node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SET35724.1 | SET39894.1 | SAMN05421676_104155 | SAMN05421676_104295 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent protease ClpP, protease subunit. | 0.951 |
SET35724.1 | SET94037.1 | SAMN05421676_104155 | SAMN05421676_11195 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Protein of unknown function. | 0.947 |
SET35724.1 | SET97889.1 | SAMN05421676_104155 | SAMN05421676_1135 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Protein of unknown function. | 0.947 |
SET35724.1 | clpP | SAMN05421676_104155 | SAMN05421676_101209 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.964 |
SET35724.1 | dnaJ | SAMN05421676_104155 | SAMN05421676_106187 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.923 |
SET35724.1 | dnaK | SAMN05421676_104155 | SAMN05421676_106188 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.955 |
SET35724.1 | groL | SAMN05421676_104155 | SAMN05421676_11614 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.757 |
SET35724.1 | groS | SAMN05421676_104155 | SAMN05421676_11613 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.748 |
SET35724.1 | grpE | SAMN05421676_104155 | SAMN05421676_106189 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.886 |
SET35724.1 | hrcA | SAMN05421676_104155 | SAMN05421676_106190 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.727 |
SET35724.1 | lon | SAMN05421676_104155 | SAMN05421676_1083 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.761 |
SET39894.1 | SET35724.1 | SAMN05421676_104295 | SAMN05421676_104155 | ATP-dependent protease ClpP, protease subunit. | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | 0.951 |
SET39894.1 | SET94037.1 | SAMN05421676_104295 | SAMN05421676_11195 | ATP-dependent protease ClpP, protease subunit. | Protein of unknown function. | 0.590 |
SET39894.1 | SET97889.1 | SAMN05421676_104295 | SAMN05421676_1135 | ATP-dependent protease ClpP, protease subunit. | Protein of unknown function. | 0.590 |
SET39894.1 | SEU00346.1 | SAMN05421676_104295 | SAMN05421676_1146 | ATP-dependent protease ClpP, protease subunit. | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | 0.951 |
SET39894.1 | clpX | SAMN05421676_104295 | SAMN05421676_1085 | ATP-dependent protease ClpP, protease subunit. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.989 |
SET39894.1 | dnaJ | SAMN05421676_104295 | SAMN05421676_106187 | ATP-dependent protease ClpP, protease subunit. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.611 |
SET39894.1 | dnaK | SAMN05421676_104295 | SAMN05421676_106188 | ATP-dependent protease ClpP, protease subunit. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.650 |
SET39894.1 | groL | SAMN05421676_104295 | SAMN05421676_11614 | ATP-dependent protease ClpP, protease subunit. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.687 |
SET39894.1 | groS | SAMN05421676_104295 | SAMN05421676_11613 | ATP-dependent protease ClpP, protease subunit. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.717 |