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| | SEC6 | SNARE-binding exocyst subunit. (819 aa) |
| | SIN3 | Transcriptional regulator. (1411 aa) |
| | ESP1 | Separase. (1598 aa) |
| | SWI4 | SBF complex DNA-binding subunit. (1019 aa) |
| | TEM1 | Ras family GTPase. (200 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa) |
| | CDC3 | Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (428 aa) |
| | PHO85 | Cyclin-dependent serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (332 aa) |
| | TUS1 | Rho family guanine nucleotide exchange factor. (1397 aa) |
| | BUD6 | Bud6p. (703 aa) |
| | PCL2 | Cyclin. (254 aa) |
| | SWI6 | Transcriptional regulator. (729 aa) |
| | CDC6 | Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa) |
| | ACT1 | Actin. (376 aa) |
| | BUB2 | Bub2p. (314 aa) |
| | STE11 | Mitogen-activated protein kinase kinase kinase. (823 aa) |
| | STE4 | G protein subunit beta. (457 aa) |
| | CDC15 | Serine/threonine protein kinase. (1126 aa) |
| | LEM3 | Lem3p; Belongs to the CDC50/LEM3 family. (439 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | LTE1 | Mitotic regulator. (1651 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | CaO19.2222 | Casein kinase; Belongs to the protein kinase superfamily. (378 aa) |
| | SPO11 | Spo11p. (309 aa) |
| | MIH1 | Putative tyrosine protein phosphatase. (894 aa) |
| | RAD50 | MRX complex DNA-binding subunit. (1332 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1237 aa) |
| | DDC1 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (488 aa) |
| | RAD53 | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa) |
| | YCK2 | Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa) |
| | ASE1 | Ase1p. (906 aa) |
| | BEM1 | Phosphatidylinositol-3-phosphate-binding protein. (632 aa) |
| | HOS3 | Histone deacetylase. (713 aa) |
| | BEM3 | Bem3p. (1141 aa) |
| | BUB1 | Protein kinase. (900 aa) |
| | SEC15 | Exocyst complex component SEC15; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (892 aa) |
| | TUB4 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (498 aa) |
| | SEC10 | Exocyst subunit. (785 aa) |
| | EXO1 | Rad2 family nuclease. (699 aa) |
| | CDC24 | Rho family guanine nucleotide exchange factor. (844 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa) |
| | SST2 | GTPase-activating protein. (675 aa) |
| | DUN1 | Serine/threonine protein kinase. (530 aa) |
| | DNA2 | Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa) |
| | SEC8 | Exocyst subunit. (1107 aa) |
| | CDC20 | Ubiquitin-protein transferase activating protein. (634 aa) |
| | SEC5 | Exocyst complex component SEC5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (959 aa) |
| | YOX1 | Yox1p. (335 aa) |
| | STE18 | Ste18p. (90 aa) |
| | WHI3 | mRNA-binding protein. (704 aa) |
| | BOI2 | Boi2p. (1172 aa) |
| | CDC27 | Anaphase promoting complex subunit. (875 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | RPD3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa) |
| | YDJ1 | Type I HSP40 co-chaperone. (393 aa) |
| | STE2 | Alpha-factor pheromone receptor. (469 aa) |
| | CDC45 | DNA replication initiation factor. (579 aa) |
| | CHS2 | Chitin synthase. (1009 aa) |
| | MPS1 | Serine/threonine/tyrosine protein kinase. (690 aa) |
| | AXL1 | Axl1p. (1370 aa) |
| | DPB2 | DNA polymerase epsilon noncatalytic subunit. (708 aa) |
| | CDC11 | Septin CDC11; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins b [...] (402 aa) |
| | RHO1 | GTP-binding protein RHO1. (198 aa) |
| | CDC42 | Cell division control protein 42 homolog; Involved in hyphal formation, virulence, morphogenesis; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (191 aa) |
| | SSA1 | Heat shock protein SSA1; May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. (656 aa) |
| | CDC28 | Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa) |
| | CPH1 | Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. (656 aa) |
| | SSA2 | Heat shock protein SSA2; May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. (645 aa) |
| | BUD4 | Bud site selection protein BUD4; Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis. Belongs to the BUD4 family. (1709 aa) |
| | DBF2 | Cell cycle protein kinase DBF2; Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Required for proper nuclear segregation, mitotic spindle organization, actomyosin ring contraction, primary septum assembly, and normal hyphal morphogenesis. (710 aa) |
| | ESS1 | Peptidyl-prolyl cis-trans isomerase. (177 aa) |
| | CSE4 | Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (211 aa) |
| | CKS1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (102 aa) |
| | MEC1 | Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2325 aa) |
| | RAD52 | Recombinase. (564 aa) |
| | CDC14 | Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa) |
| | YBL053 | Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1263 aa) |
| | MEC3 | Checkpoint protein; Belongs to the HUS1 family. (319 aa) |
| | GCN5 | Histone acetyltransferase. (449 aa) |
| | BUB3 | Bub3p. (373 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa) |
| | IPL1 | Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (528 aa) |
| | ORC3 | Origin recognition complex subunit 3. (682 aa) |
| | FUS1 | Fus1p. (384 aa) |
| | SLD2 | DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (354 aa) |
| | SEP7 | Septation protein 7; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many pro [...] (670 aa) |
| | GAL1 | Galactokinase. (515 aa) |
| | FIG1 | Fig1p. (265 aa) |
| | CSM3 | Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (316 aa) |
| | EXO84 | Exocyst complex component EXO84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity). (791 aa) |
| | CCN1 | G1/S-specific cyclin CCN1; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth. (693 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | CLB4 | G2/mitotic-specific cyclin-4; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. (486 aa) |
| | CLN3 | G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics. (465 aa) |
| | CDC23 | Anaphase promoting complex subunit. (582 aa) |
| | SKN7 | Transcription factor SKN7; Transcription factor that is part of a SLN1-YPD1-SKN7 two- component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes. (559 aa) |
| | BUD2 | GTPase activating protein BUD2; GTPase activating protein (GAP) for RSR1 which is involved in the polarization of yeast and hyphal cells. Directs the site of new daughter cell growth in yeast and hyphal cells. Important for hyphae to maintain linear growth and necessary for hyphal responses to directional cues in the environment (tropisms). Required for correct localization of the septin rings and stabilization of the polarisome at hyphal tips. Involved in cell adhesion. (1237 aa) |
| | DBF4 | Protein serine/threonine kinase activating protein. (506 aa) |
| | SGS1 | ATP-dependent DNA helicase. (1189 aa) |
| | BAS1 | Bas1p. (738 aa) |
| | RAD27 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (372 aa) |
| | HST7 | Serine/threonine-protein kinase STE7 homolog. (589 aa) |
| | FKH2 | Fork-head transcriptional regulator 2; Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence. (687 aa) |
| | BNR1 | Formin BNR1; May organize microtubules by mediating spindle positioning and movement in the budding process. Required for cytokinesis and the maintenance of polarized hyphal growth; Belongs to the formin homology family. BNI1 subfamily. (1485 aa) |
| | KIN28 | TFIIH complex serine/threonine-protein kinase subunit; Belongs to the protein kinase superfamily. (343 aa) |
| | CDC5 | Serine/threonine-protein kinase. (653 aa) |
| | LYS14 | Lys14p. (592 aa) |
| | MOB1 | Mob1p. (273 aa) |
| | HTZ1 | Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa) |
| | BEM2 | Bem2p. (2252 aa) |
| | SMC6 | DNA repair protein. (1128 aa) |
| | EXO70 | Exocyst complex protein EXO70; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity). Belongs to the EXO70 family. (667 aa) |
| | SEC1 | Sec1p; Belongs to the STXBP/unc-18/SEC1 family. (779 aa) |
| | YNG2 | Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (298 aa) |
| | SSN3 | Serine/threonine-protein kinase SSN3; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity). (608 aa) |
| | MYO2 | Myosin 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1561 aa) |
| | KAR9 | Kar9p. (758 aa) |
| | SEC2 | Rab guanine nucleotide exchange factor SEC2; Guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP. Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis (By similarity). Required for filamentous growth. (751 aa) |
| | BNI1 | Formin BNI1; Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Required for the maintenance of polarized hyphal growth. BNI1-mediated actin cables are necessary for positioni [...] (1732 aa) |
| | SMP2 | Phosphatidate phosphatase. (781 aa) |
| | CLB2 | G2/mitotic-specific cyclin CLB2; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54. (492 aa) |
| | ASK1 | Ask1p. (594 aa) |
| | RGA2 | Rga2p. (1176 aa) |
| | TEC1 | Transcription activator TEC1; Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tub [...] (743 aa) |
| | PKC1 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1097 aa) |
| | CBK1 | Serine/threonine-protein kinase CBK1; Serine/threonine-protein kinase required for wild-type hyphal growth and transcriptional regulation of cell-wall-associated genes. Involved in the biofilm formation through phosphorylation of the master regulator of biofilm formation BCR1. (732 aa) |
| | SWE1 | Mitosis inhibitor protein kinase SWE1; Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-18'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Plays an important role in filamentous growth. (1178 aa) |
| | HCM1 | Hcm1p. (579 aa) |
| | CLA4 | Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (976 aa) |
| | CRK1 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. (745 aa) |
