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| | SOD6 | Cell surface superoxide dismutase [Cu-Zn] 6; Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. May be involved protection against extracellular stress. (316 aa) |
| | MXR1 | Peptide-methionine-S-sulfoxide reductase. (185 aa) |
| | PGA32 | Probable GPI-anchored adhesin-like protein PGA32; Putative adhesin which is involved in cell adhesion and virulence. (430 aa) |
| | BMT1 | Beta-mannosyltransferase 1; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the first beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan. Plays a key role in reducing host inflammatory response. (684 aa) |
| | TIM13 | Mitochondrial import inner membrane translocase subunit TIM13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates [...] (108 aa) |
| | MGM1 | Dynamin-related GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (897 aa) |
| | IFH1 | Transcriptional regulator IFH1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1. (885 aa) |
| | TOM40 | Tom40p. (390 aa) |
| | EHD3 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (502 aa) |
| | EXG2 | Glucan 1,3-beta-glucosidase 2; Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. EXG2 is not heavily involved in the exoglucanase function of the adhesion process. (479 aa) |
| | SCW4 | Scw4p; Belongs to the glycosyl hydrolase 17 family. (578 aa) |
| | CAP1 | AP-1-like transcription factor CAP1; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Involved in the oxidative stress response in via multiple pathways, including the cellular antioxidant defense system, carbohydrate metabolism and energy metabolism, protein degradation, ATP-dependent RNA helicase, and resistance pathways. The ability of the major systemic fungal pathogen of humans to sense and respond to reactive oxygen species, such as H(2)O(2) ge [...] (499 aa) |
| | PFK1 | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (987 aa) |
| | PGA37 | Predicted GPI-anchored protein 37; Predicted GPI-anchored protein which may have a role during host infection. (208 aa) |
| | COX19 | Cytochrome c oxidase assembly protein COX19; Required for the assembly of mitochondrial cytochrome c oxidase; Belongs to the COX19 family. (132 aa) |
| | CaO19.1485 | 54S ribosomal protein L31, mitochondrial. (113 aa) |
| | PGA57 | Predicted GPI-anchored protein 57; Predicted GPI-anchored protein which may have a role during host infection. (214 aa) |
| | MDH1-1 | Malate dehydrogenase. (332 aa) |
| | ATG9 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (952 aa) |
| | MIR1 | Mir1p; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa) |
| | NAD4 | NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (464 aa) |
| | NAD5 | NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (552 aa) |
| | NAD4L | NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (84 aa) |
| | NAD3 | NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (129 aa) |
| | NAD2 | NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (475 aa) |
| | ATP8 | ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (48 aa) |
| | ATP6 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (246 aa) |
| | ATP9 | ATP synthase subunit 9, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (76 aa) |
| | NAD1 | NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (317 aa) |
| | NAD6 | NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (146 aa) |
| | COX2 | Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (262 aa) |
| | FBA1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa) |
| | CHS2 | Chitin synthase. (1009 aa) |
| | UBP6 | Ubiquitin carboxyl-terminal hydrolase. (478 aa) |
| | CaO19.3353 | CIA30 domain-containing protein. (227 aa) |
| | AOX2 | Alternative oxidase. (365 aa) |
| | SAM35 | SAM complex subunit. (251 aa) |
| | RHO2 | Rho family GTPase. (187 aa) |
| | GCN1 | Gcn1p. (2415 aa) |
| | ECM18 | Alpha/beta hydrolase family protein. (506 aa) |
| | GTT12 | Bifunctional glutathione transferase/peroxidase; Belongs to the GST superfamily. (249 aa) |
| | SKN1 | Skn1p. (737 aa) |
| | OAC1 | Oac1p; Belongs to the mitochondrial carrier (TC 2.A.29) family. (350 aa) |
| | A0A1D8PLE7 | Uncharacterized protein; Belongs to the complex I LYR family. (78 aa) |
| | IMG2 | Mitochondrial 54S ribosomal protein IMG2. (123 aa) |
| | SFC1 | Sfc1p; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa) |
| | CaO19.3998 | Uncharacterized protein. (161 aa) |
| | A0A1D8PP97 | Uncharacterized protein. (81 aa) |
| | YHM1 | Yhm1p; Belongs to the mitochondrial carrier (TC 2.A.29) family. (304 aa) |
| | CaO19.6555 | CHY-type domain-containing protein. (118 aa) |
| | ERV1 | Sulfhydryl oxidase. (182 aa) |
| | CaO19.2414 | Uncharacterized protein. (322 aa) |
| | CIT1 | Citrate synthase; Belongs to the citrate synthase family. (467 aa) |
| | ACO2 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (791 aa) |
| | CaO19.6605 | Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (287 aa) |
| | UBC4 | E2 ubiquitin-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | TRX1 | Thioredoxin; Belongs to the thioredoxin family. (103 aa) |
| | MIA40 | Mitochondrial intermembrane space import and assembly protein 40; Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond [...] (252 aa) |
| | ATG8 | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] (135 aa) |
| | COX1 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (531 aa) |
| | COB | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (387 aa) |
| | LAB5 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (386 aa) |
| | PGK1 | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (417 aa) |
| | GFA1 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). (713 aa) |
| | HXK2 | Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. (484 aa) |
| | PGI1 | Glucose-6-phosphate isomerase. (550 aa) |
| | RHD1 | Beta-mannosyltransferase 2; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan; Belongs to the BMT family. (654 aa) |
| | TIM9 | Mitochondrial import inner membrane translocase subunit TIM9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta- barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. (87 aa) |
| | ICL1 | Isocitrate lyase. (550 aa) |
| | PIR1 | Cell wall mannoprotein PIR1; Component of the outer cell wall layer required for stability of the cell wall and specifically for cell wall rigidity. (385 aa) |
| | PAM18 | Mitochondrial import inner membrane translocase subunit TIM14; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity); Belongs to the TIM14 family. (157 aa) |
| | UBC8 | E2 ubiquitin-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (190 aa) |
| | CaO19.93 | Uncharacterized protein. (151 aa) |
| | DSE1 | Protein DSE1; Involved in cell wall metabolism and required for the separation of the mother and daughter cells. (724 aa) |
| | PRB1 | Prb1p; Belongs to the peptidase S8 family. (465 aa) |
| | ATG13 | Autophagy-related protein 13; Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity). (761 aa) |
| | CYM1 | Mitochondrial presequence protease; ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity); Belongs to the peptidase M16 family. PreP subfamily. (1034 aa) |
| | PGA14 | Hydrophilin PGA14; Hydrophilin which is essential to overcome the simple stress of the desiccation-rehydration process; Belongs to the PGA14 family. (131 aa) |
| | KRE62 | Kre62p. (622 aa) |
| | PRX1 | Thioredoxin peroxidase. (243 aa) |
| | UBC15 | Ubc15p. (175 aa) |
| | MDH1-3 | Malate dehydrogenase. (342 aa) |
| | ATG27 | Autophagy-related protein 27; Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre- autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity); Belongs to the ATG27 family. (252 aa) |
| | PGA31 | Cell wall protein PGA31; Component of the cell wall involved in virulence which plays a role in the relationship between C.albicans and the host (By similarity). Involved in the regulation or assembly of chitin within the cell wall. (293 aa) |
| | RBR2 | Repressed By RIM101 protein 2; Probable cell wall protein which may have esterase activity, with a preference for esters of fatty acids from 4 to 16 carbon atoms. Belongs to the SRP1/TIP1 family. (168 aa) |
| | BMT3 | Beta-mannosyltransferase 3; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the second beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan, and in elongation of beta- mannose chains on the phosphopeptidomannan acid-labile fraction. Belongs to the BMT family. (549 aa) |
| | MGE1 | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (242 aa) |
| | CaO19.2438 | Putative mitochondrial 37S ribosomal protein MRPS12. (180 aa) |
