STRINGSTRING
POL32 POL32 UPC2 UPC2 PMS1 PMS1 HOS2 HOS2 CaO19.5651 CaO19.5651 POL3 POL3 URA5 URA5 RPD3 RPD3 GCN5 GCN5 HSP90 HSP90 URA3 URA3 ERG11 ERG11 ERG6 ERG6 SIR2 SIR2 RHO1 RHO1 HHT3 HHT3 RPD31 RPD31 RTT109 RTT109 MSH2 MSH2 HHF1 HHF1 HHT21 HHT21 ERG3 ERG3 MLH1 MLH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POL32DNA polymerase delta subunit. (403 aa)
UPC2Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping. (712 aa)
PMS1ATP-binding mismatch repair protein. (910 aa)
HOS2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (454 aa)
CaO19.5651Histone demethylase. (723 aa)
POL3DNA polymerase. (1038 aa)
URA5Orotate phosphoribosyltransferase. (218 aa)
RPD3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
GCN5Histone acetyltransferase. (449 aa)
HSP90Heat shock protein 90 homolog; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family. (707 aa)
URA3Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (270 aa)
ERG11Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol. (528 aa)
ERG6Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (376 aa)
SIR2NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching. (519 aa)
RHO1GTP-binding protein RHO1. (198 aa)
HHT3Histone H3.3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
RPD31Histone deacetylase. (577 aa)
RTT109Histone acetyltransferase RTT109; Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. Required for efficient pathogenesis in mice suggesting that efficient DNA repair is required for pathogenesis. Plays an important role in the regulation of white-opaque genotoxin induced-switching; Belongs to the RTT109 family. (359 aa)
MSH2Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa)
HHF1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (105 aa)
HHT21Histone H3.1/H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
ERG3C-5 sterol desaturase; Belongs to the sterol desaturase family. (386 aa)
MLH1Mismatch repair ATPase. (717 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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