431 | DNA-directed DNA polymerase gamma. (1229 aa) |
| | FPG1 | Fpg1p. (372 aa) |
| | RAD3 | TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit. (765 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (682 aa) |
| | POL3 | DNA polymerase. (1038 aa) |
| | OGG1 | 8-oxoguanine glycosylase. (353 aa) |
| | RRM3 | ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (618 aa) |
| | CaO19.2541 | 3'-5'-exodeoxyribonuclease. (414 aa) |
| | CaO19.2579 | MutS family protein. (803 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | CaO19.2857 | TFIIH/NER complex ATPase/helicase subunit. (843 aa) |
| | CaO19.2376 | zf-C2HE domain-containing protein. (259 aa) |
| | YKU80 | ATP-dependent DNA helicase. (609 aa) |
| | CaO19.4383 | DNA 5'-adenosine monophosphate hydrolase. (259 aa) |
| | CaO19.496 | Mismatch repair ATPase. (923 aa) |
| | RPS3 | Ribosomal 40S subunit protein S3. (251 aa) |
| | CaO19.652 | Crossover junction endodeoxyribonuclease. (684 aa) |
| | CaO19.702 | C2H2-type domain-containing protein. (1105 aa) |
| | POL2 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2211 aa) |
| | CaO19.3890 | DNA-dependent ATPase. (1097 aa) |
| | CaO19.607 | DNA-dependent ATPase. (1055 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation. (179 aa) |
