(35 nodes) Valine, leucine and isoleucine degradation network (Ustilago maydis)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	UMAG_02783	Uncharacterized protein. (398 aa)
	UMAG_05131	Putative Acetoacetyl-CoA synthetase. (709 aa)
	UMAG_11421	Chromosome 1, whole genome shotgun sequence. (565 aa)
	UMAG_10088	Chromosome 1, whole genome shotgun sequence. (742 aa)
	UMAG_10357	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (425 aa)
	UMAG_10735	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (478 aa)
	UMAG_10402	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (520 aa)
	UMAG_03071	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (577 aa)
	UMAG_06400	Chromosome 23, whole genome shotgun sequence. (462 aa)
	UMAG_11241	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (521 aa)
	UMAG_04833	Putative isovaleryl-CoA dehydrogenase. (424 aa)
	UMAG_03665	Chromosome 10, whole genome shotgun sequence; Belongs to the aldehyde dehydrogenase family. (550 aa)
	UMAG_03523	Chromosome 9, whole genome shotgun sequence; Belongs to the aldehyde dehydrogenase family. (521 aa)
	UMAG_11556	Chromosome 15, whole genome shotgun sequence; Belongs to the enoyl-CoA hydratase/isomerase family. (296 aa)
	UMAG_04382	Putative methylcrotonoyl-CoA carboxylase biotin carboxylase chain. (756 aa)
	UMAG_11932	Chromosome 7, whole genome shotgun sequence. (582 aa)
	UMAG_10596	Putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
	UMAG_02508	Aldehyde dehydrogenase (NADP(+)) ALD4; Belongs to the aldehyde dehydrogenase family. (497 aa)
	UMAG_02667	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (527 aa)
	UMAG_10599	Putative branched-chain alpha-keto acid dehydrogenase subunit e1-beta. (292 aa)
	UMAG_02461	Dihydrolipoyl dehydrogenase. (508 aa)
	UMAG_03571	Chromosome 9, whole genome shotgun sequence; Belongs to the thiolase-like superfamily. Thiolase family. (408 aa)
	UMAG_03298	Chromosome 8, whole genome shotgun sequence; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	UMAG_01935	Putative methylglutaconyl-coa hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (316 aa)
	UMAG_02715	Putative acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
	UMAG_01049	Putative acyl-CoA dehydrogenase, medium-chain specific. (424 aa)
	UMAG_02001	Pyruvate carboxyltransferase domain-containing protein. (353 aa)
	UMAG_01090	Putative acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (418 aa)
	UMAG_01099	Putative short chain 3-hydroxyacyl-CoA dehydrogenase. (344 aa)
	UMAG_00115	Chromosome 1, whole genome shotgun sequence. (408 aa)
	UMAG_01843	Putative acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (414 aa)
	UMAG_00694	Chromosome 1, whole genome shotgun sequence. (403 aa)
	GATA	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (509 aa)
	hcs1	Hydroxymethylglutaryl-CoA synthase; Hydroxymethylglutaryl-CoA synthase involved in the biosynthesis of siderophore ferrichrome A which is contributing to organismal virulence. The first step of ferrichrome A biosynthesis is performed by the HMG-CoA synthase hcs1 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates. The enoyl-CoA isomerase/hydratase fer4 then catalyzes the conversion of hcs1-produced HMG-CoA to methylglutaconyl-CoA. The acyltransferase fer5 then fuses the fer4-generated methylglutaconyl-CoA with sid1-generated hydroxyornit [...] (462 aa)
	fer4	Enoyl-CoA isomerase/hydratase fer4; Enoyl-CoA isomerase/hydratase; part of the gene cluster that mediates the biosynthesis of siderophore ferrichrome A which is contributing to organismal virulence. The first step of ferrichrome A biosynthesis is performed by the HMG-CoA synthase hcs1 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates. The enoyl-CoA isomerase/hydratase fer4 then catalyzes the conversion of hcs1-produced HMG-CoA to methylglutaconyl- CoA. The acyltransferase fer5 then fuses the fer4- generated methylglutaconyl-CoA with si [...] (274 aa)

Your Current Organism:

Ustilago maydis

NCBI taxonomy Id: 237631
Other names: U. maydis 521, Ustilago maydis 521

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA	UMAG_01099	P49604	A0A0D1E6I3	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Putative short chain 3-hydroxyacyl-CoA dehydrogenase.	0.908
GATA	UMAG_02508	P49604	A0A0D1DZV9	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Aldehyde dehydrogenase (NADP(+)) ALD4; Belongs to the aldehyde dehydrogenase family.	0.948
GATA	UMAG_03523	P49604	A0A0D1DVY7	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Chromosome 9, whole genome shotgun sequence; Belongs to the aldehyde dehydrogenase family.	0.948
GATA	UMAG_03665	P49604	A0A0D1DV21	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Chromosome 10, whole genome shotgun sequence; Belongs to the aldehyde dehydrogenase family.	0.949
GATA	UMAG_10402	P49604	A0A0D1CPU6	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.833
GATA	UMAG_10596	P49604	A0A0D1DZI2	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.948
GATA	UMAG_11241	P49604	A0A0D1DMH6	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.953
GATA	UMAG_11421	P49604	A0A0D1CFJ8	4-aminobutyrate aminotransferase; Deaminates gamma-aminobutyric acid (GABA) to succinate- semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Chromosome 1, whole genome shotgun sequence.	0.952
UMAG_00115	UMAG_02001	A0A0D1E6Y6	A0A0D1E597	Chromosome 1, whole genome shotgun sequence.	Pyruvate carboxyltransferase domain-containing protein.	0.547
UMAG_00115	UMAG_02461	A0A0D1E6Y6	A0A0D1E1C8	Chromosome 1, whole genome shotgun sequence.	Dihydrolipoyl dehydrogenase.	0.432
UMAG_00115	UMAG_02783	A0A0D1E6Y6	A0A0D1C7E1	Chromosome 1, whole genome shotgun sequence.	Uncharacterized protein.	0.921
UMAG_00115	UMAG_10357	A0A0D1E6Y6	A0A0D1CHY0	Chromosome 1, whole genome shotgun sequence.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.904
UMAG_00115	UMAG_10402	A0A0D1E6Y6	A0A0D1CPU6	Chromosome 1, whole genome shotgun sequence.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.510
UMAG_00115	UMAG_10599	A0A0D1E6Y6	A0A0D1E0R1	Chromosome 1, whole genome shotgun sequence.	Putative branched-chain alpha-keto acid dehydrogenase subunit e1-beta.	0.956
UMAG_00115	UMAG_10735	A0A0D1E6Y6	A0A0D1CIW9	Chromosome 1, whole genome shotgun sequence.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.958
UMAG_00694	UMAG_01049	A0A0D1EAL0	A0A0D1E583	Chromosome 1, whole genome shotgun sequence.	Putative acyl-CoA dehydrogenase, medium-chain specific.	0.931
UMAG_00694	UMAG_01090	A0A0D1EAL0	A0A0D1E6H3	Chromosome 1, whole genome shotgun sequence.	Putative acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
UMAG_00694	UMAG_01099	A0A0D1EAL0	A0A0D1E6I3	Chromosome 1, whole genome shotgun sequence.	Putative short chain 3-hydroxyacyl-CoA dehydrogenase.	0.632
UMAG_00694	UMAG_01843	A0A0D1EAL0	A0A0D1E8E9	Chromosome 1, whole genome shotgun sequence.	Putative acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.953
UMAG_00694	UMAG_01935	A0A0D1EAL0	A0A0D1E3V6	Chromosome 1, whole genome shotgun sequence.	Putative methylglutaconyl-coa hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.564