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| | SPC2 | Signal peptidase complex subunit. (169 aa) |
| | SEC61 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). (479 aa) |
| | GPI7 | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity). Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily. (885 aa) |
| | CaO19.4738 | SUN domain-containing protein. (558 aa) |
| | CaO19.4566 | Protein ROT1; Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies; Belongs to the ROT1 family. (193 aa) |
| | AGP2 | Agp2p. (568 aa) |
| | STT3 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit. (751 aa) |
| | SPC3 | Signal peptidase subunit 3. (192 aa) |
| | LCB2 | Serine C-palmitoyltransferase. (569 aa) |
| | TIP1 | Protein YIP. (251 aa) |
| | CaO19.3994 | Dolichyl-diphosphooligosaccharide--protein glycotransferase. (396 aa) |
| | ALG8 | Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG6/ALG8 glucosyltransferase family. (587 aa) |
| | SEC62 | Translocation protein SEC62; Required for preprotein translocation. (293 aa) |
| | CaO19.3060 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (275 aa) |
| | CaO19.6552 | Sulfhydryl oxidase. (254 aa) |
| | GPI11 | Glycosylphosphatidylinositol anchor biosynthesis protein 11; Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein. (265 aa) |
| | CaO19.2698 | Uncharacterized protein. (108 aa) |
| | CaO19.351 | Uncharacterized protein. (155 aa) |
| | PMT2 | Dolichyl-phosphate-mannose--protein mannosyltransferase 2; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Essential protein that plays an important role in virulence. Belongs to the glycosyltransferase 39 family. (769 aa) |
| | ERG28 | Erg28p. (138 aa) |
| | CaO19.2045 | Diacylglycerol kinase. (345 aa) |
| | PMT5 | Dolichyl-phosphate-mannose--protein mannosyltransferase 5; Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P- mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation. (725 aa) |
| | ROT1 | Protein ROT1; Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity); Belongs to the ROT1 family. (260 aa) |
| | ALG13 | UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity). Belongs to the glycosyltransferase 28 family. (293 aa) |
| | PSD1 | Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Important for virulence. (590 aa) |
| | CaO19.6264 | DUF2012 domain-containing protein. (238 aa) |
| | CHS7 | Chitin synthase export chaperone; Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum. (310 aa) |
| | GPI15 | Phosphatidylinositol N-acetylglucosaminyltransferase. (205 aa) |
| | CaO19.3307 | N,N-dimethylaniline monooxygenase; Belongs to the FMO family. (463 aa) |
| | ORM1 | Sphingolipid homeostasis protein. (268 aa) |
| | LAG1 | Sphingosine N-acyltransferase. (412 aa) |
| | SEC11 | Signal peptidase complex catalytic subunit SEC11; Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity). (166 aa) |
| | SPT14 | Phosphatidylinositol N-acetylglucosaminyltransferase. (452 aa) |
| | GPI2 | Phosphatidylinositol N-acetylglucosaminyltransferase. (304 aa) |
| | CaO19.3843 | Sec63 complex subunit. (268 aa) |
| | MRP8 | Mrp8p. (205 aa) |
| | ALG14 | UDP-N-acetylglucosamine transferase subunit ALG14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity). (219 aa) |
| | CaO19.6379 | Uncharacterized protein. (152 aa) |
| | CaO19.6416 | Uncharacterized protein. (465 aa) |
| | CaO19.6438 | Serine C-palmitoyltransferase. (587 aa) |
| | ERF4 | Ras modification protein ERF4; The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity). (218 aa) |
| | ERG26 | Sterol-4-alpha-carboxylate 3-dehydrogenase (Decarboxylating). (350 aa) |
| | CaO19.3135 | UBX domain-containing protein. (593 aa) |
| | SUR2 | Sphingosine hydroxylase; Belongs to the sterol desaturase family. (342 aa) |
| | CaO19.5833 | Polyubiquitin-binding protein. (363 aa) |
| | DIE2 | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol; Belongs to the ALG10 glucosyltransferase family. (450 aa) |
| | PMT4 | Dolichyl-phosphate-mannose--protein mannosyltransferase 4; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of AXL2, responsible for bud site selection, as well as of the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for biofilm formation. [...] (755 aa) |
| | CDC48 | AAA family ATPase; Belongs to the AAA ATPase family. (826 aa) |
| | CWH8 | Cwh8p. (241 aa) |
| | CaO19.3859 | Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (349 aa) |
| | CaO19.1407 | Uncharacterized protein. (446 aa) |
| | CaO19.1158 | Uncharacterized protein. (297 aa) |
| | SEC72 | Sec63 complex subunit. (204 aa) |
| | CaO19.2677 | GPI-anchor transamidase subunit. (621 aa) |
| | ALG11 | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity); Belongs to the glycosyltransferase group 1 family. (609 aa) |
| | CaO19.640 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (237 aa) |
| | ERF2 | Palmitoyltransferase ERF2; The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. (514 aa) |
| | SPF1 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1223 aa) |
| | GPI8 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (383 aa) |
| | CUE1 | Coupling of ubiquitin conjugation to ER degradation protein 1; Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of mem [...] (189 aa) |
| | SNL1 | Snl1p. (199 aa) |
| | CaO19.6284 | Signal recognition particle receptor subunit beta. (305 aa) |
| | CDC25 | Cell division control protein 25; Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered. (1333 aa) |
| | PMT1 | Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of the cell wall proteins KRE9, PIR2, RHD3, and ALS1, as well as the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for filamentatio [...] (877 aa) |
| | ERG25 | Methylsterol monooxygenase; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (308 aa) |
| | CaO19.5156 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (200 aa) |
| | CaO19.7672 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (331 aa) |
| | CaO19.7670 | Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (923 aa) |
| | VMA22 | Vma22p. (188 aa) |
| | CaO19.7329 | E2 ubiquitin-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa) |
| | FGR32 | Fgr32p. (773 aa) |
| | CaO19.6117 | Uncharacterized protein. (446 aa) |
| | CaO19.719 | E3 ubiquitin-protein ligase. (633 aa) |
| | SEC63 | Protein-transporting protein. (673 aa) |
| | CaO19.2378 | Uncharacterized protein. (117 aa) |
| | ALG5 | Dolichyl-phosphate beta-glucosyltransferase. (323 aa) |
| | CaO19.3730 | Uncharacterized protein. (135 aa) |
| | A0A1D8PRY9 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (95 aa) |
| | CaO19.7183 | ER membrane protein complex subunit 4; Belongs to the EMC4 family. (176 aa) |
| | CaO19.7173 | Uncharacterized protein. (573 aa) |
| | HLJ1 | Type I HSP40 co-chaperone. (331 aa) |
| | CYR1 | Adenylate cyclase. (1690 aa) |
| | CaO19.5175 | E3 ubiquitin-protein ligase. (1139 aa) |
| | CaO19.6462 | ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. (261 aa) |
| | CYB5 | Cyb5p; Belongs to the cytochrome b5 family. (126 aa) |
| | CaO19.7078 | Uncharacterized protein. (153 aa) |
| | CaO19.5539 | SNAP receptor. (280 aa) |
| | CaO19.120 | Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (257 aa) |
| | CaO19.119 | Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (265 aa) |
| | CaO19.3658 | Uncharacterized protein. (647 aa) |
| | CaO19.1191 | Ubiquitin ligase complex subunit. (806 aa) |
| | SRP101 | Signal recognition particle receptor subunit alpha. (535 aa) |
| | CaO19.3949 | Bromo domain-containing protein. (1314 aa) |
| | CaO19.3939 | Uncharacterized protein. (302 aa) |
| | A0A1D8PNY0 | Uncharacterized protein. (89 aa) |
| | CaO19.4341 | GPI-anchor transamidase subunit. (482 aa) |
| | CaO19.4247 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (315 aa) |
| | CaO19.4131 | EMC1_C domain-containing protein. (861 aa) |
| | CaO19.5693 | GPI-anchor transamidase subunit. (547 aa) |
| | CWH41 | Cwh41p. (830 aa) |
| | RCE1 | CAAX prenyl protease. (281 aa) |
| | CaO19.5291 | Uncharacterized protein. (320 aa) |
| | CaO19.5300 | Calnexin. (581 aa) |
| | CaO19.6082 | Uncharacterized protein. (384 aa) |
| | CaO19.3293 | Trans-2-enoyl-CoA reductase (NADPH). (312 aa) |
| | HMG1 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1073 aa) |
| | SSH1 | Ssh1p; Belongs to the SecY/SEC61-alpha family. (499 aa) |
| | HAC1 | Transcription factor. (367 aa) |
| | IRE1 | Bifunctional endoribonuclease/protein kinase. (1223 aa) |
| | CaO19.4787 | J domain-containing protein. (730 aa) |
| | SAC1 | Phosphatidylinositol-3-phosphatase. (618 aa) |
| | WBP1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (437 aa) |
| | CaO19.1160 | Uncharacterized protein. (215 aa) |
| | VPH2 | Vph2p. (213 aa) |
| | WSC4 | Wsc4p. (491 aa) |
| | A0A1D8PGP8 | Uncharacterized protein. (96 aa) |
| | GPI19 | Phosphatidylinositol N-acetylglucosaminyltransferase. (298 aa) |
| | CaO19.2257 | Uncharacterized protein. (367 aa) |
| | ALG7 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase. (494 aa) |
| | SPT23 | Protein phosphatase; Belongs to the PP2C family. (742 aa) |
| | CaO19.1761 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (171 aa) |
| | A0A1D8PIU6 | Uncharacterized protein. (82 aa) |
| | ERG4 | Delta(24(24(1)))-sterol reductase. (469 aa) |
| | CaO19.261 | Dolichol kinase. (586 aa) |
| | NSG2 | Uncharacterized protein. (334 aa) |
| | OST1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (470 aa) |
| | LAC1 | Lac1p. (427 aa) |
| | CaO19.7364 | Uncharacterized protein; Belongs to the FMO family. (536 aa) |
| | GPI1 | Phosphatidylinositol N-acetylglucosaminyltransferase. (648 aa) |
| | UBP1 | Ubiquitin carboxyl-terminal hydrolase. (804 aa) |
| | CaO19.7347 | E2 ubiquitin-conjugating protein. (243 aa) |
| | A0A1D8PKK1 | Translocon subunit. (68 aa) |
| | CaO19.7426 | Dolichyl-diphosphooligosaccharide--protein glycotransferase. (340 aa) |
| | CaO19.6787 | Cornichon family protein. (137 aa) |
| | STE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (445 aa) |
| | ERG251 | Erg251p; Belongs to the sterol desaturase family. (321 aa) |
