10 items (Candida albicans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Others

textmining

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protein homology

Your Input:
	MLH1	Mismatch repair ATPase. (717 aa)
	MCM6	DNA helicase; Belongs to the MCM family. (880 aa)
	SMC3	Structural maintenance of chromosomes protein. (1237 aa)
	CDC47	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
	MLH3	Mismatch repair protein. (636 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1214 aa)
	SMC6	DNA repair protein. (1128 aa)
	RAD51	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
	SMC5	DNA repair ATPase. (1073 aa)
	MUS81	Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)

Your Current Organism:

Candida albicans

NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC47	MCM6	A0A1D8PIE7	A0A1D8PS48	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
CDC47	MSH6	A0A1D8PIE7	A0A1D8PFM1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.442
CDC47	RAD51	A0A1D8PIE7	Q59UY8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.514
CDC47	SMC3	A0A1D8PIE7	A0A1D8PJK7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Structural maintenance of chromosomes protein.	0.464
CDC47	SMC5	A0A1D8PIE7	Q59UE8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA repair ATPase.	0.555
CDC47	SMC6	A0A1D8PIE7	Q5AGX1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA repair protein.	0.495
MCM6	CDC47	A0A1D8PS48	A0A1D8PIE7	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
MCM6	MLH1	A0A1D8PS48	Q59SL0	DNA helicase; Belongs to the MCM family.	Mismatch repair ATPase.	0.519
MCM6	MSH6	A0A1D8PS48	A0A1D8PFM1	DNA helicase; Belongs to the MCM family.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.839
MCM6	RAD51	A0A1D8PS48	Q59UY8	DNA helicase; Belongs to the MCM family.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.816
MCM6	SMC3	A0A1D8PS48	A0A1D8PJK7	DNA helicase; Belongs to the MCM family.	Structural maintenance of chromosomes protein.	0.571
MCM6	SMC5	A0A1D8PS48	Q59UE8	DNA helicase; Belongs to the MCM family.	DNA repair ATPase.	0.691
MCM6	SMC6	A0A1D8PS48	Q5AGX1	DNA helicase; Belongs to the MCM family.	DNA repair protein.	0.765
MLH1	MCM6	Q59SL0	A0A1D8PS48	Mismatch repair ATPase.	DNA helicase; Belongs to the MCM family.	0.519
MLH1	MLH3	Q59SL0	A0A1D8PFX1	Mismatch repair ATPase.	Mismatch repair protein.	0.997
MLH1	MSH6	Q59SL0	A0A1D8PFM1	Mismatch repair ATPase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.999
MLH1	MUS81	Q59SL0	Q59NG5	Mismatch repair ATPase.	Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.800
MLH1	RAD51	Q59SL0	Q59UY8	Mismatch repair ATPase.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.683
MLH1	SMC3	Q59SL0	A0A1D8PJK7	Mismatch repair ATPase.	Structural maintenance of chromosomes protein.	0.688
MLH1	SMC5	Q59SL0	Q59UE8	Mismatch repair ATPase.	DNA repair ATPase.	0.743