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| | BFA1 | Bfa1p. (428 aa) |
| | APC1 | Anaphase promoting complex subunit 1. (1535 aa) |
| | ESP1 | Separase. (1598 aa) |
| | SWI4 | SBF complex DNA-binding subunit. (1019 aa) |
| | TEM1 | Ras family GTPase. (200 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa) |
| | PHO85 | Cyclin-dependent serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (332 aa) |
| | CaO19.5056 | Anaphase promoting complex subunit. (479 aa) |
| | PCL2 | Cyclin. (254 aa) |
| | SWI6 | Transcriptional regulator. (729 aa) |
| | CaO19.667 | Uncharacterized protein. (726 aa) |
| | GIN1 | Chromatin-modulating protein. (1234 aa) |
| | CDC6 | Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa) |
| | CDC54 | DNA helicase; Belongs to the MCM family. (912 aa) |
| | IRR1 | Irr1p. (1089 aa) |
| | BUB2 | Bub2p. (314 aa) |
| | CAK1 | Cyclin-dependent protein kinase-activating kinase. (339 aa) |
| | CDC15 | Serine/threonine protein kinase. (1126 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | LTE1 | Mitotic regulator. (1651 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | YCS4 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1172 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1171 aa) |
| | CDC47 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa) |
| | MIH1 | Putative tyrosine protein phosphatase. (894 aa) |
| | PPH21 | Serine/threonine-protein phosphatase. (360 aa) |
| | YCG1 | Condensin subunit. (1259 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1237 aa) |
| | HRT1 | SCF ubiquitin ligase complex subunit. (123 aa) |
| | DDC1 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (488 aa) |
| | MBP1 | Transcription factor. (852 aa) |
| | RAD53 | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa) |
| | CaO19.366 | DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (336 aa) |
| | BUB1 | Protein kinase. (900 aa) |
| | CaO19.6861 | Anaphase promoting complex subunit 5. (798 aa) |
| | CaO19.1792 | Anaphase promoting complex subunit. (785 aa) |
| | BRN1 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (744 aa) |
| | CaO19.3080 | Sister chromatid cohesion protein. (1046 aa) |
| | CaO19.5692 | Anaphase promoting complex subunit 4. (532 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa) |
| | RAD9 | Chromatin-binding protein. (1174 aa) |
| | PCL1 | Pcl1p. (373 aa) |
| | GRR1 | SCF ubiquitin ligase complex subunit. (780 aa) |
| | GRF10 | Grf10p. (685 aa) |
| | DUN1 | Serine/threonine protein kinase. (530 aa) |
| | CDC20 | Ubiquitin-protein transferase activating protein. (634 aa) |
| | FAR1 | Cyclin-dependent protein serine/threonine kinase inhibiting protein. (768 aa) |
| | YOX1 | Yox1p. (335 aa) |
| | PHO81 | Pho81p. (1330 aa) |
| | CDC27 | Anaphase promoting complex subunit. (875 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | SMC1 | Structural maintenance of chromosomes protein. (1240 aa) |
| | CEK2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa) |
| | CDC45 | DNA replication initiation factor. (579 aa) |
| | MPS1 | Serine/threonine/tyrosine protein kinase. (690 aa) |
| | MCD1 | Kleisin alpha. (564 aa) |
| | CaO19.7644 | Anaphase promoting complex subunit 11. (133 aa) |
| | TUP1 | Transcriptional repressor TUP1; Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of the response to farnesol. Plays an important role in the regulation of white-opaque switching. (512 aa) |
| | CDC28 | Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa) |
| | DBF2 | Cell cycle protein kinase DBF2; Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Required for proper nuclear segregation, mitotic spindle organization, actomyosin ring contraction, primary septum assembly, and normal hyphal morphogenesis. (710 aa) |
| | CKS1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (102 aa) |
| | MEC1 | Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2325 aa) |
| | CDC14 | Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa) |
| | CDC46 | DNA helicase; Belongs to the MCM family. (728 aa) |
| | MEC3 | Checkpoint protein; Belongs to the HUS1 family. (319 aa) |
| | MAD1 | Spindle assembly checkpoint component MAD1; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. (696 aa) |
| | BUB3 | Bub3p. (373 aa) |
| | CaO19.2369 | Origin recognition complex subunit 5. (496 aa) |
| | ORC3 | Origin recognition complex subunit 3. (682 aa) |
| | RFX1 | Transcriptional regulator RFX1; Transcription factor involved in DNA damage responses, morphogenesis, and virulence. (851 aa) |
| | MAD2 | Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa) |
| | GIN4 | Serine/threonine-protein kinase GIN4; Serine/threonine-protein kinase which regulates the localization and the function of the septins during mitosis. Involved in the formation of the septin ring but not the basal septin band. Phosphorylates septins CDC11 and SEP7. Required for the transition from pseudohyphae to hyphae. Acts upstream of IRS4 and INP51 in regulating cell wall integrity responses. Involved in propolis-induced cell death. (1349 aa) |
| | SKP1 | SCF ubiquitin ligase subunit; Belongs to the SKP1 family. (164 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | CLB4 | G2/mitotic-specific cyclin-4; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. (486 aa) |
| | CEK1 | Extracellular signal-regulated kinase 1. (421 aa) |
| | CLN3 | G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics. (465 aa) |
| | CDC23 | Anaphase promoting complex subunit. (582 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1368 aa) |
| | DBF4 | Protein serine/threonine kinase activating protein. (506 aa) |
| | CaO19.5358 | Origin recognition complex subunit 2. (688 aa) |
| | CaO19.3301 | Ubiquitin-binding SDF ubiquitin ligase complex subunit. (735 aa) |
| | CaO19.3289 | Origin recognition complex subunit 6. (363 aa) |
| | CDC4 | SCF ubiquitin ligase complex subunit. (768 aa) |
| | CDC5 | Serine/threonine-protein kinase. (653 aa) |
| | MOB1 | Mob1p. (273 aa) |
| | CDH1 | Cdh1p. (597 aa) |
| | CaO19.6821 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (807 aa) |
| | TPD3 | Protein phosphatase 2A structural subunit. (643 aa) |
| | SSN6 | Transcription regulator. (1080 aa) |
| | CaO19.2728 | Uncharacterized protein. (589 aa) |
| | MCM1 | Transcription factor of morphogenesis MCM1; Transcription factor that is recruited by AHR1 to the promoters of genes involved in biofilm formation, which include several key adhesion genes. Plays an important role in cell adhesion, hyphal growth and virulence. Implicated in the regulation of opaque-phase- specific gene expression. (262 aa) |
| | HSL1 | Serine/threonine-protein kinase HSL1; Protein kinase involved in determination of morphology during the cell cycle of both yeast-form and hyphal cells via regulation of SWE1 and CDC28. Regulates pseudohypha formation, but is not required for septin ring organization or septum formation. Plays an essential role in virulence in a mouse model; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. (1462 aa) |
| | CDC53 | Cullin; Belongs to the cullin family. (752 aa) |
| | CDC55 | Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (519 aa) |
| | CLB2 | G2/mitotic-specific cyclin CLB2; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. Also involved in the phosphorylation of CDC6 and CDC54. (492 aa) |
| | SWE1 | Mitosis inhibitor protein kinase SWE1; Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-18'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Plays an important role in filamentous growth. (1178 aa) |
| | DAM1 | DASH complex subunit DAM1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (277 aa) |
