11 items (Candida albicans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EXO1	Rad2 family nuclease. (699 aa)
	MLH1	Mismatch repair ATPase. (717 aa)
	POL3	DNA polymerase. (1038 aa)
	RAD51	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
	MSH3	DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1037 aa)
	SPO11	Spo11p. (309 aa)
	MSH2	Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa)
	MLH3	Mismatch repair protein. (636 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1214 aa)
	PMS1	ATP-binding mismatch repair protein. (910 aa)
	REC8	Rad21_Rec8_N domain-containing protein. (635 aa)

Your Current Organism:

Candida albicans

NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EXO1	MLH1	A0A1D8PMZ2	Q59SL0	Rad2 family nuclease.	Mismatch repair ATPase.	0.984
EXO1	MLH3	A0A1D8PMZ2	A0A1D8PFX1	Rad2 family nuclease.	Mismatch repair protein.	0.920
EXO1	MSH2	A0A1D8PMZ2	Q5A102	Rad2 family nuclease.	Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR).	0.986
EXO1	MSH3	A0A1D8PMZ2	Q59Y41	Rad2 family nuclease.	DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...]	0.865
EXO1	MSH6	A0A1D8PMZ2	A0A1D8PFM1	Rad2 family nuclease.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.987
EXO1	PMS1	A0A1D8PMZ2	A0A1D8PII6	Rad2 family nuclease.	ATP-binding mismatch repair protein.	0.985
EXO1	POL3	A0A1D8PMZ2	A0A1D8PR64	Rad2 family nuclease.	DNA polymerase.	0.894
EXO1	RAD51	A0A1D8PMZ2	Q59UY8	Rad2 family nuclease.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.991
EXO1	SPO11	A0A1D8PMZ2	A0A1D8PID6	Rad2 family nuclease.	Spo11p.	0.887
MLH1	EXO1	Q59SL0	A0A1D8PMZ2	Mismatch repair ATPase.	Rad2 family nuclease.	0.984
MLH1	MLH3	Q59SL0	A0A1D8PFX1	Mismatch repair ATPase.	Mismatch repair protein.	0.997
MLH1	MSH2	Q59SL0	Q5A102	Mismatch repair ATPase.	Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR).	0.998
MLH1	MSH3	Q59SL0	Q59Y41	Mismatch repair ATPase.	DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...]	0.991
MLH1	MSH6	Q59SL0	A0A1D8PFM1	Mismatch repair ATPase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.999
MLH1	PMS1	Q59SL0	A0A1D8PII6	Mismatch repair ATPase.	ATP-binding mismatch repair protein.	0.999
MLH1	POL3	Q59SL0	A0A1D8PR64	Mismatch repair ATPase.	DNA polymerase.	0.652
MLH1	RAD51	Q59SL0	Q59UY8	Mismatch repair ATPase.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.683
MLH1	SPO11	Q59SL0	A0A1D8PID6	Mismatch repair ATPase.	Spo11p.	0.700
MLH3	EXO1	A0A1D8PFX1	A0A1D8PMZ2	Mismatch repair protein.	Rad2 family nuclease.	0.920
MLH3	MLH1	A0A1D8PFX1	Q59SL0	Mismatch repair protein.	Mismatch repair ATPase.	0.997