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UMAG_04657 UMAG_04657 HHF1 HHF1 FPR4 FPR4 HTZ1 HTZ1 INO80 INO80 SWC4 SWC4 YAF9 YAF9 UBC2 UBC2 HTA1 HTA1 HTB1 HTB1 NUT2 NUT2 SET2 SET2 CLF1 CLF1 HHT2 HHT2 EAF3 EAF3 HHT1 HHT1 RVB2 RVB2 SWC5 SWC5 POB3 POB3 HAT2 HAT2 BRE1 BRE1 ESA1 ESA1 SWR1 SWR1 SPT16 SPT16 ARP4 ARP4 RVB1 RVB1 PKAR PKAR CYP6 CYP6 UMAG_00101 UMAG_00101 UMAG_01200 UMAG_01200 UMAG_01030 UMAG_01030 UMAG_01027 UMAG_01027 UMAG_00353 UMAG_00353 UMAG_00754 UMAG_00754 UMAG_00750 UMAG_00750 UMAG_00592 UMAG_00592 UMAG_11438 UMAG_11438 UMAG_00399 UMAG_00399 UMAG_06280 UMAG_06280 UMAG_02462 UMAG_02462 KAE1 KAE1 UMAG_12116 UMAG_12116 UMAG_00878 UMAG_00878 UMAG_10066 UMAG_10066 UMAG_10570 UMAG_10570 UMAG_02607 UMAG_02607 UMAG_01694 UMAG_01694 UMAG_05141 UMAG_05141 UMAG_11881 UMAG_11881 UMAG_03227 UMAG_03227 UMAG_10645 UMAG_10645 UMAG_02478 UMAG_02478 UMAG_02102 UMAG_02102 UMAG_02065 UMAG_02065 UMAG_12243 UMAG_12243 UMAG_02053 UMAG_02053 UMAG_02760 UMAG_02760 UMAG_04260 UMAG_04260 UMAG_04206 UMAG_04206 UMAG_02562 UMAG_02562 UMAG_03288 UMAG_03288 UMAG_02958 UMAG_02958 UMAG_03437 UMAG_03437 UMAG_03379 UMAG_03379 UMAG_11010 UMAG_11010 UMAG_03740 UMAG_03740 UMAG_04098 UMAG_04098 UMAG_05403 UMAG_05403 UMAG_11545 UMAG_11545 UMAG_06410 UMAG_06410 UMAG_04381 UMAG_04381 UMAG_04902 UMAG_04902 UMAG_04812 UMAG_04812 UMAG_04761 UMAG_04761 UMAG_05563 UMAG_05563 UMAG_05862 UMAG_05862 UMAG_05410 UMAG_05410 UMAG_05835 UMAG_05835 UMAG_06037 UMAG_06037 UMAG_06210 UMAG_06210 UMAG_11342 UMAG_11342 UMAG_11302 UMAG_11302 UMAG_11301 UMAG_11301 UMAG_05166 UMAG_05166 UMAG_05143 UMAG_05143 UMAG_02445 UMAG_02445 UMAG_02311 UMAG_02311 UMAG_10071 UMAG_10071 UMAG_02948 UMAG_02948 UMAG_02903 UMAG_02903 UMAG_03244 UMAG_03244 UMAG_10447 UMAG_10447 UMAG_03743 UMAG_03743 UMAG_15082 UMAG_15082 UMAG_04059 UMAG_04059 UMAG_11761 UMAG_11761 UMAG_05557 UMAG_05557 UMAG_00575 UMAG_00575 UMAG_10463 UMAG_10463 UMAG_00439 UMAG_00439 UMAG_11308 UMAG_11308 UMAG_11779 UMAG_11779 UMAG_03681 UMAG_03681 UMAG_04013 UMAG_04013 UMAG_04603 UMAG_04603 UMAG_04914 UMAG_04914 UMAG_05626 UMAG_05626 UMAG_10347 UMAG_10347 UMAG_05381 UMAG_05381 UMAG_05262 UMAG_05262 UMAG_10546 UMAG_10546 UMAG_11213 UMAG_11213
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
UMAG_04657Uncharacterized protein. (1943 aa)
HHF1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
FPR4FK506-binding protein 4; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression. (375 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (135 aa)
INO80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1910 aa)
SWC4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (615 aa)
YAF9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (431 aa)
UBC2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
HTA1Histone H2A; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
HTB1Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (142 aa)
NUT2Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (197 aa)
SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (972 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (781 aa)
HHT2Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
EAF3Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (330 aa)
HHT1Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (476 aa)
SWC5SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (354 aa)
POB3FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (558 aa)
HAT2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. (433 aa)
BRE1E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (817 aa)
ESA1Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on [...] (565 aa)
SWR1Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1830 aa)
SPT16FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1032 aa)
ARP4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (534 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (488 aa)
PKARcAMP-dependent protein kinase regulatory subunit. (525 aa)
CYP6Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). (551 aa)
UMAG_00101Chromosome 1, whole genome shotgun sequence. (865 aa)
UMAG_01200Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (738 aa)
UMAG_01030Uncharacterized protein. (606 aa)
UMAG_01027Uncharacterized protein. (734 aa)
UMAG_00353Chromosome 1, whole genome shotgun sequence. (462 aa)
UMAG_00754Chromosome 1, whole genome shotgun sequence. (166 aa)
UMAG_00750Chromosome 1, whole genome shotgun sequence. (613 aa)
UMAG_00592Chromosome 1, whole genome shotgun sequence. (869 aa)
UMAG_11438Chromosome 1, whole genome shotgun sequence. (535 aa)
UMAG_00399Chromosome 1, whole genome shotgun sequence. (943 aa)
UMAG_06280Uncharacterized protein. (1482 aa)
UMAG_02462Zn(2)-C6 fungal-type domain-containing protein. (1561 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (451 aa)
UMAG_12116ARID domain-containing protein. (1332 aa)
UMAG_00878Bromo domain-containing protein. (826 aa)
UMAG_10066Uncharacterized protein. (173 aa)
UMAG_10570Uncharacterized protein. (802 aa)
UMAG_02607Putative chromatin remodeling complex ATPase subunit. (1108 aa)
UMAG_01694Uncharacterized protein. (875 aa)
UMAG_05141UmuC domain-containing protein. (682 aa)
UMAG_11881PHD-type domain-containing protein. (1182 aa)
UMAG_03227Chromosome 8, whole genome shotgun sequence. (273 aa)
UMAG_10645Chromosome 8, whole genome shotgun sequence. (1027 aa)
UMAG_02478Uncharacterized protein. (790 aa)
UMAG_02102Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (727 aa)
UMAG_02065Histone deacetylase. (569 aa)
UMAG_12243Chromosome 10, whole genome shotgun sequence. (1081 aa)
UMAG_02053SCD domain-containing protein. (1414 aa)
UMAG_02760DNA_pol_E_B domain-containing protein. (632 aa)
UMAG_04260Chromosome 12, whole genome shotgun sequence. (575 aa)
UMAG_04206Chromosome 12, whole genome shotgun sequence. (1601 aa)
UMAG_02562Putative proteasome regulatory particle base subunit RPT2; Belongs to the AAA ATPase family. (438 aa)
UMAG_03288Chromosome 8, whole genome shotgun sequence. (249 aa)
UMAG_02958Chromosome 7, whole genome shotgun sequence. (846 aa)
UMAG_03437Chromosome 9, whole genome shotgun sequence. (742 aa)
UMAG_03379Chromosome 8, whole genome shotgun sequence. (716 aa)
UMAG_11010Chromosome 8, whole genome shotgun sequence. (395 aa)
UMAG_03740Chromosome 10, whole genome shotgun sequence. (1250 aa)
UMAG_04098Chromosome 12, whole genome shotgun sequence. (202 aa)
UMAG_05403Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (289 aa)
UMAG_11545YL1_C domain-containing protein. (199 aa)
UMAG_06410Chromosome 23, whole genome shotgun sequence. (796 aa)
UMAG_04381Uncharacterized protein. (2080 aa)
UMAG_04902Chromosome 15, whole genome shotgun sequence; Belongs to the protein kinase superfamily. (379 aa)
UMAG_04812ARID domain-containing protein. (1652 aa)
UMAG_04761Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (257 aa)
UMAG_05563CULLIN_2 domain-containing protein; Belongs to the cullin family. (822 aa)
UMAG_05862Uncharacterized protein. (1094 aa)
UMAG_05410Chromosome 19, whole genome shotgun sequence. (598 aa)
UMAG_05835Structural maintenance of chromosomes protein. (1223 aa)
UMAG_06037Chromosome 21, whole genome shotgun sequence. (653 aa)
UMAG_06210Uncharacterized protein. (826 aa)
UMAG_11342Chromosome 1, whole genome shotgun sequence. (349 aa)
UMAG_11302Chromatin modification-related protein. (538 aa)
UMAG_11301Putative SWI/SNF catalytic subunit. (1506 aa)
UMAG_05166Uncharacterized protein. (1106 aa)
UMAG_05143Putative nucleosome assembly protein I; Belongs to the nucleosome assembly protein (NAP) family. (413 aa)
UMAG_02445Serine/threonine-protein phosphatase. (351 aa)
UMAG_02311PHD domain-containing protein. (1100 aa)
UMAG_10071Uncharacterized protein. (216 aa)
UMAG_02948Chromosome 7, whole genome shotgun sequence. (462 aa)
UMAG_02903Chromosome 7, whole genome shotgun sequence. (249 aa)
UMAG_03244Chromatin modification-related protein. (732 aa)
UMAG_10447Chromosome 9, whole genome shotgun sequence. (182 aa)
UMAG_03743Chromosome 10, whole genome shotgun sequence; Belongs to the actin family. (732 aa)
UMAG_15082Chromosome 10, whole genome shotgun sequence. (1851 aa)
UMAG_04059Uncharacterized protein. (1059 aa)
UMAG_11761KH_dom_type_1 domain-containing protein. (401 aa)
UMAG_05557Uncharacterized protein. (976 aa)
UMAG_00575Chromosome 1, whole genome shotgun sequence. (882 aa)
UMAG_10463Chromosome 1, whole genome shotgun sequence. (623 aa)
UMAG_00439Chromosome 1, whole genome shotgun sequence. (323 aa)
UMAG_11308Histone deacetylase. (585 aa)
UMAG_11779Putative transcriptional regulator. (1721 aa)
UMAG_03681Chromosome 10, whole genome shotgun sequence. (818 aa)
UMAG_04013PAPA-1 domain-containing protein. (545 aa)
UMAG_04603Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (918 aa)
UMAG_04914Chromosome 15, whole genome shotgun sequence. (445 aa)
UMAG_05626Chromosome 16, whole genome shotgun sequence. (292 aa)
UMAG_10347Uncharacterized protein; Belongs to the actin family. (813 aa)
UMAG_05381Chromosome 19, whole genome shotgun sequence. (1346 aa)
UMAG_05262Chromosome 19, whole genome shotgun sequence. (1059 aa)
UMAG_10546Chromosome 19, whole genome shotgun sequence. (184 aa)
UMAG_11213Chromosome 21, whole genome shotgun sequence. (1036 aa)
Your Current Organism:
Ustilago maydis
NCBI taxonomy Id: 237631
Other names: U. maydis 521, Ustilago maydis 521
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