Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...]

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

Transcriptional regulator NRG1; Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament- specific gene expression in r [...]

Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.

Transcription regulator.

Cell wall integrity transcriptional regulator CAS5; Transcription factor involved in the cell wall damage response. Acts with ADA2 to promote cell wall integrity. Required for expression of numerous cell wall biosynthesis inhibitor caspofungin- responsive genes. Plays a key role in adherence, hyphal development, and virulence.

SBF complex DNA-binding subunit.

Serine/threonine-protein kinase.

G2/mitotic-specific cyclin CLB2; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54.

Serine/threonine-protein kinase.

G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.

Serine/threonine-protein kinase.

Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...]

Serine/threonine-protein kinase.

Hypha-specific G1 cyclin-related protein 1; Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throug [...]

Serine/threonine-protein kinase.

SBF complex DNA-binding subunit.

Serine/threonine-protein kinase.

Transcriptional repressor TUP1; Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of the response to farnesol. Plays an important role in the regulation of white-opaque switching.

G2/mitotic-specific cyclin CLB2; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54.

Serine/threonine-protein kinase.

G2/mitotic-specific cyclin CLB2; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54.

G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.

G2/mitotic-specific cyclin CLB2; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54.

SBF complex DNA-binding subunit.

G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.

Serine/threonine-protein kinase.

G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.

G2/mitotic-specific cyclin CLB2; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54.

G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.

Hypha-specific G1 cyclin-related protein 1; Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throug [...]

G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.

Cyclin.

G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.

SBF complex DNA-binding subunit.

Transcription factor CPH2; Transcription factor that positively controls filamentous growth, virulence, and invasiveness. Binds directly to the two SRE-1- like elements upstream of TEC1 and thus regulates positively expression of this important hyphal growth regulator. Functions independently of known signaling cascades involving EFG1. Regulates also gene expression during intestinal colonization but is not involved in host cell adhesion.

Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...]

Transcription factor CPH2; Transcription factor that positively controls filamentous growth, virulence, and invasiveness. Binds directly to the two SRE-1- like elements upstream of TEC1 and thus regulates positively expression of this important hyphal growth regulator. Functions independently of known signaling cascades involving EFG1. Regulates also gene expression during intestinal colonization but is not involved in host cell adhesion.

Transcriptional regulator NRG1; Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament- specific gene expression in r [...]