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CEK1 CEK1 MNN11 MNN11 MNN43 MNN43 ECM33 ECM33 MNS1 MNS1 ALG9 ALG9 DPM1 DPM1 MNN47 MNN47 WBP1 WBP1 SRT1 SRT1 FTR1 FTR1 MNN41 MNN41 GPI19 GPI19 ALG7 ALG7 OST1 OST1 VAN1 VAN1 DPM3 DPM3 CWH41 CWH41 MNN4 MNN4 MNN46 MNN46 DPM2 DPM2 HOC1 HOC1 MNN45 MNN45 PMR1 PMR1 ALG6 ALG6 PMT1 PMT1 ERG11 ERG11 MNT2 MNT2 MNN9 MNN9 MNT3 MNT3 MNT1 MNT1 MNN21 MNN21 ALG2 ALG2 MNT4 MNT4 GPI8 GPI8 ALG1 ALG1 KTR4 KTR4 MNN26 MNN26 ALG11 ALG11 MNN10 MNN10 MNN15 MNN15 CWH8 CWH8 MNN2 MNN2 PMT4 PMT4 RAS1 RAS1 ANP1 ANP1 MNN14 MNN14 DIE2 DIE2 SMP3 SMP3 MCD4 MCD4 VRG4 VRG4 OCH1 OCH1 ROT2 ROT2 PMT6 PMT6 GPI2 GPI2 RFT1 RFT1 ALS1 ALS1 GPI15 GPI15 ALG13 ALG13 PMT5 PMT5 MNN24 MNN24 PMT2 PMT2 BMT1 BMT1 MNN1 MNN1 MNN13 MNN13 ECM331 ECM331 MNN42 MNN42 ALG8 ALG8 RER2 RER2 STT3 STT3 MNN23 MNN23 MNN12 MNN12 GWT1 GWT1 GPI7 GPI7 FBA1 FBA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CEK1Extracellular signal-regulated kinase 1. (421 aa)
MNN11Alpha-1,6-mannosyltransferase. (444 aa)
MNN43Uncharacterized protein. (808 aa)
ECM33Ecm33p. (423 aa)
MNS1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (615 aa)
ALG9Mannosyltransferase. (560 aa)
DPM1Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (239 aa)
MNN47Uncharacterized protein. (706 aa)
WBP1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (437 aa)
SRT1Alkyl transferase; Belongs to the UPP synthase family. (314 aa)
FTR1High-affinity iron permease. (381 aa)
MNN41Uncharacterized protein. (848 aa)
GPI19Phosphatidylinositol N-acetylglucosaminyltransferase. (298 aa)
ALG7UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase. (494 aa)
OST1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (470 aa)
VAN1Van1p. (486 aa)
DPM3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa)
CWH41Cwh41p. (830 aa)
MNN4Mnn4p. (996 aa)
MNN46Uncharacterized protein. (692 aa)
DPM2Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (85 aa)
HOC1Alpha-1,6-mannosyltransferase. (395 aa)
MNN45Mnn4-4p. (872 aa)
PMR1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (917 aa)
ALG6Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. (563 aa)
PMT1Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of the cell wall proteins KRE9, PIR2, RHD3, and ALS1, as well as the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for filamentatio [...] (877 aa)
ERG11Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol. (528 aa)
MNT2Glycolipid 2-alpha-mannosyltransferase 2; Involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D- mannose linkage. Mainly responsible for the addition of the third mannose residue in an O-linked mannose pentamer. Can also substitute for MNT1 by adding the second mannose residue. Important for adherence to host surfaces and for virulence; Belongs to the glycosyltransferase 15 family. (461 aa)
MNN9Mannan polymerase complex subunit MNN9; Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins. (368 aa)
MNT3Probable mannosyltransferase MNT3; Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D- mannose linkage; Belongs to the glycosyltransferase 15 family. (378 aa)
MNT1Glycolipid 2-alpha-mannosyltransferase 1; Involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D- mannose linkage. Mainly responsible for the addition of the second mannose residue in an O-linked mannose pentamer. Can also substitute for MNT2 by adding the third mannose residue. Important for adherence to host surfaces and for virulence. (431 aa)
MNN21Alpha-1,2-mannosyltransferase MNN21; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence. (660 aa)
ALG2Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. (443 aa)
MNT4Putative alpha-1,3-mannosyltransferase MNT4; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Belongs to the MNN1/MNT family. (719 aa)
GPI8GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (383 aa)
ALG1Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity); Belongs to the glycosyltransferase group 1 family. (456 aa)
KTR4Putative mannosyltransferase. (480 aa)
MNN26Alpha-1,2-mannosyltransferase MNN26; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence; Belongs to the MNN1/MNT family. (756 aa)
ALG11GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity); Belongs to the glycosyltransferase group 1 family. (609 aa)
MNN10Alpha-1,6-mannosyltransferase. (335 aa)
MNN15Putative alpha-1,3-mannosyltransferase MNN15; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Belongs to the MNN1/MNT family. (763 aa)
CWH8Cwh8p. (241 aa)
MNN2Alpha-1,2-mannosyltransferase MNN2; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence. Promotes iron uptake and usage along the endocytosis pathway under iron-limiting conditions; Belongs to the MNN1/MNT family. (597 aa)
PMT4Dolichyl-phosphate-mannose--protein mannosyltransferase 4; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of AXL2, responsible for bud site selection, as well as of the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for biofilm formation. [...] (755 aa)
RAS1Ras-like protein 1; Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity). (290 aa)
ANP1Anp1p. (428 aa)
MNN14Putative alpha-1,3-mannosyltransferase MNN14; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Involved in virulence. (685 aa)
DIE2Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol; Belongs to the ALG10 glucosyltransferase family. (450 aa)
SMP3GPI mannosyltransferase 4; Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity). Belongs to the glycosyltransferase 22 family. PIGZ subfamily. (498 aa)
MCD4GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). (971 aa)
VRG4GDP-mannose transporter; Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Involved in hyphal formation. (371 aa)
OCH1Initiation-specific alpha-1,6-mannosyltransferase; Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates (By similarity). Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. N-glycan outer chain epitopes play a crucial role in the host-fungal interaction, virulence, and host immune response such as interleukin synth [...] (385 aa)
ROT2Glucan 1-alpha-glucosidase ROT2; Belongs to the glycosyl hydrolase 31 family. (871 aa)
PMT6Dolichyl-phosphate-mannose--protein mannosyltransferase 6; Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P- mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation and virulence. (832 aa)
GPI2Phosphatidylinositol N-acetylglucosaminyltransferase. (304 aa)
RFT1Oligosaccharide translocation protein RFT1; May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane; Belongs to the RFT1 family. (561 aa)
ALS1Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. (1260 aa)
GPI15Phosphatidylinositol N-acetylglucosaminyltransferase. (205 aa)
ALG13UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity). Belongs to the glycosyltransferase 28 family. (293 aa)
PMT5Dolichyl-phosphate-mannose--protein mannosyltransferase 5; Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P- mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation. (725 aa)
MNN24Alpha-1,2-mannosyltransferase MNN24; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence. (709 aa)
PMT2Dolichyl-phosphate-mannose--protein mannosyltransferase 2; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Essential protein that plays an important role in virulence. Belongs to the glycosyltransferase 39 family. (769 aa)
BMT1Beta-mannosyltransferase 1; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the first beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan. Plays a key role in reducing host inflammatory response. (684 aa)
MNN1Putative alpha-1,3-mannosyltransferase MNN1; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Belongs to the MNN1/MNT family. (800 aa)
MNN13Putative alpha-1,3-mannosyltransferase MNN13; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Belongs to the MNN1/MNT family. (764 aa)
ECM331Cell surface GPI-anchored protein ECM33; Cell surface protein required for proper cell wall integrity and for the correct assembly of the mannoprotein outer layer of the cell wall. (413 aa)
MNN42Uncharacterized protein. (838 aa)
ALG8Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG6/ALG8 glucosyltransferase family. (587 aa)
RER2Alkyl transferase; Belongs to the UPP synthase family. (328 aa)
STT3Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit. (751 aa)
MNN23Alpha-1,2-mannosyltransferase MNN23; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence; Belongs to the MNN1/MNT family. (606 aa)
MNN12Putative alpha-1,3-mannosyltransferase MNN12; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). (828 aa)
GWT1GPI-anchored wall transfer protein 1; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (485 aa)
GPI7GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity). Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily. (885 aa)
FBA1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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