STRINGSTRING
RPL10A RPL10A RPP1A RPP1A RAD54 RAD54 LCB2 LCB2 TPD3 TPD3 RFA1 RFA1 ATG3 ATG3 SUI2 SUI2 CaO19.2518 CaO19.2518 RPS24 RPS24 ATG15 ATG15 CaO19.6438 CaO19.6438 MCM2 MCM2 MAD2 MAD2 RAD51 RAD51 CDC46 CDC46 GLC7 GLC7 KCS1 KCS1 CDC28 CDC28 RPS1 RPS1 RPS22B RPS22B ATG8 ATG8 ARP2 ARP2 SMC1 SMC1 MCM6 MCM6 RPP1B RPP1B CYR1 CYR1 POL3 POL3 GCN2 GCN2 A0A1D8PN83 A0A1D8PN83 RAD50 RAD50 SPO11 SPO11 RPS10 RPS10 TOR1 TOR1 MCM3 MCM3 IRR1 IRR1 SEC18 SEC18 A0A1D8PCQ5 A0A1D8PCQ5 APC1 APC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL10A60S ribosomal protein L10a; Belongs to the universal ribosomal protein uL1 family. (217 aa)
RPP1A60S acidic ribosomal protein P1-A; Plays an important role in the elongation step of protein synthesis. (106 aa)
RAD54DNA-dependent ATPase. (848 aa)
LCB2Serine C-palmitoyltransferase. (569 aa)
TPD3Protein phosphatase 2A structural subunit. (643 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
ATG3Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of [...] (333 aa)
SUI2Translation initiation factor eIF2 subunit alpha. (300 aa)
CaO19.2518TPR_REGION domain-containing protein. (293 aa)
RPS2440S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (135 aa)
ATG15Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (597 aa)
CaO19.6438Serine C-palmitoyltransferase. (587 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
MAD2Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
GLC7Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
KCS1Kinase; Belongs to the inositol phosphokinase (IPK) family. (352 aa)
CDC28Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa)
RPS140S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family. (256 aa)
RPS22B40S ribosomal protein S22-B; Belongs to the universal ribosomal protein uS8 family. (130 aa)
ATG8Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] (135 aa)
ARP2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (391 aa)
SMC1Structural maintenance of chromosomes protein. (1240 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
RPP1BRibosomal protein P1B; Belongs to the eukaryotic ribosomal protein P1/P2 family. (108 aa)
CYR1Adenylate cyclase. (1690 aa)
POL3DNA polymerase. (1038 aa)
GCN2Serine/threonine-protein kinase. (1764 aa)
A0A1D8PN83Ribosomal 40S subunit protein S11A; Belongs to the universal ribosomal protein uS17 family. (155 aa)
RAD50MRX complex DNA-binding subunit. (1332 aa)
SPO11Spo11p. (309 aa)
RPS10Ribosomal 40S subunit protein S10A. (118 aa)
TOR1Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2482 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
IRR1Irr1p. (1089 aa)
SEC18AAA family ATPase. (796 aa)
A0A1D8PCQ5Ribosomal 60S subunit protein L26B. (127 aa)
APC1Anaphase promoting complex subunit 1. (1535 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.