STRINGSTRING
CaO19.4534 CaO19.4534 CaO19.2933 CaO19.2933 MNS1 MNS1 SSH1 SSH1 IRE1 IRE1 DOA1 DOA1 ERO1 ERO1 WBP1 WBP1 KAR2 KAR2 RAD23 RAD23 CaO19.1564 CaO19.1564 LHS1 LHS1 CaO19.880 CaO19.880 JEM1 JEM1 CaO19.1392 CaO19.1392 A0A1D8PIL6 A0A1D8PIL6 CaO19.1761 CaO19.1761 CaO19.2516 CaO19.2516 CaO19.1638 CaO19.1638 HRT1 HRT1 KRE5 KRE5 OST1 OST1 CaO19.7347 CaO19.7347 A0A1D8PKK1 A0A1D8PKK1 CaO19.7426 CaO19.7426 CaO19.5300 CaO19.5300 CWH41 CWH41 CaO19.4247 CaO19.4247 CaO19.3920 CaO19.3920 CaO19.1191 CaO19.1191 CaO19.3438 CaO19.3438 SEC12 SEC12 GCN2 GCN2 CaO19.5175 CaO19.5175 PDI1 PDI1 HLJ1 HLJ1 CaO19.3286 CaO19.3286 A0A1D8PRY9 A0A1D8PRY9 SHP1 SHP1 SEC63 SEC63 YDJ1 YDJ1 CaO19.719 CaO19.719 EMP46 EMP46 CaO19.7329 CaO19.7329 UBC4 UBC4 CaO19.7672 CaO19.7672 SSA1 SSA1 SSA2 SSA2 HSP90 HSP90 SNL1 SNL1 FES1 FES1 CUE1 CUE1 PNG1 PNG1 CaO19.6864 CaO19.6864 SAR1 SAR1 SKP1 SKP1 CDC48 CDC48 CaO19.5833 CaO19.5833 CaO19.3135 CaO19.3135 CaO19.2200 CaO19.2200 CaO19.6408 CaO19.6408 SIL1 SIL1 SSB1 SSB1 SEC23 SEC23 ROT2 ROT2 CaO19.954 CaO19.954 CaO19.5345 CaO19.5345 NPL4 NPL4 PGA63 PGA63 SUI2 SUI2 YOS9 YOS9 SEC13 SEC13 CaO19.6558 CaO19.6558 CaO19.3060 CaO19.3060 SEC62 SEC62 CDC53 CDC53 CaO19.3994 CaO19.3994 STT3 STT3 CaO19.5965 CaO19.5965 SEC24 SEC24 MSI3 MSI3 SEC61 SEC61
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CaO19.4534UBX domain-containing protein. (509 aa)
CaO19.2933Ubiquitin-specific protease. (333 aa)
MNS1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (615 aa)
SSH1Ssh1p; Belongs to the SecY/SEC61-alpha family. (499 aa)
IRE1Bifunctional endoribonuclease/protein kinase. (1223 aa)
DOA1Doa1p. (761 aa)
ERO1ER oxidoreductin. (580 aa)
WBP1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (437 aa)
KAR2Hsp70 family ATPase; Belongs to the heat shock protein 70 family. (687 aa)
RAD23Rad23p. (416 aa)
CaO19.1564Bap31 domain-containing protein. (189 aa)
LHS1Hsp70 family chaperone. (932 aa)
CaO19.880Uncharacterized protein. (1011 aa)
JEM1Jem1p. (636 aa)
CaO19.1392Protein disulfide isomerase. (737 aa)
A0A1D8PIL6Uncharacterized protein. (60 aa)
CaO19.1761Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (171 aa)
CaO19.2516Thioredoxin domain-containing protein. (238 aa)
CaO19.1638Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (861 aa)
HRT1SCF ubiquitin ligase complex subunit. (123 aa)
KRE5Kre5p. (1447 aa)
OST1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (470 aa)
CaO19.7347E2 ubiquitin-conjugating protein. (243 aa)
A0A1D8PKK1Translocon subunit. (68 aa)
CaO19.7426Dolichyl-diphosphooligosaccharide--protein glycotransferase. (340 aa)
CaO19.5300Calnexin. (581 aa)
CWH41Cwh41p. (830 aa)
CaO19.4247Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (315 aa)
CaO19.3920Protein disulfide isomerase. (299 aa)
CaO19.1191Ubiquitin ligase complex subunit. (806 aa)
CaO19.3438Uncharacterized protein. (384 aa)
SEC12Sec12p. (841 aa)
GCN2Serine/threonine-protein kinase. (1764 aa)
CaO19.5175E3 ubiquitin-protein ligase. (1139 aa)
PDI1Protein disulfide isomerase. (559 aa)
HLJ1Type I HSP40 co-chaperone. (331 aa)
CaO19.3286Uncharacterized protein. (427 aa)
A0A1D8PRY9Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (95 aa)
SHP1Protein phosphatase regulator. (371 aa)
SEC63Protein-transporting protein. (673 aa)
YDJ1Type I HSP40 co-chaperone. (393 aa)
CaO19.719E3 ubiquitin-protein ligase. (633 aa)
EMP46Emp46p. (465 aa)
CaO19.7329E2 ubiquitin-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
UBC4E2 ubiquitin-conjugating protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
CaO19.7672Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (331 aa)
SSA1Heat shock protein SSA1; May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. (656 aa)
SSA2Heat shock protein SSA2; May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. (645 aa)
HSP90Heat shock protein 90 homolog; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family. (707 aa)
SNL1Snl1p. (199 aa)
FES1Hsp70 nucleotide exchange factor FES1; Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity). Belongs to the FES1 family. (284 aa)
CUE1Coupling of ubiquitin conjugation to ER degradation protein 1; Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of mem [...] (189 aa)
PNG1Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins [...] (395 aa)
CaO19.6864U-box domain-containing protein. (235 aa)
SAR1Small COPII coat GTPase SAR1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated trans [...] (190 aa)
SKP1SCF ubiquitin ligase subunit; Belongs to the SKP1 family. (164 aa)
CDC48AAA family ATPase; Belongs to the AAA ATPase family. (826 aa)
CaO19.5833Polyubiquitin-binding protein. (363 aa)
CaO19.3135UBX domain-containing protein. (593 aa)
CaO19.2200L-type lectin-like domain-containing protein. (436 aa)
CaO19.6408Uncharacterized protein. (539 aa)
SIL1Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity). (414 aa)
SSB1Hsp70 family ATPase; Belongs to the heat shock protein 70 family. (613 aa)
SEC23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (762 aa)
ROT2Glucan 1-alpha-glucosidase ROT2; Belongs to the glycosyl hydrolase 31 family. (871 aa)
CaO19.954Uncharacterized protein. (439 aa)
CaO19.5345Uncharacterized protein. (339 aa)
NPL4Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (598 aa)
PGA63Protein transport protein SEC31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1265 aa)
SUI2Translation initiation factor eIF2 subunit alpha. (300 aa)
YOS9Protein OS-9 homolog; Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity). (258 aa)
SEC13Protein transport protein SEC13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...] (298 aa)
CaO19.6558Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (815 aa)
CaO19.3060Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (275 aa)
SEC62Translocation protein SEC62; Required for preprotein translocation. (293 aa)
CDC53Cullin; Belongs to the cullin family. (752 aa)
CaO19.3994Dolichyl-diphosphooligosaccharide--protein glycotransferase. (396 aa)
STT3Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit. (751 aa)
CaO19.5965Ubiquitin-ubiquitin ligase. (1075 aa)
SEC24Protein transport protein SEC24; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (928 aa)
MSI3Heat shock protein homolog SSE1. (701 aa)
SEC61Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). (479 aa)
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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