STRINGSTRING
UMAG_06187 UMAG_06187 UMAG_05991 UMAG_05991 UMAG_11213 UMAG_11213 UMAG_05381 UMAG_05381 UMAG_06477 UMAG_06477 UMAG_04878 UMAG_04878 UMAG_12015 UMAG_12015 UMAG_04925 UMAG_04925 UMAG_10709 UMAG_10709 UMAG_12273 UMAG_12273 UMAG_04131 UMAG_04131 UMAG_04151 UMAG_04151 UMAG_10405 UMAG_10405 UMAG_04013 UMAG_04013 UMAG_03863 UMAG_03863 UMAG_11107 UMAG_11107 UMAG_02961 UMAG_02961 UMAG_02543 UMAG_02543 UMAG_02056 UMAG_02056 UMAG_11705 UMAG_11705 UMAG_02343 UMAG_02343 UMAG_10142 UMAG_10142 UMAG_11779 UMAG_11779 UMAG_05184 UMAG_05184 UMAG_15076 UMAG_15076 UMAG_05228 UMAG_05228 UMAG_10620 UMAG_10620 UMAG_12055 UMAG_12055 UMAG_00983 UMAG_00983 UMAG_11308 UMAG_11308 UMAG_00290 UMAG_00290 UMAG_10101 UMAG_10101 UMAG_00439 UMAG_00439 UMAG_11435 UMAG_11435 UMAG_11035 UMAG_11035 UMAG_10925 UMAG_10925 UMAG_05334 UMAG_05334 UMAG_05363 UMAG_05363 UMAG_10751 UMAG_10751 UMAG_04830 UMAG_04830 UMAG_05064 UMAG_05064 UMAG_04384 UMAG_04384 UMAG_04460 UMAG_04460 UMAG_04465 UMAG_04465 UMAG_04551 UMAG_04551 UMAG_04604 UMAG_04604 UMAG_04069 UMAG_04069 UMAG_10482 UMAG_10482 UMAG_15082 UMAG_15082 UMAG_03743 UMAG_03743 UMAG_03793 UMAG_03793 UMAG_03550 UMAG_03550 UMAG_03178 UMAG_03178 UMAG_03244 UMAG_03244 UMAG_03276 UMAG_03276 UMAG_03061 UMAG_03061 UMAG_02605 UMAG_02605 UMAG_10071 UMAG_10071 UMAG_10143 UMAG_10143 UMAG_05127 UMAG_05127 UMAG_05151 UMAG_05151 UMAG_11783 UMAG_11783 UMAG_06296 UMAG_06296 UMAG_01679 UMAG_01679 UMAG_12168 UMAG_12168 UMAG_00971 UMAG_00971 UMAG_11302 UMAG_11302 UMAG_00114 UMAG_00114 UMAG_00183 UMAG_00183 UMAG_00586 UMAG_00586 UMAG_00625 UMAG_00625 UMAG_11828 UMAG_11828 UMAG_00669 UMAG_00669 UMAG_00711 UMAG_00711 UMAG_06210 UMAG_06210 UMAG_06037 UMAG_06037 UMAG_06378 UMAG_06378 UMAG_06387 UMAG_06387 MCM7 MCM7 UMAG_06206 UMAG_06206 UMAG_11227 UMAG_11227 UMAG_06237 UMAG_06237 UMAG_10549 UMAG_10549 UMAG_06029 UMAG_06029 UMAG_05410 UMAG_05410 UMAG_10747 UMAG_10747 UMAG_11192 UMAG_11192 UMAG_05563 UMAG_05563 UMAG_10551 UMAG_10551 UMAG_10936 UMAG_10936 UMAG_04902 UMAG_04902 UMAG_04698 UMAG_04698 UMAG_04722 UMAG_04722 UMAG_04927 UMAG_04927 UMAG_12008 UMAG_12008 UMAG_04833 UMAG_04833 UMAG_04518 UMAG_04518 UMAG_06358 UMAG_06358 UMAG_04168 UMAG_04168 UMAG_10429 UMAG_10429 UMAG_05403 UMAG_05403 UMAG_04098 UMAG_04098 UMAG_04234 UMAG_04234 UMAG_10359 UMAG_10359 UMAG_04047 UMAG_04047 UMAG_05767 UMAG_05767 UMAG_10833 UMAG_10833 UMAG_03680 UMAG_03680 UMAG_04610 UMAG_04610 UMAG_15003 UMAG_15003 UMAG_03304 UMAG_03304 UMAG_02530 UMAG_02530 UMAG_04149 UMAG_04149 UMAG_10433 UMAG_10433 UMAG_12194 UMAG_12194 UMAG_10602 UMAG_10602 UMAG_03079 UMAG_03079 UMAG_03802 UMAG_03802 UMAG_10512 UMAG_10512 UMAG_10599 UMAG_10599 UMAG_02065 UMAG_02065 UMAG_02400 UMAG_02400 UMAG_02102 UMAG_02102 UMAG_03496 UMAG_03496 UMAG_03543 UMAG_03543 UMAG_02324 UMAG_02324 UMAG_02478 UMAG_02478 UMAG_01445 UMAG_01445 UMAG_05100 UMAG_05100 UMAG_11881 UMAG_11881 UMAG_05183 UMAG_05183 UMAG_05213 UMAG_05213 UMAG_02925 UMAG_02925 UMAG_01646 UMAG_01646 UMAG_02619 UMAG_02619 UMAG_10570 UMAG_10570 UMAG_11727 UMAG_11727 UMAG_00922 UMAG_00922 UMAG_12353 UMAG_12353 UMAG_01969 UMAG_01969 UMAG_01093 UMAG_01093 UMAG_00878 UMAG_00878 UMAG_01229 UMAG_01229 UMAG_01293 UMAG_01293 UMAG_02462 UMAG_02462 UMAG_01104 UMAG_01104 UMAG_01191 UMAG_01191 UMAG_10190 UMAG_10190 UMAG_10194 UMAG_10194 UMAG_00144 UMAG_00144 UMAG_00152 UMAG_00152 UMAG_00226 UMAG_00226 UMAG_01529 UMAG_01529 UMAG_11885 UMAG_11885 UMAG_00366 UMAG_00366 UMAG_00399 UMAG_00399 UMAG_00592 UMAG_00592 NOP7 NOP7 UMAG_00289 UMAG_00289 UMAG_00722 UMAG_00722 UMAG_00741 UMAG_00741 UMAG_10100 UMAG_10100 UMAG_00903 UMAG_00903 UMAG_00443 UMAG_00443 UMAG_00991 UMAG_00991 UMAG_11652 UMAG_11652 UMAG_01200 UMAG_01200 UMAG_01338 UMAG_01338 UMAG_12153 UMAG_12153 UMAG_00728 UMAG_00728 SUS1 SUS1 RVB1 RVB1 FEN1 FEN1 EAF1 EAF1 ARP4 ARP4 ERB1 ERB1 SPT16 SPT16 SWR1 SWR1 ESA1 ESA1 HAT2 HAT2 POB3 POB3 SWC5 SWC5 RVB2 RVB2 EAF3 EAF3 TFB5 TFB5 SPB4 SPB4 CCR4 CCR4 SET1 SET1 ASF1 ASF1 MRD1 MRD1 YAF9 YAF9 SWC4 SWC4 HTZ1 HTZ1 IPI3 IPI3 SPT6 SPT6 SPT5 SPT5 TSD2 TSD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UMAG_06187Uncharacterized protein. (1090 aa)
UMAG_05991Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (667 aa)
UMAG_11213Chromosome 21, whole genome shotgun sequence. (1036 aa)
UMAG_05381Chromosome 19, whole genome shotgun sequence. (1346 aa)
UMAG_06477Chromosome 19, whole genome shotgun sequence. (320 aa)
UMAG_04878Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5431 aa)
UMAG_12015Chromosome 16, whole genome shotgun sequence. (331 aa)
UMAG_04925Chromosome 15, whole genome shotgun sequence. (887 aa)
UMAG_10709Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1198 aa)
UMAG_12273G-patch domain-containing protein. (670 aa)
UMAG_04131Chromosome 12, whole genome shotgun sequence. (492 aa)
UMAG_04151Chromosome 12, whole genome shotgun sequence. (850 aa)
UMAG_10405Chromosome 12, whole genome shotgun sequence. (635 aa)
UMAG_04013PAPA-1 domain-containing protein. (545 aa)
UMAG_03863DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1774 aa)
UMAG_11107Chromosome 10, whole genome shotgun sequence. (312 aa)
UMAG_02961Chromosome 7, whole genome shotgun sequence. (887 aa)
UMAG_02543Uncharacterized protein. (869 aa)
UMAG_02056Uncharacterized protein. (253 aa)
UMAG_11705TFIID_20kDa domain-containing protein. (777 aa)
UMAG_02343Uncharacterized protein. (742 aa)
UMAG_10142Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (203 aa)
UMAG_11779Putative transcriptional regulator. (1721 aa)
UMAG_05184PWWP domain-containing protein. (348 aa)
UMAG_15076Uncharacterized protein. (346 aa)
UMAG_05228Uncharacterized protein. (447 aa)
UMAG_10620TAFII55_N domain-containing protein. (621 aa)
UMAG_12055Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (109 aa)
UMAG_00983SANT domain-containing protein. (2193 aa)
UMAG_11308Histone deacetylase. (585 aa)
UMAG_00290Chromosome 1, whole genome shotgun sequence. (1206 aa)
UMAG_10101Chromosome 1, whole genome shotgun sequence. (610 aa)
UMAG_00439Chromosome 1, whole genome shotgun sequence. (323 aa)
UMAG_11435Chromosome 1, whole genome shotgun sequence. (319 aa)
UMAG_11035Bromo domain-containing protein. (1212 aa)
UMAG_10925Chromosome 1, whole genome shotgun sequence. (376 aa)
UMAG_05334Chromosome 19, whole genome shotgun sequence. (170 aa)
UMAG_05363Chromosome 19, whole genome shotgun sequence. (727 aa)
UMAG_10751BSD domain-containing protein. (679 aa)
UMAG_04830Uncharacterized protein. (617 aa)
UMAG_05064DNA helicase; Belongs to the MCM family. (731 aa)
UMAG_04384Uncharacterized protein. (277 aa)
UMAG_04460DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (161 aa)
UMAG_04465Bromo domain-containing protein. (803 aa)
UMAG_04551Uncharacterized protein; Belongs to the cyclin family. (704 aa)
UMAG_04604Uncharacterized protein. (445 aa)
UMAG_04069Putative TFIIH/NER complex ATPase/helicase subunit SSL2. (940 aa)
UMAG_10482Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (116 aa)
UMAG_15082Chromosome 10, whole genome shotgun sequence. (1851 aa)
UMAG_03743Chromosome 10, whole genome shotgun sequence; Belongs to the actin family. (732 aa)
UMAG_03793Chromosome 10, whole genome shotgun sequence. (632 aa)
UMAG_03550Chromosome 9, whole genome shotgun sequence. (329 aa)
UMAG_03178Chromosome 8, whole genome shotgun sequence. (197 aa)
UMAG_03244Chromatin modification-related protein. (732 aa)
UMAG_03276Chromosome 8, whole genome shotgun sequence. (530 aa)
UMAG_03061Chromosome 7, whole genome shotgun sequence. (432 aa)
UMAG_02605PHD domain-containing protein. (1084 aa)
UMAG_10071Uncharacterized protein. (216 aa)
UMAG_10143Putative TATA-binding protein. (239 aa)
UMAG_05127Uncharacterized protein. (466 aa)
UMAG_05151CYCLIN domain-containing protein; Belongs to the cyclin family. (493 aa)
UMAG_11783DUF1767 domain-containing protein. (451 aa)
UMAG_06296RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (491 aa)
UMAG_01679DNA helicase. (906 aa)
UMAG_12168EAF domain-containing protein. (594 aa)
UMAG_00971Matrin-type domain-containing protein. (289 aa)
UMAG_11302Chromatin modification-related protein. (538 aa)
UMAG_00114Chromosome 1, whole genome shotgun sequence. (457 aa)
UMAG_00183Chromosome 1, whole genome shotgun sequence. (572 aa)
UMAG_00586Chromosome 1, whole genome shotgun sequence. (723 aa)
UMAG_00625Chromosome 1, whole genome shotgun sequence. (997 aa)
UMAG_11828Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (442 aa)
UMAG_00669Chromosome 1, whole genome shotgun sequence. (401 aa)
UMAG_00711Chromosome 1, whole genome shotgun sequence. (264 aa)
UMAG_06210Uncharacterized protein. (826 aa)
UMAG_06037Chromosome 21, whole genome shotgun sequence. (653 aa)
UMAG_06378Chromosome 23, whole genome shotgun sequence. (689 aa)
UMAG_06387Chromosome 23, whole genome shotgun sequence. (273 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (846 aa)
UMAG_06206TAF4 domain-containing protein. (452 aa)
UMAG_11227Putative transcription elongation protein. (94 aa)
UMAG_06237Uncharacterized protein. (1441 aa)
UMAG_10549Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (442 aa)
UMAG_06029Chromosome 21, whole genome shotgun sequence. (1227 aa)
UMAG_05410Chromosome 19, whole genome shotgun sequence. (598 aa)
UMAG_10747RNase_PH domain-containing protein. (302 aa)
UMAG_11192TAFII28 domain-containing protein. (460 aa)
UMAG_05563CULLIN_2 domain-containing protein; Belongs to the cullin family. (822 aa)
UMAG_10551General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (516 aa)
UMAG_10936Chromosome 16, whole genome shotgun sequence. (71 aa)
UMAG_04902Chromosome 15, whole genome shotgun sequence; Belongs to the protein kinase superfamily. (379 aa)
UMAG_04698Uncharacterized protein. (296 aa)
UMAG_04722RPOL4c domain-containing protein. (175 aa)
UMAG_04927Chromosome 15, whole genome shotgun sequence. (219 aa)
UMAG_12008Chromosome 15, whole genome shotgun sequence. (3700 aa)
UMAG_04833Putative isovaleryl-CoA dehydrogenase. (424 aa)
UMAG_04518HECT domain-containing protein. (2313 aa)
UMAG_06358Chromosome 23, whole genome shotgun sequence. (867 aa)
UMAG_04168Chromosome 12, whole genome shotgun sequence. (936 aa)
UMAG_10429DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1241 aa)
UMAG_05403Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (289 aa)
UMAG_04098Chromosome 12, whole genome shotgun sequence. (202 aa)
UMAG_04234Chromosome 12, whole genome shotgun sequence. (568 aa)
UMAG_10359DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (133 aa)
UMAG_04047Putative spindle-assembly checkpoint protein. (217 aa)
UMAG_05767Chromosome 16, whole genome shotgun sequence. (1561 aa)
UMAG_10833Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1159 aa)
UMAG_03680Chromosome 10, whole genome shotgun sequence. (433 aa)
UMAG_04610Uncharacterized protein. (703 aa)
UMAG_15003Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (756 aa)
UMAG_03304Chromosome 8, whole genome shotgun sequence. (207 aa)
UMAG_02530SHNi-TPR domain-containing protein. (454 aa)
UMAG_04149Chromosome 12, whole genome shotgun sequence. (228 aa)
UMAG_10433Chromosome 12, whole genome shotgun sequence. (138 aa)
UMAG_12194Uncharacterized protein. (377 aa)
UMAG_10602Uncharacterized protein. (2238 aa)
UMAG_03079Chromosome 7, whole genome shotgun sequence. (1046 aa)
UMAG_03802Chromosome 10, whole genome shotgun sequence. (701 aa)
UMAG_10512Chromosome 10, whole genome shotgun sequence. (208 aa)
UMAG_10599Putative branched-chain alpha-keto acid dehydrogenase subunit e1-beta. (292 aa)
UMAG_02065Histone deacetylase. (569 aa)
UMAG_02400BTP domain-containing protein. (793 aa)
UMAG_02102Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (727 aa)
UMAG_03496Chromosome 9, whole genome shotgun sequence. (793 aa)
UMAG_03543Chromatin modification-related protein. (339 aa)
UMAG_02324RNA_pol_L_2 domain-containing protein. (145 aa)
UMAG_02478Uncharacterized protein. (790 aa)
UMAG_01445DNA helicase; Belongs to the MCM family. (961 aa)
UMAG_05100Uncharacterized protein. (192 aa)
UMAG_11881PHD-type domain-containing protein. (1182 aa)
UMAG_05183Uncharacterized protein. (214 aa)
UMAG_05213Uncharacterized protein. (831 aa)
UMAG_02925Chromosome 7, whole genome shotgun sequence. (769 aa)
UMAG_01646DNA helicase; Belongs to the MCM family. (1020 aa)
UMAG_02619Uncharacterized protein. (1846 aa)
UMAG_10570Uncharacterized protein. (802 aa)
UMAG_11727WD_REPEATS_REGION domain-containing protein. (527 aa)
UMAG_00922Uncharacterized protein. (422 aa)
UMAG_12353Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (87 aa)
UMAG_01969SAGA-associated factor 11. (466 aa)
UMAG_01093Enhancer of polycomb-like protein. (1516 aa)
UMAG_00878Bromo domain-containing protein. (826 aa)
UMAG_01229IPPc domain-containing protein. (1742 aa)
UMAG_01293UmuC domain-containing protein. (763 aa)
UMAG_02462Zn(2)-C6 fungal-type domain-containing protein. (1561 aa)
UMAG_01104Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (256 aa)
UMAG_01191Uncharacterized protein. (630 aa)
UMAG_10190Putative histone acetylase. (744 aa)
UMAG_10194Putative DNA-directed RNA polymerase core subunit RPB10. (71 aa)
UMAG_00144Chromosome 1, whole genome shotgun sequence. (503 aa)
UMAG_00152Chromosome 1, whole genome shotgun sequence. (738 aa)
UMAG_00226Chromosome 1, whole genome shotgun sequence. (317 aa)
UMAG_01529CBS domain-containing protein. (386 aa)
UMAG_11885Uncharacterized protein. (2119 aa)
UMAG_00366DNA helicase; Belongs to the MCM family. (980 aa)
UMAG_00399Chromosome 1, whole genome shotgun sequence. (943 aa)
UMAG_00592Chromosome 1, whole genome shotgun sequence. (869 aa)
NOP7Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (673 aa)
UMAG_00289Chromosome 1, whole genome shotgun sequence. (804 aa)
UMAG_00722Chromosome 1, whole genome shotgun sequence. (665 aa)
UMAG_00741Chromosome 1, whole genome shotgun sequence. (1214 aa)
UMAG_10100Chromosome 1, whole genome shotgun sequence. (215 aa)
UMAG_00903Ubiquitinyl hydrolase 1. (778 aa)
UMAG_00443Chromosome 1, whole genome shotgun sequence. (668 aa)
UMAG_00991Uncharacterized protein. (770 aa)
UMAG_11652Sld5 domain-containing protein. (303 aa)
UMAG_01200Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (738 aa)
UMAG_01338B30.2/SPRY domain-containing protein. (828 aa)
UMAG_12153Chromosome 1, whole genome shotgun sequence. (309 aa)
UMAG_00728Chromosome 1, whole genome shotgun sequence. (706 aa)
SUS1Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (106 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (488 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (374 aa)
EAF1Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (1654 aa)
ARP4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (534 aa)
ERB1Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (932 aa)
SPT16FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1032 aa)
SWR1Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1830 aa)
ESA1Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on [...] (565 aa)
HAT2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. (433 aa)
POB3FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (558 aa)
SWC5SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (354 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (476 aa)
EAF3Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (330 aa)
TFB5General transcription and DNA repair factor IIH subunit TFB5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (65 aa)
SPB4ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (767 aa)
CCR4Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (670 aa)
SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. (1468 aa)
ASF1Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (174 aa)
MRD1Multiple RNA-binding domain-containing protein 1; Involved in pre-rRNA processing; Belongs to the RRM MRD1 family. (858 aa)
YAF9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (431 aa)
SWC4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (615 aa)
HTZ1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (135 aa)
IPI3Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (587 aa)
SPT6Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1723 aa)
SPT5Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (954 aa)
TSD2Protein TSD2; Temperature-sensitive protein required for DNA synthesis. May be a transcription factor that regulates the level or influences the stability of DNA polymerases or auxiliary proteins. (845 aa)
Your Current Organism:
Ustilago maydis
NCBI taxonomy Id: 237631
Other names: U. maydis 521, Ustilago maydis 521
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