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PHR1 PHR1 CPH1 CPH1 HWP1 HWP1 CDR2 CDR2 ECE1 ECE1 BRG1 BRG1 UME6 UME6 ARO10 ARO10 EFH1 EFH1 SUV3 SUV3 NDH51 NDH51 GAL1 GAL1 GPX2 GPX2 EFG1 EFG1 CZF1 CZF1 CEK1 CEK1 GOA1 GOA1 RBR1 RBR1 WOR3 WOR3 IHD2 IHD2 RBF1 RBF1 SOD6 SOD6 FCR1 FCR1 DLD2 DLD2 NDE1 NDE1 DBP4 DBP4 MAC1 MAC1 CHK1 CHK1 HFL1 HFL1 EXG2 EXG2 CaO19.1691 CaO19.1691 COX4 COX4 CPA1 CPA1 RFX2 RFX2 TRY4 TRY4 HCM1 HCM1 NAD4 NAD4 NAD5 NAD5 NAD4L NAD4L NAD3 NAD3 NAD2 NAD2 NAD1 NAD1 NAD6 NAD6 RAD32 RAD32 OPI1 OPI1 ATP18 ATP18 DPB4 DPB4 AOX2 AOX2 CDR4 CDR4 IFD6 IFD6 CaO19.3062 CaO19.3062 GSC1 GSC1 CaO19.3353 CaO19.3353 RIM2 RIM2 QCR8 QCR8 CaO19.2184 CaO19.2184 ZCF1 ZCF1 ZCF16 ZCF16 CDR11 CDR11 ZCF21 ZCF21 ILV6 ILV6 QCR9 QCR9 ALD6 ALD6 ARO9 ARO9 ZCF5 ZCF5 CaO19.107 CaO19.107 SOD3 SOD3 GRX1 GRX1 INO2 INO2 PDK2 PDK2 XYL2 XYL2 PHR2 PHR2 COX1 COX1 KRE1 KRE1 TUP1 TUP1 INO4 INO4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PHR1pH-responsive protein 1; Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism. (548 aa)
CPH1Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. (656 aa)
HWP1Hyphal wall protein 1; Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence fact [...] (634 aa)
CDR2Multidrug resistance protein CDR2; Multidrug efflux transporter. Confers resistance to azole antifungal agents, to other antifungals (terbinafine, amorolfine) and to a variety of metabolic inhibitors; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1499 aa)
ECE1Extent of cell elongation protein 1; Secreted protein involved in biofilm formation. Further cleaved by KEX2 in 8 similar peptides (ECE1- I to ECE1-VIII). (271 aa)
BRG1Biofilm regulator 1; Transcription factor required for hyphal growth, biofilm formation, and virulence. Promotes formation of both conventional and pheromone-stimulated biofilms. Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner. Involved in the switch between two heritable states, the white and opaque states. These two cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically at low frequency. (422 aa)
UME6Transcriptional regulatory protein UME6; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promo [...] (843 aa)
ARO10Phenylpyruvate decarboxylase. (629 aa)
EFH1Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. (720 aa)
SUV3ATP-dependent RNA helicase SUV3, mitochondrial; Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions (By similarity). Required for embedded hyphal growth, for wild-type respiratory growth, and biofilm development. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen- limited environments and has been reported in clinical specimens. Plays am important role in virulence. (720 aa)
NDH51NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (490 aa)
GAL1Galactokinase. (515 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (163 aa)
EFG1Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] (550 aa)
CZF1Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...] (385 aa)
CEK1Extracellular signal-regulated kinase 1. (421 aa)
GOA1Goa1p. (278 aa)
RBR1Repressed By RIM101 protein 1; Probable cell wall protein required for filamentation at low pH. (111 aa)
WOR3White-opaque regulator 3; Transcription factor that modulates the white-opaque switch. (641 aa)
IHD2Ihd2p. (248 aa)
RBF1Transcription factor RBF1; Transcriptional activator that binds to the RPG box and to telomeres. Involved in the regulation of the transition between yeast and filamentous forms and plays a role in virulence. Induces expression of HWP1, a major hyphal cell protein and virulence factor. Belongs to the RBF1 family. (534 aa)
SOD6Cell surface superoxide dismutase [Cu-Zn] 6; Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. May be involved protection against extracellular stress. (316 aa)
FCR1Fcr1p. (517 aa)
DLD2D-lactate dehydrogenase. (533 aa)
NDE1NADH-ubiquinone reductase (H(+)-translocating). (574 aa)
DBP4ATP-dependent RNA helicase DBP4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (765 aa)
MAC1Metal-binding activator 1; Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth. (431 aa)
CHK1Histidine protein kinase 1; Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan and glucan biosynthesis. Regulates quorum sensing as well as hyphal formation, biofilm formation, chlamidospore formation, and virulence. Plays a prominent role in phagocyte activation. Involved in the covering of the most potent proinflammatory cell wall molecules, the beta-glucans, underneath a dense mannan layer, so that the pathogen becomes partly invisible for immune cells such as phagocytes. (2471 aa)
HFL1DNA polymerase epsilon noncatalytic subunit. (237 aa)
EXG2Glucan 1,3-beta-glucosidase 2; Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. EXG2 is not heavily involved in the exoglucanase function of the adhesion process. (479 aa)
CaO19.1691HIG1 domain-containing protein. (195 aa)
COX4Cytochrome c oxidase subunit IV. (157 aa)
CPA1Carbamoyl-phosphate synthase arginine-specific small chain; Belongs to the CarA family. (430 aa)
RFX2RFX-like DNA-binding protein RFX2; Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1; Belongs to the RFX family. (1111 aa)
TRY4Transcriptional regulator of yeast form adherence 4; Transcription factor required for yeast cell adherence to silicone substrate. (286 aa)
HCM1Hcm1p. (579 aa)
NAD4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (464 aa)
NAD5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (552 aa)
NAD4LNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (84 aa)
NAD3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (129 aa)
NAD2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (475 aa)
NAD1NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (317 aa)
NAD6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (146 aa)
RAD32DNA-directed DNA polymerase eta. (640 aa)
OPI1Transcriptional regulator. (432 aa)
ATP18F1F0 ATP synthase subunit i. (64 aa)
DPB4DNA polymerase epsilon noncatalytic subunit. (261 aa)
AOX2Alternative oxidase. (365 aa)
CDR4Cdr4p; Belongs to the ABC transporter superfamily. (1490 aa)
IFD6Ifd6p. (344 aa)
CaO19.3062Uncharacterized protein. (1179 aa)
GSC11,3-beta-glucan synthase. (1897 aa)
CaO19.3353CIA30 domain-containing protein. (227 aa)
RIM2Rim2p; Belongs to the mitochondrial carrier (TC 2.A.29) family. (399 aa)
QCR8Ubiquinol--cytochrome-c reductase subunit 8. (95 aa)
CaO19.2184FAA_hydrolase domain-containing protein. (292 aa)
ZCF1Zcf1p. (838 aa)
ZCF16Zcf16p. (1078 aa)
CDR11Cdr11p; Belongs to the ABC transporter superfamily. (1512 aa)
ZCF21Zcf21p. (629 aa)
ILV6Acetolactate synthase regulatory subunit. (302 aa)
QCR9Ubiquinol--cytochrome-c reductase subunit 9. (65 aa)
ALD6Ald6p. (541 aa)
ARO9Aromatic-amino-acid:2-oxoglutarate transaminase. (523 aa)
ZCF5Zcf5p. (971 aa)
CaO19.107RNA helicase. (831 aa)
SOD3Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (206 aa)
GRX1Grx1p. (123 aa)
INO2Ino2p. (379 aa)
PDK2Protein-serine/threonine kinase. (511 aa)
XYL2L-iditol 2-dehydrogenase. (360 aa)
PHR2pH-responsive protein 2; Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism (By similarity). (544 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (531 aa)
KRE1Protein KRE1; Involved in cell wall 1,6-beta-glucan assembly possibly by the addition of linear side chains of 1,6-linked Glc units to a highly branched 1,6- and 1,3-linked glucan backbone; Belongs to the KRE1 family. (130 aa)
TUP1Transcriptional repressor TUP1; Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of the response to farnesol. Plays an important role in the regulation of white-opaque switching. (512 aa)
INO4Ino4p. (130 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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