STRINGSTRING
POL32 POL32 CaO19.2796 CaO19.2796 CDC54 CDC54 DPB4 DPB4 RFC5 RFC5 RFC1 RFC1 MCM3 MCM3 CDC47 CDC47 CaO19.6155 CaO19.6155 POL1 POL1 CaO19.1309 CaO19.1309 PRI2 PRI2 RFC3 RFC3 CaO19.4030 CaO19.4030 DNA2 DNA2 CaO19.5564 CaO19.5564 CaO19.5614 CaO19.5614 RFC2 RFC2 POL3 POL3 MCM6 MCM6 POL2 POL2 DPB2 DPB2 RFC4 RFC4 CDC46 CDC46 RFA2 RFA2 MCM2 MCM2 RAD27 RAD27 RNH1 RNH1 RFA1 RFA1 RNH35 RNH35 HFL1 HFL1 HYS2 HYS2 POL30 POL30 CaO19.4830 CaO19.4830
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POL32DNA polymerase delta subunit. (403 aa)
CaO19.2796DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (664 aa)
CDC54DNA helicase; Belongs to the MCM family. (912 aa)
DPB4DNA polymerase epsilon noncatalytic subunit. (261 aa)
RFC5Replication factor C subunit 5. (362 aa)
RFC1Replication factor C subunit 1. (888 aa)
MCM3DNA helicase; Belongs to the MCM family. (878 aa)
CDC47DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa)
CaO19.6155DNA ligase. (770 aa)
POL1DNA polymerase. (1470 aa)
CaO19.1309Uncharacterized protein. (137 aa)
PRI2DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (543 aa)
RFC3Replication factor C subunit 3. (347 aa)
CaO19.4030DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
DNA2Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease. (1426 aa)
CaO19.5564RNase H domain-containing protein. (232 aa)
CaO19.5614Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (285 aa)
RFC2Replication factor C subunit 2. (363 aa)
POL3DNA polymerase. (1038 aa)
MCM6DNA helicase; Belongs to the MCM family. (880 aa)
POL2DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2211 aa)
DPB2DNA polymerase epsilon noncatalytic subunit. (708 aa)
RFC4Replication factor C subunit 4. (323 aa)
CDC46DNA helicase; Belongs to the MCM family. (728 aa)
RFA2Rfa2p. (272 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
RAD27Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (372 aa)
RNH1Rnh1p. (233 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
RNH35Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (431 aa)
HFL1DNA polymerase epsilon noncatalytic subunit. (237 aa)
HYS2DNA-directed DNA polymerase delta subunit. (474 aa)
POL30Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
CaO19.4830Uncharacterized protein. (110 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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