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PGA62 PGA62 CUP9 CUP9 SIT1 SIT1 PGA13 PGA13 RIB3 RIB3 CFL1 CFL1 WOR3 WOR3 IHD1 IHD1 PBR1 PBR1 RBT4 RBT4 RFG1 RFG1 PGA11 PGA11 SOD4 SOD4 SSN6 SSN6 WOR4 WOR4 PGA18 PGA18 CCC2 CCC2 RGA2 RGA2 WOR2 WOR2 TEC1 TEC1 RAS2 RAS2 WOR1 WOR1 SFU1 SFU1 CPP1 CPP1 CEK1 CEK1 RBE1 RBE1 YWP1 YWP1 HGT2 HGT2 SHA3 SHA3 SEF1 SEF1 PGA7 PGA7 RBT5 RBT5 ARG4 ARG4 FRE10 FRE10 SUN41 SUN41 YHB1 YHB1 ALS3 ALS3 GPM1 GPM1 HWP1 HWP1 ADF1 ADF1 RPS1 RPS1 HEM3 HEM3 FET99 FET99 FET3 FET3 ZCF20 ZCF20 CFL4 CFL4 CFL5 CFL5 HAP5 HAP5 HAP3 HAP3 TCC1 TCC1 TOS1 TOS1 CaO19.217 CaO19.217 FTR2 FTR2 FTR1 FTR1 ACT1 ACT1 HAP43 HAP43 PDE2 PDE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PGA62Cell wall protein PGA62; Cell wall protein necessary for cell wall integrity. plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation; Belongs to the HWP1 family. (213 aa)
CUP9Cup9p. (344 aa)
SIT1Siderophore transporter. (604 aa)
PGA13GPI-anchored protein 13; Cell wall protein which contributes to cell wall synthesis and is important for acquiring normal surface properties. Required for virulence in a mouse infection model. (456 aa)
RIB33,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (204 aa)
CFL1Ferric/cupric reductase transmembrane component 1; Ferric reductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)- salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity). Involved in maintenance of cell wall integrity (CWI), mitochondrial function, and interaction between the pa [...] (760 aa)
WOR3White-opaque regulator 3; Transcription factor that modulates the white-opaque switch. (641 aa)
IHD1Induced during hyphae development protein 1; GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence. Belongs to the IHD1 family. (392 aa)
PBR1Pbr1p. (175 aa)
RBT4Secreted protein RBT4; Secreted protein that acts as a virulence factor during infections such as in posttraumatic corneal infections. Acts as an important antigen in patients with systemic candidiasis and plays a role in the protection against phagocyte attack. (358 aa)
RFG1Repressor of filamentous growth 1; Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5. (600 aa)
PGA11Predicted GPI-anchored protein 11. (124 aa)
SOD4Cell surface superoxide dismutase [Cu-Zn] 4; Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent. (232 aa)
SSN6Transcription regulator. (1080 aa)
WOR4Wor4p. (401 aa)
PGA18Probable GPI-anchored adhesin-like protein PGA18; Cell wall protein which mediates cell-cell and cell-substrate adhesion. Required for biofilm formation and plays a role in virulence (By similarity); Belongs to the PGA18 family. (753 aa)
CCC2Cu(2+)-transporting P-type ATPase. (1204 aa)
RGA2Rga2p. (1176 aa)
WOR2White-opaque regulator 2; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth. (446 aa)
TEC1Transcription activator TEC1; Transcription factor which regulates genes involved in hyphal development, cell adhesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tub [...] (743 aa)
RAS2Ras2p. (320 aa)
WOR1White-opaque regulator 1; Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2. Phenotypic switching from the white to the opaque phase is a necessary step f [...] (785 aa)
SFU1Suppressor of ferric uptake 1; Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice. (517 aa)
CPP1Dual specificity protein tyrosine phosphatase CCP1; Protein tyrosine phosphatase that acts as a repressor of the yeast-hyphal switch. Plays an important role in virulence. Negatively regulates CST20-HST7-CEK1-CPH1 filamentous growth pathway. Represses hyphal genes such as SAP4, SA5, SAP6, and HYR1, by acting through a CEK1-independent mechanism. (597 aa)
CEK1Extracellular signal-regulated kinase 1. (421 aa)
RBE1Repressed by EFG1 protein 1; Cell wall protein involved in cell wall integrity and which plays a role in virulence. (271 aa)
YWP1Yeast-form wall Protein 1; Cell wall protein which plays an anti-adhesive role and promotes dispersal of yeast forms, which allows the organism to seek new sites for colonization. (533 aa)
HGT2Hgt2p; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (545 aa)
SHA3Putative serine/threonine protein kinase. (595 aa)
SEF1Transcriptional regulatory protein SEF1; Transcription factor which plays an essential role in virulence by activating the transcription of iron uptake genes such as FRE7 in iron-poor environments such as the host bloodstream and internal organs. Promotes commensalism in a mouse model of gastrointestinal infection. (917 aa)
PGA7Predicted GPI-anchored protein 7; GPI-linked hyphal surface heme-binding protein involved in heme-iron utilization. Heme transfer can occur bi-directionally between PGA7 and RBT5, supporting a model in which they cooperate in a heme- acquisition system. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation. (219 aa)
RBT5Repressed by TUP1 protein 5; GPI-linked hyphal surface heme-binding protein involved in heme-iron utilization. Heme transfer can occur bi-directionally between PGA7 and RBT5, supporting a model in which they cooperate in a heme- acquisition system. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation. (241 aa)
ARG4Argininosuccinate lyase. (468 aa)
FRE10Fre10p. (706 aa)
SUN41Secreted beta-glucosidase SUN41; Cell surface beta-glucosidase involved in cytokinesis, cell wall biogenesis, adhesion to host tissue, and biofilm formation; thus playing an important role in the host-pathogen interaction. Has hydrolytic activity on linear (1->3)-beta-D-glucans such as laminaribiose and other laminarioligosaccharides. Belongs to the SUN family. (418 aa)
YHB1Flavohemoprotein; Nitric oxide dioxygenase involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Plays a role in virulence since nitric oxide is generated by macrophages of the host immune system. Belongs to the globin family. (398 aa)
ALS3Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. (1155 aa)
GPM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
HWP1Hyphal wall protein 1; Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence fact [...] (634 aa)
ADF1Adherence factor; Surface antigen mediating adhesion and aggregation in S.cerevisiae. (612 aa)
RPS140S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family. (256 aa)
HEM3Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (340 aa)
FET99Fet99p; Belongs to the multicopper oxidase family. (626 aa)
FET3Ferroxidase; Belongs to the multicopper oxidase family. (624 aa)
ZCF20Zcf20p. (1085 aa)
CFL4Ferric/cupric-chelate reductase. (710 aa)
CFL5Ferric-chelate reductase. (710 aa)
HAP5Hap5p. (348 aa)
HAP3Hap3p. (329 aa)
TCC1Tcc1p. (748 aa)
TOS1Tos1p. (467 aa)
CaO19.217Uncharacterized protein. (379 aa)
FTR2Ftr2p. (382 aa)
FTR1High-affinity iron permease. (381 aa)
ACT1Actin. (376 aa)
HAP43Hap43p. (634 aa)
PDE2Phosphodiesterase. (571 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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