(40 nodes) PH-like domain superfamily network (Candida albicans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CaO19.4245	Uncharacterized protein. (448 aa)
	CDC24	Rho family guanine nucleotide exchange factor. (844 aa)
	GYP2	Gyp2p. (942 aa)
	CaO19.5297	TFIIH/NER complex subunit. (631 aa)
	BEM3	Bem3p. (1141 aa)
	CaO19.3583	RanBD1 domain-containing protein. (385 aa)
	VPS36	ESCRT-II subunit protein. (665 aa)
	CaO19.5221	CRIM domain-containing protein. (983 aa)
	CaO19.5274	PH domain-containing protein. (1021 aa)
	CaO19.4744	Phosphatidylinositol-3-phosphatase. (735 aa)
	CLA4	Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (976 aa)
	CaO19.1527	Uncharacterized protein. (184 aa)
	POB3	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (538 aa)
	CaO19.4043	PH domain-containing protein. (752 aa)
	LOT5	Protein LOT5. (252 aa)
	ROM2	Rho family guanine nucleotide exchange factor. (1381 aa)
	ATG26	Sterol 3-beta-glucosyltransferase; Probable sterol 3-beta-glucosyltransferase that is not involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy (By similarity). (1512 aa)
	PSY2	Psy2p. (980 aa)
	CaO19.423	Uncharacterized protein. (185 aa)
	CDC68	FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1060 aa)
	EXO84	Exocyst complex component EXO84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity). (791 aa)
	OSH3	Oxysterol-binding protein related protein; Belongs to the OSBP family. (844 aa)
	RTT106	Histone chaperone RTT106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). (409 aa)
	BUD4	Bud site selection protein BUD4; Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis. Belongs to the BUD4 family. (1709 aa)
	WAL1	Actin-binding protein. (713 aa)
	BOI2	Boi2p. (1172 aa)
	YRB1	Ran GTPase-binding protein. (212 aa)
	CaO19.6705	Arf family guanine nucleotide exchange factor. (1045 aa)
	CaO19.2129	PH domain-containing protein. (833 aa)
	SLM2	Phosphatidylinositol 4,5-bisphosphate-binding protein. (798 aa)
	CaO19.90	VASt domain-containing protein. (754 aa)
	CaO19.1285	SMP-LTD domain-containing protein. (931 aa)
	CaO19.6660	Uncharacterized protein. (513 aa)
	CaO19.6665	Nucleoporin. (792 aa)
	CaO19.3047	Uncharacterized protein. (1209 aa)
	CaO19.5095	Oxysterol-binding protein related protein; Belongs to the OSBP family. (1318 aa)
	CaO19.4423	VASt domain-containing protein. (1073 aa)
	BPH1	Bph1p. (2273 aa)
	TUS1	Rho family guanine nucleotide exchange factor. (1397 aa)
	AGE1	Age1p. (958 aa)

Your Current Organism:

Candida albicans

NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BEM3	BOI2	A0A1D8PLJ2	A0A1D8PRW9	Bem3p.	Boi2p.	0.452
BEM3	CDC24	A0A1D8PLJ2	A0A1D8PNB5	Bem3p.	Rho family guanine nucleotide exchange factor.	0.796
BEM3	CLA4	A0A1D8PLJ2	Q5APR8	Bem3p.	Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	0.424
BOI2	BEM3	A0A1D8PRW9	A0A1D8PLJ2	Boi2p.	Bem3p.	0.452
BOI2	CDC24	A0A1D8PRW9	A0A1D8PNB5	Boi2p.	Rho family guanine nucleotide exchange factor.	0.746
BOI2	CaO19.5095	A0A1D8PRW9	A0A1D8PE79	Boi2p.	Oxysterol-binding protein related protein; Belongs to the OSBP family.	0.408
BOI2	VPS36	A0A1D8PRW9	A0A1D8PH22	Boi2p.	ESCRT-II subunit protein.	0.429
BUD4	CLA4	P53705	Q5APR8	Bud site selection protein BUD4; Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis. Belongs to the BUD4 family.	Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	0.439
BUD4	WAL1	P53705	A0A1D8PU03	Bud site selection protein BUD4; Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis. Belongs to the BUD4 family.	Actin-binding protein.	0.451
CDC24	BEM3	A0A1D8PNB5	A0A1D8PLJ2	Rho family guanine nucleotide exchange factor.	Bem3p.	0.796
CDC24	BOI2	A0A1D8PNB5	A0A1D8PRW9	Rho family guanine nucleotide exchange factor.	Boi2p.	0.746
CDC24	CLA4	A0A1D8PNB5	Q5APR8	Rho family guanine nucleotide exchange factor.	Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	0.645
CDC24	ROM2	A0A1D8PNB5	Q5AH90	Rho family guanine nucleotide exchange factor.	Rho family guanine nucleotide exchange factor.	0.509
CDC24	TUS1	A0A1D8PNB5	A0A1D8PDA9	Rho family guanine nucleotide exchange factor.	Rho family guanine nucleotide exchange factor.	0.608
CDC68	CaO19.5297	Q5A1D5	A0A1D8PLZ6	FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	TFIIH/NER complex subunit.	0.631
CDC68	POB3	Q5A1D5	Q5ALL8	FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.999
CDC68	RTT106	Q5A1D5	Q59S27	FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	Histone chaperone RTT106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).	0.670
CLA4	BEM3	Q5APR8	A0A1D8PLJ2	Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Bem3p.	0.424
CLA4	BUD4	Q5APR8	P53705	Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Bud site selection protein BUD4; Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis. Belongs to the BUD4 family.	0.439
CLA4	CDC24	Q5APR8	A0A1D8PNB5	Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Rho family guanine nucleotide exchange factor.	0.645