STRINGSTRING
LEU2 LEU2 ACT1 ACT1 TRP1 TRP1 PRE1 PRE1 NAP1 NAP1 BNR1 BNR1 PFY1 PFY1 PRB1 PRB1 GAL1 GAL1 ARC15 ARC15 ARP1 ARP1 HIS3 HIS3 BNI1 BNI1 URA3 URA3 TUB1 TUB1 TPM2 TPM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEU23-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (373 aa)
ACT1Actin. (376 aa)
TRP1N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (226 aa)
PRE1Proteasome subunit beta. (196 aa)
NAP1Nucleosome assembly protein 1; Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis. (435 aa)
BNR1Formin BNR1; May organize microtubules by mediating spindle positioning and movement in the budding process. Required for cytokinesis and the maintenance of polarized hyphal growth; Belongs to the formin homology family. BNI1 subfamily. (1485 aa)
PFY1Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
PRB1Prb1p; Belongs to the peptidase S8 family. (465 aa)
GAL1Galactokinase. (515 aa)
ARC15Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (158 aa)
ARP1Actin-related protein 1; Belongs to the actin family. (414 aa)
HIS3Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (222 aa)
BNI1Formin BNI1; Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Required for the maintenance of polarized hyphal growth. BNI1-mediated actin cables are necessary for positioni [...] (1732 aa)
URA3Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (270 aa)
TUB1Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
TPM2Tropomyosin. (161 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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