STRINGSTRING
POL32 POL32 MSH6 MSH6 MLH3 MLH3 RFC5 RFC5 RFC1 RFC1 PMS1 PMS1 CaO19.6155 CaO19.6155 EXO1 EXO1 RFC3 RFC3 RFC2 RFC2 POL3 POL3 RFC4 RFC4 MLH1 MLH1 MSH3 MSH3 RFA2 RFA2 MSH2 MSH2 RFA1 RFA1 HYS2 HYS2 POL30 POL30 CaO19.5970 CaO19.5970 CaO19.4830 CaO19.4830
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POL32DNA polymerase delta subunit. (403 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1214 aa)
MLH3Mismatch repair protein. (636 aa)
RFC5Replication factor C subunit 5. (362 aa)
RFC1Replication factor C subunit 1. (888 aa)
PMS1ATP-binding mismatch repair protein. (910 aa)
CaO19.6155DNA ligase. (770 aa)
EXO1Rad2 family nuclease. (699 aa)
RFC3Replication factor C subunit 3. (347 aa)
RFC2Replication factor C subunit 2. (363 aa)
POL3DNA polymerase. (1038 aa)
RFC4Replication factor C subunit 4. (323 aa)
MLH1Mismatch repair ATPase. (717 aa)
MSH3DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1037 aa)
RFA2Rfa2p. (272 aa)
MSH2Mismatch repair ATPase; Component of the post-replicative DNA mismatch repair system (MMR). (873 aa)
RFA1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
HYS2DNA-directed DNA polymerase delta subunit. (474 aa)
POL30Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
CaO19.5970DNA helicase. (862 aa)
CaO19.4830Uncharacterized protein. (110 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.