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| | MRR2 | Multidrug resistance regulator 2; Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence. (710 aa) |
| | FGR27 | Filamentous growth regulator 27; Transcription factor involved in yeast cell adherence to silicone substrate, filamentous growth, and biofilm formation. (787 aa) |
| | EFH1 | Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. (720 aa) |
| | SOH1 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (146 aa) |
| | UPC2 | Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping. (712 aa) |
| | FLO8 | Transcriptional regulator of filamentous growth FLO8; Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections. (792 aa) |
| | CPH2 | Transcription factor CPH2; Transcription factor that positively controls filamentous growth, virulence, and invasiveness. Binds directly to the two SRE-1- like elements upstream of TEC1 and thus regulates positively expression of this important hyphal growth regulator. Functions independently of known signaling cascades involving EFG1. Regulates also gene expression during intestinal colonization but is not involved in host cell adhesion. (853 aa) |
| | ACE2 | Cell wall transcription factor ACE2; Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection. (783 aa) |
| | MNL1 | Transcriptional regulator MNL1; Transcription factor that activates stress response genes via SLE (STRE-like) elements. Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress. Activates a subset of the genes that are repressed by NRG1. (905 aa) |
| | MED11 | Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (168 aa) |
| | CaO19.211 | HTH araC/xylS-type domain-containing protein. (180 aa) |
| | STB3 | Stb3p. (503 aa) |
| | CRZ2 | Transcriptional regulator CRZ2; Transcription factor that regulates pH-induced filamentation with RIM101. Required for yeast cell adherence to silicone substrate and biofilm formation. (517 aa) |
| | CaO19.6923 | TAFII28 domain-containing protein. (343 aa) |
| | CaO19.6874 | Uncharacterized protein. (607 aa) |
| | MED8 | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (239 aa) |
| | ZCF3 | Zcf3p. (195 aa) |
| | CaO19.1150 | GATA-type domain-containing protein. (472 aa) |
| | BCR1 | Biofilm and cell wall regulator 1; Transcription factor which acts as a master regulator of biofilm formation. Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis. Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 AND HYR1. Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation. (740 aa) |
| | CaO19.1897 | GCR1_C domain-containing protein. (344 aa) |
| | MED4 | Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (323 aa) |
| | CaO19.5666 | Chromatin-binding transcription coactivator. (146 aa) |
| | SEF1 | Transcriptional regulatory protein SEF1; Transcription factor which plays an essential role in virulence by activating the transcription of iron uptake genes such as FRE7 in iron-poor environments such as the host bloodstream and internal organs. Promotes commensalism in a mouse model of gastrointestinal infection. (917 aa) |
| | RFX1 | Transcriptional regulator RFX1; Transcription factor involved in DNA damage responses, morphogenesis, and virulence. (851 aa) |
| | RPN4 | Transcriptional regulator RPN4; Transcriptional activator of a number of genes encoding proteasomal subunits. Binds to the DNA sequence 5'-GAAGGCAAAA-3', enriched in regions upstream of proteasome genes. (536 aa) |
| | WAR1 | Transcriptional regulator WAR1; Transcription factor required for yeast cell adherence to silicone substrate. Plays a role in resistance to weak organic acids such as acetate and sorbate. Binds in vitro to a nitric oxide- responsive element (NORE) but seems not to be involved in response to nitrosative stress. (947 aa) |
| | SKO1 | Transcriptional regulator SKO1; Transcription repressor involved in cell wall damage response. Regulates 79 caspofungin-responsive genes, including several cell wall biogenesis genes such as CRH11, MNN2, and SKN1. Controls also the expression of pathogenesis and hyphal related genes and represses the yeast-to-hypha transition. Mediates the response to oxidative stress. (578 aa) |
| | ZCF23 | Glucose starvation modulator protein 1; Transcription factor which regulates nonfermentable carbon utilization; Belongs to the ERT1/acuK family. (566 aa) |
| | EFG1 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] (550 aa) |
| | MFG1 | Morphogenetic regulator of filamentous growth protein 1; Transcriptional regulator with a general role in all morphogenetically distinct forms of filamentous growth, namely invasive growth and biofilm formation. May control FLO11 gene expression as part of a promoter-bound complex with FLO8 and MSS1. Important for virulence; Belongs to the MFG1 family. (758 aa) |
| | AFT2 | Iron-regulated transcriptional activator AFT2; Transcription factor involved in iron metabolism, oxidative stress, surface adhesion, hyphal development and virulence. Functions as a negative regulator of MRS4 expression through the CACCC AFT-type sequence in a gene dose-dependent fashion. Acts as a repressor in flocculation, plastic adhesion, and surface hydrophobicity. (798 aa) |
| | FHL1 | Fork-head transcriptional regulator FHL1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1. (1152 aa) |
| | NRG1 | Transcriptional regulator NRG1; Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament- specific gene expression in r [...] (310 aa) |
| | CaO19.5841 | Uncharacterized protein. (252 aa) |
| | NCB2 | Negative cofactor 2 transcription regulator complex subunit. (149 aa) |
| | CaO19.3136 | Imp2'p. (458 aa) |
| | CZF1 | Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...] (385 aa) |
| | CBF1 | Transcriptional regulator CBF1; Transcription factor that binds ribosomal protein gene promoters and rDNA locus with TBF1. Necessary for the expression of genes involved in assimilation of inorganic sulfate. Also required for the expression of respiratory genes and glycolytic genes. Does not bind to centromeres and is not necessary for efficient chromosome segregationas as does S.cerevisiae CBF1. (251 aa) |
| | GZF3 | Transcriptional regulator GZF3; Probable transcription factor involved in response to fluconazole, LiCl, and copper. (712 aa) |
| | RFG1 | Repressor of filamentous growth 1; Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5. (600 aa) |
| | SFL1 | Transcription factor SFL1; Transcription factor that plays a role of repressor of filamentous growth and flocculation. Antagonizes functions of SFL2 and FLO8. Plays a role in the hyphal repression induced by secreted factors like dodecanol by competitors such as Pseudomonas aeruginosa and Burkholderia cenocepacia. (805 aa) |
| | SPT20 | Transcription factor SPT20; Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosom [...] (751 aa) |
| | MED6 | Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (263 aa) |
| | NUT2 | Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (170 aa) |
| | ZCF30 | Zcf30p. (799 aa) |
| | GAT1 | Transcriptional regulatory protein GAT1; Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model. (688 aa) |
| | AHR1 | Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state. (624 aa) |
| | MRR1 | Multidrug resistance regulator 1; Transcription factor that acts as the central regulator of the MDR1 efflux pump. Other target genes include those encoding oxidoreductases, whose up-regulation in fluconazole-resistant isolates may help to prevent cell damage resulting from the generation of toxic molecules in the presence of fluconazole and thereby contribute to drug resistance. (1108 aa) |
| | SGF11 | SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (120 aa) |
| | CRZ1 | Transcriptional regulator CRZ1; Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity. Binds to the calcineurin-dependent response element. Plays a role in azole tolerance. (731 aa) |
| | TRY5 | Transcriptional regulator of yeast form adherence 5; Transcription factor required for yeast cell adherence to silicone substrate. (988 aa) |
| | SKN7 | Transcription factor SKN7; Transcription factor that is part of a SLN1-YPD1-SKN7 two- component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes. (559 aa) |
| | ASH1 | Transcriptional regulatory protein ASH1; Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis. (449 aa) |
| | MET4 | Met4p. (385 aa) |
| | BAS1 | Bas1p. (738 aa) |
| | HAP31 | Hap31p. (105 aa) |
| | CAT8 | DNA-binding transcription factor. (1056 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa) |
| | CaO19.5390 | Uncharacterized protein. (147 aa) |
| | FKH2 | Fork-head transcriptional regulator 2; Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence. (687 aa) |
| | JHD1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (478 aa) |
| | DAL81 | Dal81p. (878 aa) |
| | MTLA1 | Mating-type-like protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating. Belongs to the MATA1 family. (210 aa) |
| | URE2 | Protein URE2; Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity); Belongs to the GST superfamily. (344 aa) |
| | MTLA2 | Mating-type-like protein A2; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of a-specific mating genes; Belongs to the MATA2 family. (201 aa) |
| | CTA8 | Heat shock transcription factor; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. With HSP90, is required for the modulation of the chaperone levels in response to growth temperature, rather than the activation of acute responses to sudden thermal transitions. Activated during infection and contributes to full virulence. Belongs to the HSF family. (760 aa) |
| | RTG1 | Rtg1p. (274 aa) |
| | HCM1 | Hcm1p. (579 aa) |
| | SFU1 | Suppressor of ferric uptake 1; Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice. (517 aa) |
| | WOR1 | White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...] (785 aa) |
| | TEC1 | Transcription activator TEC1; Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tub [...] (743 aa) |
| | STP3 | Transcriptional regulator STP3; Transcription factor that activates genes required for degradation of extracellular protein and uptake of peptides such as the secreted aspartyl protease SAP2 or the oligopeptide transporter OPT1. Required for virulence. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. (436 aa) |
| | CaO19.5930 | FG-nucleoporin. (366 aa) |
| | SFP1 | Zinc-coordinating transcription factor. (445 aa) |
| | TRY4 | Transcriptional regulator of yeast form adherence 4; Transcription factor required for yeast cell adherence to silicone substrate. (286 aa) |
| | WOR2 | White-opaque regulator 2; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth. (446 aa) |
| | RFX2 | RFX-like DNA-binding protein RFX2; Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1; Belongs to the RFX family. (1111 aa) |
| | CAS5 | Cell wall integrity transcriptional regulator CAS5; Transcription factor involved in the cell wall damage response. Acts with ADA2 to promote cell wall integrity. Required for expression of numerous cell wall biosynthesis inhibitor caspofungin- responsive genes. Plays a key role in adherence, hyphal development, and virulence. (821 aa) |
| | SSN2 | Mediator of RNA polymerase II transcription subunit 13; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). (1665 aa) |
| | HSK3 | Hsk3p. (106 aa) |
| | CaO19.4918 | HTH CENPB-type domain-containing protein. (519 aa) |
| | TYE7 | Carbohydrate metabolism regulator TYE7; Key transcriptional regulator of carbohydrate metabolism. Binds the promoter sequences of the glycolytic genes at the CANNTG motif and activates their expression during growth on either fermentable or non-fermentable carbon sources as well as under hypoxic growth conditions. Complete glycolytic activation by GAL4 and TYE7 is required for full virulence. Involved in biofilm formation and negatively regulates hyphal formation under hypoxia. Controls also the expression of the copper transport protein CTR1. (269 aa) |
| | STP2 | Transcriptional regulator STP2; Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyph [...] (584 aa) |
| | CUP2 | Cup2p. (591 aa) |
| | CaO19.5026 | Uncharacterized protein. (1177 aa) |
| | SFL2 | Transcription factor SFL2; Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature. Required for human oral epithelium colonization and damage. Promotes filamentous growth in EFG1- and FLO8-dependent manners. Antagonizes functions of SFL1. Belongs to the HSF family. (714 aa) |
| | CAP1 | AP-1-like transcription factor CAP1; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Involved in the oxidative stress response in via multiple pathways, including the cellular antioxidant defense system, carbohydrate metabolism and energy metabolism, protein degradation, ATP-dependent RNA helicase, and resistance pathways. The ability of the major systemic fungal pathogen of humans to sense and respond to reactive oxygen species, such as H(2)O(2) ge [...] (499 aa) |
| | CaO19.1666 | Uncharacterized protein. (531 aa) |
| | NGG1 | Histone acetyltransferase. (627 aa) |
| | SRB4 | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (565 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (618 aa) |
| | STP4 | Transcriptional regulator STP4; Probable transcription factor involved in response to cell wall damage. (376 aa) |
| | CUP9 | Cup9p. (344 aa) |
| | HIR2 | Protein HIR2; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa) |
| | IFH1 | Transcriptional regulator IFH1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1. (885 aa) |
| | MED14 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1261 aa) |
| | MCM1 | Transcription factor of morphogenesis MCM1; Transcription factor that is recruited by AHR1 to the promoters of genes involved in biofilm formation, which include several key adhesion genes. Plays an important role in cell adhesion, hyphal growth and virulence. Implicated in the regulation of opaque-phase- specific gene expression. (262 aa) |
| | MAC1 | Metal-binding activator 1; Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth. (431 aa) |
| | CaO19.2682 | Transcription initiation factor IIA large subunit. (275 aa) |
| | ADR1 | Transcriptional regulator ADR1; Transcription factor involved in the regulation of hyphal growth. (1418 aa) |
| | MED7 | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (304 aa) |
| | CaO19.307 | Uncharacterized protein. (490 aa) |
| | HIR3 | Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Belongs to the HIR3 family. (1591 aa) |
| | SUS1 | Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (119 aa) |
| | SRB6 | Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (115 aa) |
| | SSN6 | Transcription regulator. (1080 aa) |
| | RPD31 | Histone deacetylase. (577 aa) |
| | SAS2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa) |
| | HIR1 | Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (907 aa) |
| | NDT80 | Transcription factor. (504 aa) |
| | SRB7 | Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (178 aa) |
| | RBF1 | Transcription factor RBF1; Transcriptional activator that binds to the RPG box and to telomeres. Involved in the regulation of the transition between yeast and filamentous forms and plays a role in virulence. Induces expression of HWP1, a major hyphal cell protein and virulence factor. Belongs to the RBF1 family. (534 aa) |
| | RCA1 | Rca1p. (283 aa) |
| | PUT3 | Put3p. (978 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa) |
| | MBF1 | Multiprotein-bridging factor 1; Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. (151 aa) |
| | STB5 | Stb5p. (640 aa) |
| | RME1 | Rme1p. (507 aa) |
| | ADA2 | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa) |
| | SRB5 | Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (351 aa) |
| | SIN3 | Transcriptional regulator. (1411 aa) |
| | HOT1 | GCR1_C domain-containing protein. (607 aa) |
| | ZCF24 | Zcf24p. (701 aa) |
| | SWI4 | SBF complex DNA-binding subunit. (1019 aa) |
| | ARO80 | Aro80p. (1065 aa) |
| | ELA1 | Elongin A. (392 aa) |
| | HAC1 | Transcription factor. (367 aa) |
| | CaO19.6269 | Uncharacterized protein. (861 aa) |
| | HAP2 | Hap2p. (364 aa) |
| | CaO19.5093 | Uncharacterized protein. (352 aa) |
| | SWI6 | Transcriptional regulator. (729 aa) |
| | ARG81 | Arg81p. (1099 aa) |
| | CaO19.4749 | Uncharacterized protein. (558 aa) |
| | ZCF28 | Zcf28p. (247 aa) |
| | LYS143 | Lys143p. (876 aa) |
| | CaO19.4768 | Uncharacterized protein. (531 aa) |
| | CaO19.4911 | BED-type domain-containing protein. (320 aa) |
| | HAP43 | Hap43p. (634 aa) |
| | RTG3 | Rtg3p. (520 aa) |
| | OFI1 | Ofi1p. (648 aa) |
| | CaO19.1496 | Fungal_trans domain-containing protein. (451 aa) |
| | OPI1 | Transcriptional regulator. (432 aa) |
| | ADAEC | Adaecp. (545 aa) |
| | CaO19.4503 | Uncharacterized protein. (225 aa) |
| | CaO19.5210 | HTH APSES-type domain-containing protein. (577 aa) |
| | CaO19.3146 | Uncharacterized protein. (416 aa) |
| | ZCF10 | Zcf10p. (921 aa) |
| | CaO19.217 | Uncharacterized protein. (379 aa) |
| | CaO19.1600 | Uncharacterized protein. (709 aa) |
| | CaO19.1400 | PCI domain-containing protein. (747 aa) |
| | CaO19.1363 | SWIRM domain-containing protein. (392 aa) |
| | RAP1 | DNA-binding transcription factor. (430 aa) |
| | GCN4 | Amino acid starvation-responsive transcription factor. (323 aa) |
| | CaO19.1757 | Uncharacterized protein. (583 aa) |
| | ZCF1 | Zcf1p. (838 aa) |
| | A0A1D8PJT8 | Ubiquinol--cytochrome-c reductase subunit 6. (135 aa) |
| | MBP1 | Transcription factor. (852 aa) |
| | ZCF16 | Zcf16p. (1078 aa) |
| | SNF5 | Snf5p. (696 aa) |
| | TEA1 | Tea1p. (900 aa) |
| | CaO19.7397 | C2H2-type domain-containing protein. (1089 aa) |
| | CaO19.7420 | Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (263 aa) |
| | TAF60 | Taf60p. (519 aa) |
| | NUP159 | FG-nucleoporin. (850 aa) |
| | RLM1 | Rlm1p. (601 aa) |
| | HAP3 | Hap3p. (329 aa) |
| | CaO19.2743 | Uncharacterized protein. (606 aa) |
| | UME7 | DNA-binding transcriptional regulator. (458 aa) |
| | RGT1 | Rgt1p. (1027 aa) |
| | ARG83 | Arg83p. (974 aa) |
| | HFL2 | Negative cofactor 2 transcription regulator complex subunit. (146 aa) |
| | CaO19.2730 | Uncharacterized protein. (606 aa) |
| | MED20 | Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (237 aa) |
| | CSR1 | Csr1p. (618 aa) |
| | SRB8 | Srb8p. (1747 aa) |
| | PHO4 | Phosphate-sensing transcription factor. (659 aa) |
| | ZCF5 | Zcf5p. (971 aa) |
| | A0A1D8PMG2 | Fungal_trans domain-containing protein. (563 aa) |
| | HMS1 | Hms1p. (685 aa) |
| | HAP5 | Hap5p. (348 aa) |
| | FCR3 | Fcr3p. (399 aa) |
| | TAC1 | Tac1p. (981 aa) |
| | ZNC1 | Znc1p. (922 aa) |
| | CaO19.3170 | DUF3835 domain-containing protein. (728 aa) |
| | HAL9 | Hal9p. (1010 aa) |
| | LEU3 | Leucine-responsive transcriptional regulator. (984 aa) |
| | CTA7 | Cta7p. (834 aa) |
| | CaO19.4312 | SAGA complex subunit. (770 aa) |
| | CaO19.6667 | SAP30_Sin3_bdg domain-containing protein. (168 aa) |
| | SUT1 | Sut1p. (356 aa) |
| | CaO19.1111 | Chromatin modification protein. (231 aa) |
| | GLN3 | Nitrogen-responsive transcriptional regulator. (682 aa) |
| | CaO19.3928 | Uncharacterized protein. (380 aa) |
| | PPR1 | Ppr1p. (860 aa) |
| | GRF10 | Grf10p. (685 aa) |
| | CaO19.1189 | NDC10_II domain-containing protein. (684 aa) |
| | CaO19.3643 | Uncharacterized protein. (390 aa) |
| | CaO19.3644 | Uncharacterized protein. (715 aa) |
| | CaO19.132 | Uncharacterized protein. (593 aa) |
| | MED19 | Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (168 aa) |
| | CaO19.7116 | Uncharacterized protein. (317 aa) |
| | CaO19.7067 | Uncharacterized protein. (1091 aa) |
| | MET28 | Met28p. (173 aa) |
| | YOX1 | Yox1p. (335 aa) |
| | CaO19.7023 | PWWP domain-containing protein. (393 aa) |
| | ZCF29 | Zcf29p. (1105 aa) |
| | ZCF38 | Zcf38p. (582 aa) |
| | REP1 | Rep1p. (693 aa) |
| | SAS3 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (805 aa) |
| | KAR4 | Kar4p; Belongs to the MT-A70-like family. (369 aa) |
| | CaO19.3722 | Uncharacterized protein. (849 aa) |
| | CaO19.173 | Uncharacterized protein. (1100 aa) |
| | RPD3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa) |
| | CIRT4B | Cirt4bp. (555 aa) |
| | ZCF11 | Zcf11p. (561 aa) |
| | CaO19.2391 | zf-C2HC5 domain-containing protein. (357 aa) |
| | ZCF19 | Zcf19p. (619 aa) |
| | CaO19.2624 | Uncharacterized protein. (607 aa) |
| | SPT3 | Transcriptional regulator. (328 aa) |
| | TBP1 | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (238 aa) |
| | TUP1 | Transcriptional repressor TUP1; Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of the response to farnesol. Plays an important role in the regulation of white-opaque switching. (512 aa) |
| | SUC1 | Probable sucrose utilization protein SUC1; Affects sucrose utilization and alpha-glucosidase activity. Probable transcriptional activator; Belongs to the MAL13 family. (501 aa) |
| | CPH1 | Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. (656 aa) |
| | ADF1 | Adherence factor; Surface antigen mediating adhesion and aggregation in S.cerevisiae. (612 aa) |
| | PZF1 | Transcription factor IIIA; Transcription factor required for transcription of 5S rRNA by RNA polymerase III. (412 aa) |
| | ASG1 | Activator of stress genes protein 1; Transcription factor necessary to sustain growth on non- fermentative carbon sources such as sodium acetate, acetic acid, or ethanol. Plays a role in hyphal formation. (990 aa) |
| | CWT1 | Cwt1p. (578 aa) |
| | UME6 | Transcriptional regulatory protein UME6; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promo [...] (843 aa) |
