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LAC1 | Lac1p. (427 aa) | ||||
SIR2 | NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa) | ||||
GCN5 | Histone acetyltransferase. (449 aa) | ||||
RPD3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa) |