Adherence factor; Surface antigen mediating adhesion and aggregation in S.cerevisiae.

Actin-related protein 3; Belongs to the actin family.

Adherence factor; Surface antigen mediating adhesion and aggregation in S.cerevisiae.

Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...]

Adh1p.

Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...]

Adh1p.

Phosphotransferase.

Adh1p.

Hyphal wall protein 1; Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence fact [...]

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

Biofilm regulator 1; Transcription factor required for hyphal growth, biofilm formation, and virulence. Promotes formation of both conventional and pheromone-stimulated biofilms. Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner. Involved in the switch between two heritable states, the white and opaque states. These two cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically at low frequency.

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...]

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

Carbohydrate metabolism regulator TYE7; Key transcriptional regulator of carbohydrate metabolism. Binds the promoter sequences of the glycolytic genes at the CANNTG motif and activates their expression during growth on either fermentable or non-fermentable carbon sources as well as under hypoxic growth conditions. Complete glycolytic activation by GAL4 and TYE7 is required for full virulence. Involved in biofilm formation and negatively regulates hyphal formation under hypoxia. Controls also the expression of the copper transport protein CTR1.

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...]

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Biofilm regulator 1; Transcription factor required for hyphal growth, biofilm formation, and virulence. Promotes formation of both conventional and pheromone-stimulated biofilms. Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner. Involved in the switch between two heritable states, the white and opaque states. These two cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically at low frequency.

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Chitinase 2; Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Extent of cell elongation protein 1; Secreted protein involved in biofilm formation. Further cleaved by KEX2 in 8 similar peptides (ECE1- I to ECE1-VIII).

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Cell surface GPI-anchored protein ECM33; Cell surface protein required for proper cell wall integrity and for the correct assembly of the mannoprotein outer layer of the cell wall.

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...]

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Hypha-specific G1 cyclin-related protein 1; Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throug [...]

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Hyphal wall protein 1; Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence fact [...]

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Hyphally regulated cell wall protein 1; GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through confering resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin- forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections. Belongs to the HYR1/IFF family.

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Multidrug resistance protein 1; Plasma membrane multidrug efflux pump that confers resistance to numerous chemicals including azoles such as fluconazole, voriconazole, and benztriazoles, as well as to benomyl, cycloheximide, methotrexate, 4-nitroquinoline-N-oxide, sulfometuron methyl, cerulenin, and brefeldin A. Belongs to the major facilitator superfamily. CAR1 family.

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Rob1p.

Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.

Candidapepsin-4; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Activates host systemic immunity. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of [...]