Your Input: | |
| | CaO19.6340 | DNA-directed RNA polymerase core subunit. (214 aa) |
| | SNT1 | Snt1p. (1001 aa) |
| | CDC6 | Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa) |
| | CaO19.4729 | ANK_REP_REGION domain-containing protein. (1381 aa) |
| | TAF145 | Taf145p. (1260 aa) |
| | CaO19.6269 | Uncharacterized protein. (861 aa) |
| | CaO19.426 | Uncharacterized protein. (684 aa) |
| | CaO19.419 | FHA domain-containing protein. (585 aa) |
| | CaO19.6843 | SHNi-TPR domain-containing protein. (373 aa) |
| | CaO19.1041 | CYCLIN domain-containing protein; Belongs to the cyclin family. (495 aa) |
| | ELA1 | Elongin A. (392 aa) |
| | CaO19.3035 | Chromatin-remodeling ATPase. (1410 aa) |
| | CDC73 | Cdc73p. (370 aa) |
| | CaO19.3332 | ArAE_2 domain-containing protein. (992 aa) |
| | RPB11 | DNA-directed RNA polymerase II core subunit. (124 aa) |
| | RRS1 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (205 aa) |
| | SIN3 | Transcriptional regulator. (1411 aa) |
| | CaO19.5297 | TFIIH/NER complex subunit. (631 aa) |
| | CaO19.3373 | Uncharacterized protein. (623 aa) |
| | A0A1D8PLR5 | DNA-directed RNA polymerase core subunit. (72 aa) |
| | MED20 | Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (237 aa) |
| | UME7 | DNA-binding transcriptional regulator. (458 aa) |
| | CaO19.4639 | Uncharacterized protein. (224 aa) |
| | CaO19.4628 | Cleavage polyadenylation factor subunit. (498 aa) |
| | CaO19.4677 | HIT-type domain-containing protein. (236 aa) |
| | MLP1 | Mlp1p. (1832 aa) |
| | MDN1 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5035 aa) |
| | CaO19.7453 | Uncharacterized protein. (273 aa) |
| | TAF60 | Taf60p. (519 aa) |
| | CaO19.7452 | SLD3 domain-containing protein. (736 aa) |
| | CaO19.7444 | TFIIH complex subunit. (341 aa) |
| | CaO19.7442 | UDG domain-containing protein. (298 aa) |
| | A0A1D8PK11 | RNA-binding protein. (227 aa) |
| | CaO19.6952 | Uncharacterized protein. (669 aa) |
| | CaO19.325 | Cleavage and polyadenylation specificity factor subunit 2. (931 aa) |
| | CaO19.314 | Uncharacterized protein. (999 aa) |
| | CaO19.268 | Uncharacterized protein. (447 aa) |
| | CaO19.258 | Uncharacterized protein. (252 aa) |
| | UTP20 | Utp20p. (2500 aa) |
| | HOS2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa) |
| | CaO19.1767 | Ubiquitin carboxyl-terminal hydrolase. (613 aa) |
| | PHO23 | Chromatin modification-related protein. (481 aa) |
| | CaO19.1368 | Uncharacterized protein. (607 aa) |
| | CaO19.1363 | SWIRM domain-containing protein. (392 aa) |
| | CaO19.3625 | Uncharacterized protein. (349 aa) |
| | CaO19.1434 | Protein kinase activating protein. (716 aa) |
| | CaO19.6886 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (416 aa) |
| | CaO19.5213 | CID domain-containing protein. (814 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | RXT3 | Rxt3p. (517 aa) |
| | RPB4 | DNA-directed RNA polymerase II subunit. (268 aa) |
| | CaO19.187 | Uncharacterized protein. (816 aa) |
| | TAF14 | TATA-binding protein-associated factor. (263 aa) |
| | CaO19.808 | Rpd3L histone deacetylase complex subunit. (610 aa) |
| | CaO19.5828 | RRM domain-containing protein. (717 aa) |
| | CaO19.1574 | TAFII55_N domain-containing protein. (588 aa) |
| | OPI1 | Transcriptional regulator. (432 aa) |
| | CaO19.1461 | TauD domain-containing protein. (389 aa) |
| | CaO19.1457 | General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (472 aa) |
| | CaO19.2064 | Uncharacterized protein. (1107 aa) |
| | CaO19.2111 | Transcription factor IIF subunit. (381 aa) |
| | RPC10 | DNA-directed RNA polymerase core subunit. (73 aa) |
| | SET3 | Histone-binding protein. (1069 aa) |
| | ACT1 | Actin. (376 aa) |
| | SPT5 | Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (956 aa) |
| | POB3 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (538 aa) |
| | MHF1 | Inner kinetochore subunit MHF1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity). FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity). Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere- associated network (CCAN), wh [...] (117 aa) |
| | SPT4 | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (112 aa) |
| | ASH2 | Ash2p. (466 aa) |
| | MRD1 | Multiple RNA-binding domain-containing protein 1; Involved in pre-rRNA processing; Belongs to the RRM MRD1 family. (841 aa) |
| | CaO19.1619 | Cyclin-dependent serine/threonine protein kinase. (586 aa) |
| | ARX1 | Probable metalloprotease ARX1; Probable metalloprotease involved in proper assembly of pre- ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity). (564 aa) |
| | SPP1 | Spp1p. (406 aa) |
| | SSN2 | Mediator of RNA polymerase II transcription subunit 13; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). (1665 aa) |
| | RNA14 | mRNA 3'-end-processing protein RNA14; Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (791 aa) |
| | TOA2 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (130 aa) |
| | CaO19.4615 | RXT2_N domain-containing protein. (318 aa) |
| | RFX2 | RFX-like DNA-binding protein RFX2; Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1; Belongs to the RFX family. (1111 aa) |
| | TFG1 | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (608 aa) |
| | CaO19.5989 | Uncharacterized protein. (475 aa) |
| | SEN1 | Putative DNA/RNA helicase. (2018 aa) |
| | CaO19.5910 | Uncharacterized protein. (759 aa) |
| | SBP1 | Sbp1p. (282 aa) |
| | ARP6 | Actin-like protein ARP6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa) |
| | CaO19.4882 | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (284 aa) |
| | TFA1 | Transcription factor TFIIE subunit. (394 aa) |
| | PAPA | Poly(A) polymerase PAPa; Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (By similarity). (555 aa) |
| | CRK1 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. (745 aa) |
| | NGG1 | Histone acetyltransferase. (627 aa) |
| | CaO19.813 | Uncharacterized protein. (692 aa) |
| | YNG2 | Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (298 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa) |
| | FIP1 | Pre-mRNA polyadenylation factor FIP1; Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase; Belongs to the FIP1 family. (326 aa) |
| | BUR2 | Bur2p; Belongs to the cyclin family. (526 aa) |
| | CFT1 | Protein CFT1; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity); Belongs to the CFT1 family. (1420 aa) |
| | PSF3 | DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication. (177 aa) |
| | CaO19.2682 | Transcription initiation factor IIA large subunit. (275 aa) |
| | CaO19.259 | C3H1-type domain-containing protein. (251 aa) |
| | CaO19.307 | Uncharacterized protein. (490 aa) |
| | FESUR1 | Fesur1p; Belongs to the complex I 20 kDa subunit family. (223 aa) |
| | SUS1 | Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (119 aa) |
| | RPD31 | Histone deacetylase. (577 aa) |
| | TAF12 | TFIID_20kDa domain-containing protein. (515 aa) |
| | CaO19.2063 | Uncharacterized protein. (1156 aa) |
| | SAS2 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (352 aa) |
| | SRB7 | Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (178 aa) |
| | SET1 | Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1040 aa) |
| | IPI3 | Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (505 aa) |
| | KIN28 | TFIIH complex serine/threonine-protein kinase subunit; Belongs to the protein kinase superfamily. (343 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (635 aa) |
| | EPL1 | Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (753 aa) |
| | CaO19.2442 | Uncharacterized protein. (234 aa) |
| | HDA1 | Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...] (833 aa) |
| | SRB6 | Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (115 aa) |
| | RPB7 | DNA-directed RNA polymerase II subunit. (173 aa) |
| | CaO19.3349 | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1234 aa) |
| | SKI8 | SKI complex subunit WD repeat protein. (384 aa) |
| | SWC5 | SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (338 aa) |
| | CaO19.3237 | Putative ubiquitin-protein ligase. (1711 aa) |
| | CaO19.3242 | Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (244 aa) |
| | SWD1 | COMPASS subunit protein. (447 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (541 aa) |
| | CaO19.5051 | CENP-T_C domain-containing protein. (756 aa) |
| | EAF7 | Chromatin modification-related protein EAF7; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (445 aa) |
| | RAD27 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (372 aa) |
| | PXR1 | Protein PXR1; Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase; Belongs to the PINX1 family. (276 aa) |
| | FGR29 | Fgr29p. (776 aa) |
| | CaO19.5346 | Uncharacterized protein. (403 aa) |
| | CaO19.5350 | CID domain-containing protein. (290 aa) |
| | CaO19.3428 | PWWP domain-containing protein. (493 aa) |
| | SGF11 | SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (120 aa) |
| | CaO19.1248 | DNA-directed RNA polymerase II core subunit. (318 aa) |
| | NUT2 | Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (170 aa) |
| | UBC9 | E2 SUMO-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (219 aa) |
| | SPT20 | Transcription factor SPT20; Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosom [...] (751 aa) |
| | CDC68 | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa) |
| | VID21 | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (686 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa) |
| | CaO19.3581 | WD_REPEATS_REGION domain-containing protein. (435 aa) |
| | CaO19.2276 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (112 aa) |
| | CaO19.3613 | Uncharacterized protein. (467 aa) |
| | SET2 | Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (844 aa) |
| | PFS2 | Polyadenylation factor subunit 2; Required for 3'-end cleavage and polyadenylation of pre- mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity). (543 aa) |
| | ADA2 | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...] (445 aa) |
| | SLD2 | DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa) |
| | SSU72 | RNA polymerase II subunit A C-terminal domain phosphatase. (226 aa) |
| | SWR1 | Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1641 aa) |
| | TAF4 | Transcription initiation factor TFIID subunit 4; Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of tra [...] (363 aa) |
| | ZCF3 | Zcf3p. (195 aa) |
| | CaO19.4537 | Uncharacterized protein. (305 aa) |
| | CaO19.4538 | RRM domain-containing protein. (276 aa) |
| | CaO19.4542 | TFIIH complex kinase subunit; Belongs to the cyclin family. (395 aa) |
| | YTH1 | mRNA 3'-end-processing protein YTH1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the CPSF4/YTH1 family. (215 aa) |
| | CaO19.6923 | TAFII28 domain-containing protein. (343 aa) |
| | CLP1 | mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (489 aa) |
| | ORC3 | Origin recognition complex subunit 3. (682 aa) |
| | PSF1 | DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (236 aa) |
| | HAT2 | Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. (382 aa) |
| | ELC1 | Elongin C; Belongs to the SKP1 family. (100 aa) |
| | RIX1 | Pre-rRNA-processing protein RIX1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre- 60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1. (769 aa) |
| | RPO26 | DNA-directed RNA polymerase core subunit. (157 aa) |
| | EAF6 | Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (211 aa) |
| | CaO19.29 | CDT1_C domain-containing protein. (323 aa) |
| | SWD2 | WD-repeat containing protein. (364 aa) |
| | CaO19.6623 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (128 aa) |
| | SIN4 | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1053 aa) |
| | FGR12 | Fgr12p. (382 aa) |
| | YSH1 | Endoribonuclease YSH1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. (870 aa) |
| | SPB4 | ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (631 aa) |
| | RPB8 | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (148 aa) |
| | ASF1 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (247 aa) |
| | CaO19.5206 | Hsp90 cochaperone. (509 aa) |
| | UME6 | Transcriptional regulatory protein UME6; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promo [...] (843 aa) |
| | PSF2 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (203 aa) |
| | CaO19.5846 | RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (494 aa) |
| | CaO19.190 | Uncharacterized protein. (324 aa) |
| | YAF9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (254 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (369 aa) |
| | SPT6 | Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1401 aa) |
| | MEX67 | mRNA export factor MEX67; Involved in the export of mRNA from the nucleus to the cytoplasm. (617 aa) |
| | TFB5 | General transcription and DNA repair factor IIH subunit TFB5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (69 aa) |
| | IAH1 | Isoamyl acetate-hydrolyzing esterase. (268 aa) |
| | RPO21 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1728 aa) |
| | SLD5 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (236 aa) |
| | SPT3 | Transcriptional regulator. (328 aa) |
| | CaO19.7594 | Uncharacterized protein. (213 aa) |
| | SPT7 | SAGA histone acetyltransferase complex subunit. (1307 aa) |
| | CaO19.7344 | Uncharacterized protein. (835 aa) |
| | CaO19.7285 | Cleavage polyadenylation factor subunit. (365 aa) |
| | CDC45 | DNA replication initiation factor. (579 aa) |
| | CaO19.1856 | Uncharacterized protein. (340 aa) |
| | ISC1 | Inositol phosphosphingolipid phospholipase. (438 aa) |
| | CaO19.536 | Chromatin modification protein. (798 aa) |
| | CaO19.494 | RNA-binding snoRNP assembly protein. (581 aa) |
| | TAF12L | TFIID_20kDa domain-containing protein. (750 aa) |
| | CaO19.4388 | BTP domain-containing protein. (364 aa) |
| | CaO19.2857 | TFIIH/NER complex ATPase/helicase subunit. (843 aa) |
| | CaO19.2850 | Uncharacterized protein. (1918 aa) |
| | RPD3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa) |
| | SAS3 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (805 aa) |
| | PXA1 | ATP-binding cassette long-chain fatty acid transporter. (765 aa) |
| | UME1 | Ume1p. (485 aa) |
| | CaO19.7197 | Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (745 aa) |
| | TAF19 | Taf19p. (165 aa) |
| | CaO19.6506 | PHD-type domain-containing protein. (688 aa) |
| | CaO19.7041 | RNA-processing protein. (764 aa) |
| | RTF1 | Rtf1p. (568 aa) |
| | CaO19.7067 | Uncharacterized protein. (1091 aa) |
| | CaO19.7074 | SGF29 C-terminal domain-containing protein. (265 aa) |
| | CaO19.7116 | Uncharacterized protein. (317 aa) |
| | RAD3 | TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit. (765 aa) |
| | TSM1 | Tsm1p. (1425 aa) |
| | NOG2 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (533 aa) |
| | CaO19.5617 | PHD domain-containing protein. (479 aa) |
| | CaO19.3473 | Deubiquitination module subunit. (549 aa) |
| | SWD3 | Swd3p. (383 aa) |
| | CaO19.3399 | YL1_C domain-containing protein. (764 aa) |
| | CaO19.684 | CID domain-containing protein. (516 aa) |
| | TRA1 | Histone acetyltransferase; Belongs to the PI3/PI4-kinase family. (3821 aa) |
| | CaO19.132 | Uncharacterized protein. (593 aa) |
| | CaO19.4194 | TFIIH/NER complex subunit. (363 aa) |
| | CaO19.3970 | Uncharacterized protein. (246 aa) |
| | SDC1 | Sdc1p. (128 aa) |
| | CaO19.1111 | Chromatin modification protein. (231 aa) |
| | CaO19.6667 | SAP30_Sin3_bdg domain-containing protein. (168 aa) |
| | CaO19.4312 | SAGA complex subunit. (770 aa) |
| | TFB3 | TFIIH/NER complex subunit. (360 aa) |
| | CaO19.3084 | SAS4 domain-containing protein. (293 aa) |
| | HOS1 | Histone deacetylase. (436 aa) |
| | SRB8 | Srb8p. (1747 aa) |
