STRINGSTRING
CDC47 CDC47 CaO19.3601 CaO19.3601 RPT6 RPT6 MCM3 MCM3 RFC1 RFC1 RFC5 RFC5 SEC18 SEC18 DLH1 DLH1 CDC6 CDC6 PXA2 PXA2 CDR4 CDR4 YOR1 YOR1 RPT2 RPT2 CDR11 CDR11 DYN1 DYN1 HST6 HST6 ATP2 ATP2 MDN1 MDN1 YME1 YME1 RPT5 RPT5 ORC4 ORC4 RIX7 RIX7 RFC3 RFC3 CaO19.3949 CaO19.3949 CaO19.3980 CaO19.3980 MDL2 MDL2 SNQ2 SNQ2 RFC2 RFC2 YCF1 YCF1 PEX1 PEX1 RRM3 RRM3 PXA1 PXA1 ADP1 ADP1 CaO19.702 CaO19.702 CaO19.6382 CaO19.6382 ELF1 ELF1 HSP104 HSP104 YTA6 YTA6 RFC4 RFC4 CEF3 CEF3 CDR2 CDR2 CDC46 CDC46 CAF16 CAF16 ATM1 ATM1 PIF1 PIF1 RAD51 RAD51 CDC48 CDC48 CaO19.6973 CaO19.6973 PEX6 PEX6 CaO19.4362 CaO19.4362 PR26 PR26 RVB1 RVB1 CaO19.3120 CaO19.3120 CaO19.458 CaO19.458 RPT1 RPT1 KRE30 KRE30 CaO19.6432 CaO19.6432 NAM7 NAM7 PIM1 PIM1 RPT4 RPT4 MLT1 MLT1 CTF18 CTF18 MDL1 MDL1 CaO19.6199 CaO19.6199 GCN20 GCN20 CaO19.2057 CaO19.2057 VPS4 VPS4 RVB2 RVB2 RLI1 RLI1 TFP1 TFP1 AFG3 AFG3 MODF MODF CDR1 CDR1 CaO19.5865 CaO19.5865 HSP78 HSP78 ROA1 ROA1 ORC1 ORC1 CaO19.3019 CaO19.3019
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
CaO19.3601AAA domain-containing protein. (547 aa)
RPT6Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (401 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
RFC1Replication factor C subunit 1. (888 aa)
RFC5Replication factor C subunit 5. (362 aa)
SEC18AAA family ATPase. (796 aa)
DLH1Recombinase; Belongs to the RecA family. (324 aa)
CDC6Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa)
PXA2ATP-binding cassette long-chain fatty acid transporter. (667 aa)
CDR4Cdr4p; Belongs to the ABC transporter superfamily. (1490 aa)
YOR1ATP-binding cassette transporter. (1488 aa)
RPT2Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (441 aa)
CDR11Cdr11p; Belongs to the ABC transporter superfamily. (1512 aa)
DYN1Dynein heavy chain. (4161 aa)
HST6ATP-binding cassette alpha-factor transporter. (1323 aa)
ATP2ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (504 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5035 aa)
YME1I-AAA protease; Belongs to the AAA ATPase family. (687 aa)
RPT5Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (430 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa)
RIX7Putative AAA family ATPase. (827 aa)
RFC3Replication factor C subunit 3. (347 aa)
CaO19.3949Bromo domain-containing protein. (1314 aa)
CaO19.3980Putative RNA helicase. (1929 aa)
MDL2Mdl2p. (783 aa)
SNQ2ATP-binding cassette transporter; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1495 aa)
RFC2Replication factor C subunit 2. (363 aa)
YCF1ATP-binding cassette glutathione S-conjugate transporter. (1579 aa)
PEX1AAA family ATPase peroxin 1. (1090 aa)
RRM3ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (618 aa)
PXA1ATP-binding cassette long-chain fatty acid transporter. (765 aa)
ADP1Putative ATP-dependent permease. (1038 aa)
CaO19.702C2H2-type domain-containing protein. (1105 aa)
CaO19.6382ATP-binding cassette bilirubin transporter. (1490 aa)
ELF1Elf1p. (1195 aa)
HSP104Chaperone ATPase; Belongs to the ClpA/ClpB family. (899 aa)
YTA6Putative AAA family ATPase; Belongs to the AAA ATPase family. (820 aa)
RFC4Replication factor C subunit 4. (323 aa)
CEF3Elongation factor 3; The main role of EF-3 may be to transduce nucleoside triphosphate energy into mechanical energy for translocation during translation. EF-3 stimulates EF-1-alpha-dependent binding of aminoacyl- tRNA to the ribosome. (1050 aa)
CDR2Multidrug resistance protein CDR2; Multidrug efflux transporter. Confers resistance to azole antifungal agents, to other antifungals (terbinafine, amorolfine) and to a variety of metabolic inhibitors; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1499 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
CAF16Putative ATP-binding cassette family ATPase. (320 aa)
ATM1Iron-sulfur clusters transporter ATM1, mitochondrial; Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity). (750 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (906 aa)
RAD51DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (361 aa)
CDC48AAA family ATPase; Belongs to the AAA ATPase family. (826 aa)
CaO19.6973Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. (1258 aa)
PEX6AAA family ATPase peroxin 6. (1157 aa)
CaO19.4362AAA domain-containing protein; Belongs to the AAA ATPase family. (369 aa)
PR26Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (411 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
CaO19.3120ABC transporter domain-containing protein. (579 aa)
CaO19.458Bifunctional AAA family ATPase chaperone/translocase. (444 aa)
RPT1Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (444 aa)
KRE30ATP-binding cassette family ATPase. (609 aa)
CaO19.6432AAA family ATPase. (766 aa)
NAM7ATP-dependent RNA helicase. (1019 aa)
PIM1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1078 aa)
RPT4Proteasome regulatory particle base subunit; Belongs to the AAA ATPase family. (428 aa)
MLT1Multiple drug resistance-associated protein-like transporter 1; Vacuolar multi-drug resistance ABC transporter that may be involved in the transport of bilirubin and glutathione conjugates (By similarity). Plays an important role in virulence. (1606 aa)
CTF18Ctf18p. (853 aa)
MDL1ATP-binding cassette permease. (685 aa)
CaO19.6199ATP-dependent 5'-3' DNA helicase. (719 aa)
GCN20Putative AAA family ATPase. (751 aa)
CaO19.2057M-AAA protease subunit. (846 aa)
VPS4Vacuolar protein sorting-associated protein 4; Pre-vacuolar protein sorting protein involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. Required for extracellular secretion of the secreted aspartyl proteases SAP2, SAP4, SAP5, and SAP6. Its regulation of the pre-vacuolar secretory pathway is critical for virulence. (439 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (498 aa)
RLI1Fe-S cluster-binding ribosome biosynthesis protein. (622 aa)
TFP1V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase (vacuolar ATPase) is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force of 180 mV, inside positive and acidic, in the vacuolar membrane vesicles. Mediates oxidative stress response, filamentous growth, and plays an important role in virulence; Belongs to the ATPase alpha/beta chains family. (617 aa)
AFG3AAA family ATPase. (795 aa)
MODFModfp. (545 aa)
CDR1Pleiotropic ABC efflux transporter of multiple drugs CDR1; Pleiotropic ABC efflux transporter that confers resistance to numerous chemicals including anisomycin, cycloheximide, fluconazole, miconazole, ketoconazole, itriconazole, nystatin, terbinafine, amorolfine, brefeldin A, amphotericin B, fluphenazine, as well as estrogen. Plays a role in farnesol-induced apoptotic process through glutathione efflux activity. Mediates in-to-out transloaction of membrane phospholipids including aminophospholipids and thus regulates asymmetric distribution of phosphatidylethanolamine. Exhibits nucleo [...] (1501 aa)
CaO19.5865DEAH-box RNA-dependent ATPase. (865 aa)
HSP78Heat shock protein 78, mitochondrial; Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP- dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress (By similarity). Belongs to the ClpA/ClpB family. (812 aa)
ROA1Roa1p. (1274 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa)
CaO19.3019SsDNA-dependent ATPase. (678 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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