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LCB4 LCB4 PDR16 PDR16 GSL1 GSL1 CDR4 CDR4 SAM4 SAM4 ACT1 ACT1 FTR1 FTR1 ADAEC ADAEC WH11 WH11 RTA3 RTA3 GCN4 GCN4 YOR1 YOR1 OPT7 OPT7 CaO19.3769 CaO19.3769 MNN4 MNN4 GPR1 GPR1 TAC1 TAC1 FET34 FET34 EBP1 EBP1 GSL2 GSL2 HSP104 HSP104 RTA4 RTA4 ERG11 ERG11 CBP1 CBP1 ADF1 ADF1 CDR2 CDR2 ECE1 ECE1 SRR1 SRR1 UPC2 UPC2 GAP4 GAP4 EFG1 EFG1 CZF1 CZF1 SIT1 SIT1 HGT10 HGT10 ALS1 ALS1 ZPR1 ZPR1 MDR1 MDR1 SMF3 SMF3 WOR4 WOR4 SCH9 SCH9 CAP1 CAP1 SFL2 SFL2 CDR1 CDR1 WOR2 WOR2 WOR1 WOR1 HOG1 HOG1 MET3 MET3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LCB4Sphinganine kinase. (530 aa)
PDR16Phosphatidylinositol transporter. (369 aa)
GSL1Gsl1p. (1571 aa)
CDR4Cdr4p; Belongs to the ABC transporter superfamily. (1490 aa)
SAM4S-adenosylmethionine-homocysteine S-methyltransferase. (311 aa)
ACT1Actin. (376 aa)
FTR1High-affinity iron permease. (381 aa)
ADAECAdaecp. (545 aa)
WH11Wh11p. (65 aa)
RTA3Rta3p. (464 aa)
GCN4Amino acid starvation-responsive transcription factor. (323 aa)
YOR1ATP-binding cassette transporter. (1488 aa)
OPT7Opt7p. (747 aa)
CaO19.3769Zn(2+) transporter. (687 aa)
MNN4Mnn4p. (996 aa)
GPR1Gpr1p. (823 aa)
TAC1Tac1p. (981 aa)
FET34Ferroxidase; Belongs to the multicopper oxidase family. (625 aa)
EBP1Ebp1p. (407 aa)
GSL2Gsl2p. (1640 aa)
HSP104Chaperone ATPase; Belongs to the ClpA/ClpB family. (899 aa)
RTA4Rta4p. (456 aa)
ERG11Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol. (528 aa)
CBP1Corticosteroid-binding protein; May be a flavoprotein with enzymatic activity. (489 aa)
ADF1Adherence factor; Surface antigen mediating adhesion and aggregation in S.cerevisiae. (612 aa)
CDR2Multidrug resistance protein CDR2; Multidrug efflux transporter. Confers resistance to azole antifungal agents, to other antifungals (terbinafine, amorolfine) and to a variety of metabolic inhibitors; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1499 aa)
ECE1Extent of cell elongation protein 1; Secreted protein involved in biofilm formation. Further cleaved by KEX2 in 8 similar peptides (ECE1- I to ECE1-VIII). (271 aa)
SRR1Stress response regulator protein 1; Required for stress adaptation, morphogenesis and virulence. (282 aa)
UPC2Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping. (712 aa)
GAP4S-adenosylmethionine permease GAP4; Amino-acid permease involved in S-adenosylmethionine (SAM) transport and required for SAM-induced morphogenesis. GAP4 is also able to transport arginine and thialysine, and thus probably also lysine. (607 aa)
EFG1Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] (550 aa)
CZF1Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...] (385 aa)
SIT1Siderophore transporter. (604 aa)
HGT10Glucose-inactivated glycerol proton symporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (546 aa)
ALS1Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. (1260 aa)
ZPR1Zinc finger-containing protein. (509 aa)
MDR1Multidrug resistance protein 1; Plasma membrane multidrug efflux pump that confers resistance to numerous chemicals including azoles such as fluconazole, voriconazole, and benztriazoles, as well as to benomyl, cycloheximide, methotrexate, 4-nitroquinoline-N-oxide, sulfometuron methyl, cerulenin, and brefeldin A. Belongs to the major facilitator superfamily. CAR1 family. (564 aa)
SMF3Putative divalent metal ion transporter. (514 aa)
WOR4Wor4p. (401 aa)
SCH9Serine/threonine-protein kinase SCH9; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway (By similarity). Plays a role in filamentous growth and virulence. Prevents hypha formation specifically under hypoxia at high CO(2) levels. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen- limited environments and has been reported in clinical specimens. (787 aa)
CAP1AP-1-like transcription factor CAP1; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Involved in the oxidative stress response in via multiple pathways, including the cellular antioxidant defense system, carbohydrate metabolism and energy metabolism, protein degradation, ATP-dependent RNA helicase, and resistance pathways. The ability of the major systemic fungal pathogen of humans to sense and respond to reactive oxygen species, such as H(2)O(2) ge [...] (499 aa)
SFL2Transcription factor SFL2; Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature. Required for human oral epithelium colonization and damage. Promotes filamentous growth in EFG1- and FLO8-dependent manners. Antagonizes functions of SFL1. Belongs to the HSF family. (714 aa)
CDR1Pleiotropic ABC efflux transporter of multiple drugs CDR1; Pleiotropic ABC efflux transporter that confers resistance to numerous chemicals including anisomycin, cycloheximide, fluconazole, miconazole, ketoconazole, itriconazole, nystatin, terbinafine, amorolfine, brefeldin A, amphotericin B, fluphenazine, as well as estrogen. Plays a role in farnesol-induced apoptotic process through glutathione efflux activity. Mediates in-to-out transloaction of membrane phospholipids including aminophospholipids and thus regulates asymmetric distribution of phosphatidylethanolamine. Exhibits nucleo [...] (1501 aa)
WOR2White-opaque regulator 2; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth. (446 aa)
WOR1White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...] (785 aa)
HOG1Mitogen-activated protein kinase HOG1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Regulates stress-induced production and accumulation of glycerol and D-arabitol. HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program. (377 aa)
MET3Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. Belongs to the sulfate adenylyltransferase family. (527 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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