Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

Transcription regulator.

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...]

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

White-opaque regulator 3; Transcription factor that modulates the white-opaque switch.

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

Wor4p.

Bromodomain-containing factor 1; Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA- damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).

Cac2p.

Bromodomain-containing factor 1; Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA- damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).

TATA-binding protein-associated factor.

Bromodomain-containing factor 1; Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA- damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).

Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).

Cac2p.

Bromodomain-containing factor 1; Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA- damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).

Cac2p.

4-nitrophenylphosphatase.

Cac2p.

Histone acetyltransferase RTT109; Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. Required for efficient pathogenesis in mice suggesting that efficient DNA repair is required for pathogenesis. Plays an important role in the regulation of white-opaque genotoxin induced-switching; Belongs to the RTT109 family.

Cac2p.

Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family.

Mating-type-like protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating. Belongs to the MATA1 family.

White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...]

Mating-type-like protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating. Belongs to the MATA1 family.

White-opaque regulator 2; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.

Nat4p.

4-nitrophenylphosphatase.

Nat4p.

Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.

Nat4p.

Histone deacetylase.

Nat4p.

Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis; Belongs to the class V-like SAM-binding methyltransferase superfamily.

4-nitrophenylphosphatase.

Cac2p.

4-nitrophenylphosphatase.

Nat4p.

4-nitrophenylphosphatase.

Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.