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| | APC1 | Anaphase promoting complex subunit 1. (1535 aa) |
| | ESP1 | Separase. (1598 aa) |
| | SWI4 | SBF complex DNA-binding subunit. (1019 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (805 aa) |
| | CaO19.3049 | Putative serine/threonine protein kinase. (469 aa) |
| | REC8 | Rad21_Rec8_N domain-containing protein. (635 aa) |
| | CaO19.5056 | Anaphase promoting complex subunit. (479 aa) |
| | SWI6 | Transcriptional regulator. (729 aa) |
| | MSN4 | Stress-responsive transcriptional activator. (757 aa) |
| | CDC6 | Cell division control protein; Belongs to the CDC6/cdc18 family. (481 aa) |
| | DLH1 | Recombinase; Belongs to the RecA family. (324 aa) |
| | CDC54 | DNA helicase; Belongs to the MCM family. (912 aa) |
| | IRR1 | Irr1p. (1089 aa) |
| | HGT7 | Hgt7p; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (546 aa) |
| | HGT8 | Hgt8p; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa) |
| | SPR3 | Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (491 aa) |
| | CDC15 | Serine/threonine protein kinase. (1126 aa) |
| | CDC7 | Serine/threonine protein kinase. (656 aa) |
| | TPK2 | cAMP-dependent protein kinase catalytic subunit; Belongs to the protein kinase superfamily. (413 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (878 aa) |
| | TOR1 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2482 aa) |
| | CaO19.1874 | Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa) |
| | SPO11 | Spo11p. (309 aa) |
| | CDC47 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (781 aa) |
| | PPH21 | Serine/threonine-protein phosphatase. (360 aa) |
| | GPA2 | Guanine nucleotide-binding protein subunit alpha. (503 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1237 aa) |
| | DDC1 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (488 aa) |
| | RAD53 | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (699 aa) |
| | CaO19.5954 | WD_REPEATS_REGION domain-containing protein. (510 aa) |
| | CaO19.366 | DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (336 aa) |
| | UME7 | DNA-binding transcriptional regulator. (458 aa) |
| | BUB1 | Protein kinase. (900 aa) |
| | CaO19.6861 | Anaphase promoting complex subunit 5. (798 aa) |
| | CaO19.1792 | Anaphase promoting complex subunit. (785 aa) |
| | CaO19.5692 | Anaphase promoting complex subunit 4. (532 aa) |
| | GPR1 | Gpr1p. (823 aa) |
| | SNF1 | Non-specific serine/threonine protein kinase. (618 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (564 aa) |
| | RAD9 | Chromatin-binding protein. (1174 aa) |
| | CDC20 | Ubiquitin-protein transferase activating protein. (634 aa) |
| | SAL6 | Serine/threonine-protein phosphatase. (571 aa) |
| | HGT12 | Hgt12p; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (526 aa) |
| | RIM15 | Protein kinase. (1923 aa) |
| | CYR1 | Adenylate cyclase. (1690 aa) |
| | CDC27 | Anaphase promoting complex subunit. (875 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (880 aa) |
| | SMC1 | Structural maintenance of chromosomes protein. (1240 aa) |
| | CDC45 | DNA replication initiation factor. (579 aa) |
| | CaO19.7568 | Uncharacterized protein. (281 aa) |
| | CaO19.7644 | Anaphase promoting complex subunit 11. (133 aa) |
| | CDC28 | Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...] (317 aa) |
| | MEC1 | Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2325 aa) |
| | UME6 | Transcriptional regulatory protein UME6; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promo [...] (843 aa) |
| | GLC7 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | CDC14 | Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...] (542 aa) |
| | EFH1 | Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. (720 aa) |
| | CDC46 | DNA helicase; Belongs to the MCM family. (728 aa) |
| | MEC3 | Checkpoint protein; Belongs to the HUS1 family. (319 aa) |
| | MAD1 | Spindle assembly checkpoint component MAD1; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. (696 aa) |
| | RTS1 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (850 aa) |
| | CaO19.2369 | Origin recognition complex subunit 5. (496 aa) |
| | ORC3 | Origin recognition complex subunit 3. (682 aa) |
| | PPZ1 | Serine/threonine-protein phosphatase. (482 aa) |
| | IME2 | Protein kinase. (520 aa) |
| | MAD2 | Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family. (214 aa) |
| | RME1 | Rme1p. (507 aa) |
| | EFG1 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] (550 aa) |
| | RAS1 | Ras-like protein 1; Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity). (290 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | CLB4 | G2/mitotic-specific cyclin-4; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1. (486 aa) |
| | CLN3 | G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics. (465 aa) |
| | CDC23 | Anaphase promoting complex subunit. (582 aa) |
| | DBF4 | Protein serine/threonine kinase activating protein. (506 aa) |
| | CaO19.5358 | Origin recognition complex subunit 2. (688 aa) |
| | RON1 | NDT80 domain-containing protein. (490 aa) |
| | CaO19.3306 | HORMA domain-containing protein. (607 aa) |
| | CaO19.3289 | Origin recognition complex subunit 6. (363 aa) |
| | CDC5 | Serine/threonine-protein kinase. (653 aa) |
| | NDT80 | Transcription factor. (504 aa) |
| | HGT6 | Hexose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa) |
| | CaO19.6821 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (807 aa) |
| | TPD3 | Protein phosphatase 2A structural subunit. (643 aa) |
| | CaO19.2728 | Uncharacterized protein. (589 aa) |
| | HGT4 | Glucose sensor; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (748 aa) |
| | RAS2 | Ras2p. (320 aa) |
| | TPK1 | Tpk1p; Belongs to the protein kinase superfamily. (405 aa) |
| | SWE1 | Mitosis inhibitor protein kinase SWE1; Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-18'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Plays an important role in filamentous growth. (1178 aa) |
| | MTLA1 | Mating-type-like protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating. Belongs to the MATA1 family. (210 aa) |
