18 items (Candida albicans) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	CZF1	Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...] (385 aa)
	RAD50	MRX complex DNA-binding subunit. (1332 aa)
	VMA6	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family. (348 aa)
	CaO19.4629	Ubiquitin-ubiquitin ligase. (965 aa)
	RBT7	Rbt7p; Belongs to the RNase T2 family. (325 aa)
	CaO19.5525	Uncharacterized protein. (348 aa)
	ERG11	Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol. (528 aa)
	PHR1	pH-responsive protein 1; Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism. (548 aa)
	LIG4	DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae. (928 aa)
	RAD52	Recombinase. (564 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa)
	RAD51	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
	GAL1	Galactokinase. (515 aa)
	VID21	Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (686 aa)
	GCD11	Translation initiation factor eIF2 subunit gamma. (534 aa)
	MNN42	Uncharacterized protein. (838 aa)
	RAD54	DNA-dependent ATPase. (848 aa)
	RPL10A	60S ribosomal protein L10a; Belongs to the universal ribosomal protein uL1 family. (217 aa)

Your Current Organism:

Candida albicans

NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CaO19.4629	CaO19.5525	A0A1D8PLC1	A0A1D8PPX6	Ubiquitin-ubiquitin ligase.	Uncharacterized protein.	0.677
CaO19.4629	GCD11	A0A1D8PLC1	Q5AGF6	Ubiquitin-ubiquitin ligase.	Translation initiation factor eIF2 subunit gamma.	0.439
CaO19.4629	RAD52	A0A1D8PLC1	Q59NG2	Ubiquitin-ubiquitin ligase.	Recombinase.	0.502
CaO19.4629	RBT7	A0A1D8PLC1	A0A1D8PLR0	Ubiquitin-ubiquitin ligase.	Rbt7p; Belongs to the RNase T2 family.	0.515
CaO19.4629	RPL10A	A0A1D8PLC1	Q9UVJ4	Ubiquitin-ubiquitin ligase.	60S ribosomal protein L10a; Belongs to the universal ribosomal protein uL1 family.	0.437
CaO19.4629	VID21	A0A1D8PLC1	Q5A119	Ubiquitin-ubiquitin ligase.	Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).	0.509
CaO19.5525	CaO19.4629	A0A1D8PPX6	A0A1D8PLC1	Uncharacterized protein.	Ubiquitin-ubiquitin ligase.	0.677
CaO19.5525	GAL1	A0A1D8PPX6	Q59VY8	Uncharacterized protein.	Galactokinase.	0.588
CaO19.5525	GCD11	A0A1D8PPX6	Q5AGF6	Uncharacterized protein.	Translation initiation factor eIF2 subunit gamma.	0.684
CaO19.5525	MNN42	A0A1D8PPX6	Q5AHE5	Uncharacterized protein.	Uncharacterized protein.	0.605
CaO19.5525	RPL10A	A0A1D8PPX6	Q9UVJ4	Uncharacterized protein.	60S ribosomal protein L10a; Belongs to the universal ribosomal protein uL1 family.	0.680
CaO19.5525	VID21	A0A1D8PPX6	Q5A119	Uncharacterized protein.	Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).	0.831
CaO19.5525	VMA6	A0A1D8PPX6	A0A1D8PKX3	Uncharacterized protein.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family.	0.641
GAL1	CaO19.5525	Q59VY8	A0A1D8PPX6	Galactokinase.	Uncharacterized protein.	0.588
GCD11	CaO19.4629	Q5AGF6	A0A1D8PLC1	Translation initiation factor eIF2 subunit gamma.	Ubiquitin-ubiquitin ligase.	0.439
GCD11	CaO19.5525	Q5AGF6	A0A1D8PPX6	Translation initiation factor eIF2 subunit gamma.	Uncharacterized protein.	0.684
GCD11	RPL10A	Q5AGF6	Q9UVJ4	Translation initiation factor eIF2 subunit gamma.	60S ribosomal protein L10a; Belongs to the universal ribosomal protein uL1 family.	0.659
GCD11	VID21	Q5AGF6	Q5A119	Translation initiation factor eIF2 subunit gamma.	Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).	0.611
GCD11	VMA6	Q5AGF6	A0A1D8PKX3	Translation initiation factor eIF2 subunit gamma.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family.	0.410
LIG4	PIF1	P52496	Q59RQ0	DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.510