STRINGSTRING
MEC1 MEC1 NTG1 NTG1 APN2 APN2 MLH3 MLH3 RAD23 RAD23 RAD50 RAD50 DDC1 DDC1 RAD53 RAD53 UNG1 UNG1 APN1 APN1 RAD2 RAD2 EXO1 EXO1 TFB3 TFB3 DUN1 DUN1 DNA2 DNA2 RAD3 RAD3 OGG1 OGG1 YKU80 YKU80 CDC28 CDC28 LIG4 LIG4 RAD14 RAD14 RAD52 RAD52 MUS81 MUS81 MEC3 MEC3 MLH1 MLH1 RAD51 RAD51 RFA2 RFA2 SGS1 SGS1 RAD10 RAD10 KIN28 KIN28 RFA1 RFA1 RAD54 RAD54 POL30 POL30
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEC1Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2325 aa)
NTG1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (320 aa)
APN2DNA-(Apurinic or apyrimidinic site) lyase. (451 aa)
MLH3Mismatch repair protein. (636 aa)
RAD23Rad23p. (416 aa)
RAD50MRX complex DNA-binding subunit. (1332 aa)
DDC1DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (488 aa)
RAD53Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa)
UNG1Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (355 aa)
APN1DNA-(Apurinic or apyrimidinic site) lyase. (364 aa)
RAD2SsDNA endodeoxyribonuclease. (990 aa)
EXO1Rad2 family nuclease. (699 aa)
TFB3TFIIH/NER complex subunit. (360 aa)
DUN1Serine/threonine protein kinase. (530 aa)
DNA2Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa)
RAD3TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit. (765 aa)
OGG18-oxoguanine glycosylase. (353 aa)
YKU80ATP-dependent DNA helicase. (609 aa)
CDC28Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa)
LIG4DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae. (928 aa)
RAD14DNA repair protein RAD14; Involved in DNA excision repair; Belongs to the XPA family. (396 aa)
RAD52Recombinase. (564 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (614 aa)
MEC3Checkpoint protein; Belongs to the HUS1 family. (319 aa)
MLH1Mismatch repair ATPase. (717 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
RFA2Rfa2p. (272 aa)
SGS1ATP-dependent DNA helicase. (1189 aa)
RAD10Rad10p. (338 aa)
KIN28TFIIH complex serine/threonine-protein kinase subunit; Belongs to the protein kinase superfamily. (343 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
RAD54DNA-dependent ATPase. (848 aa)
POL30Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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