12 items (Candida albicans) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Predicted Interactions

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Your Input:
	URA3	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (270 aa)
	CaO19.1121	Uncharacterized protein. (273 aa)
	CaO19.4230	Proteasome subunit beta; Belongs to the peptidase T1B family. (278 aa)
	ORC4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa)
	CaO19.3166	Dopey_N domain-containing protein. (1669 aa)
	SIR2	NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa)
	CSE4	Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (211 aa)
	HHT21	Histone H3.1/H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
	HHF1	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
	CaO19.951	Uncharacterized protein. (162 aa)
	CaO19.949	Uncharacterized protein. (811 aa)
	HHT3	Histone H3.3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)

Your Current Organism:

Candida albicans

NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSE4	HHF1	Q59LN9	Q59VN4	Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.994
CSE4	ORC4	Q59LN9	A0A1D8PNC0	Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.484
CSE4	SIR2	Q59LN9	O59923	Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).	NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching.	0.749
CSE4	URA3	Q59LN9	P13649	Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family.	0.569
CaO19.1121	CaO19.3166	A0A1D8PNS9	A0A1D8PNB4	Uncharacterized protein.	Dopey_N domain-containing protein.	0.617
CaO19.1121	CaO19.4230	A0A1D8PNS9	A0A1D8PNC8	Uncharacterized protein.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.617
CaO19.1121	CaO19.949	A0A1D8PNS9	Q5A4Z7	Uncharacterized protein.	Uncharacterized protein.	0.868
CaO19.1121	CaO19.951	A0A1D8PNS9	Q5A4Z5	Uncharacterized protein.	Uncharacterized protein.	0.868
CaO19.3166	CaO19.1121	A0A1D8PNB4	A0A1D8PNS9	Dopey_N domain-containing protein.	Uncharacterized protein.	0.617
CaO19.3166	CaO19.4230	A0A1D8PNB4	A0A1D8PNC8	Dopey_N domain-containing protein.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.881
CaO19.3166	CaO19.949	A0A1D8PNB4	Q5A4Z7	Dopey_N domain-containing protein.	Uncharacterized protein.	0.835
CaO19.3166	CaO19.951	A0A1D8PNB4	Q5A4Z5	Dopey_N domain-containing protein.	Uncharacterized protein.	0.835
CaO19.3166	ORC4	A0A1D8PNB4	A0A1D8PNC0	Dopey_N domain-containing protein.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.832
CaO19.4230	CaO19.1121	A0A1D8PNC8	A0A1D8PNS9	Proteasome subunit beta; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.617
CaO19.4230	CaO19.3166	A0A1D8PNC8	A0A1D8PNB4	Proteasome subunit beta; Belongs to the peptidase T1B family.	Dopey_N domain-containing protein.	0.881
CaO19.4230	CaO19.949	A0A1D8PNC8	Q5A4Z7	Proteasome subunit beta; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.835
CaO19.4230	CaO19.951	A0A1D8PNC8	Q5A4Z5	Proteasome subunit beta; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.835
CaO19.4230	ORC4	A0A1D8PNC8	A0A1D8PNC0	Proteasome subunit beta; Belongs to the peptidase T1B family.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.832
CaO19.949	CaO19.1121	Q5A4Z7	A0A1D8PNS9	Uncharacterized protein.	Uncharacterized protein.	0.868
CaO19.949	CaO19.3166	Q5A4Z7	A0A1D8PNB4	Uncharacterized protein.	Dopey_N domain-containing protein.	0.835