STRINGSTRING
NIK1 NIK1 CaO19.2821 CaO19.2821 CEK1 CEK1 CaO19.2915 CaO19.2915 CaO19.7591 CaO19.7591 A0A1D8PQD5 A0A1D8PQD5 ALI1 ALI1 YPT72 YPT72 CaO19.4758 CaO19.4758 HOG1 HOG1 COX4 COX4 YPT7 YPT7 MKC1 MKC1 MCI4 MCI4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NIK1Histidine protein kinase NIK1; Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Required for hyphal formation and virulence. Plays a role in fungicides sensitivity, probably through the positive regulation of the HOG1-signaling pathway. Presumed to mediate phosphotransfer to the HOG1 MAP kinase pathway during oxidative and perhaps osmotic stress. (1081 aa)
CaO19.2821NADH-ubiquinone oxidoreductase; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
CEK1Extracellular signal-regulated kinase 1. (421 aa)
CaO19.2915Apyrase; Belongs to the GDA1/CD39 NTPase family. (695 aa)
CaO19.7591Uncharacterized protein; Belongs to the complex I 75 kDa subunit family. (720 aa)
A0A1D8PQD5Cytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. (83 aa)
ALI1Ali1p; Belongs to the complex I 30 kDa subunit family. (279 aa)
YPT72Rab family GTPase. (217 aa)
CaO19.4758Uncharacterized protein. (247 aa)
HOG1Mitogen-activated protein kinase HOG1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Regulates stress-induced production and accumulation of glycerol and D-arabitol. HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program. (377 aa)
COX4Cytochrome c oxidase subunit IV. (157 aa)
YPT7Ypt7p. (288 aa)
MKC1Mitogen-activated protein kinase MKC1; Serine/threonine protein kinase component of the cell integrity pathway, a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. Participates in cell wall construction, azole resistance, and host interaction. Required for the signaling for invasive filamentous growth and biofilm formation, and plays a crucial role in virulence. (509 aa)
MCI4Mci4p. (139 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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