STRINGSTRING
SET71437.1 SET71437.1 SES66648.1 SES66648.1 SES68098.1 SES68098.1 phnC phnC SES68363.1 SES68363.1 SES69351.1 SES69351.1 clpP clpP uvrA uvrA uvrB uvrB secA secA SES72447.1 SES72447.1 SES72593.1 SES72593.1 SES72853.1 SES72853.1 SES72919.1 SES72919.1 SES74776.1 SES74776.1 rbsA rbsA SES76168.1 SES76168.1 SES76837.1 SES76837.1 metN metN metN-2 metN-2 SES88257.1 SES88257.1 metN-3 metN-3 SES88467.1 SES88467.1 SES88531.1 SES88531.1 SES95463.1 SES95463.1 SES96207.1 SES96207.1 SES96239.1 SES96239.1 SES88799.1 SES88799.1 SES99061.1 SES99061.1 SES99152.1 SES99152.1 SES99404.1 SES99404.1 phnC-2 phnC-2 SEU03421.1 SEU03421.1 SEU01962.1 SEU01962.1 radA radA SEU00346.1 SEU00346.1 SET98884.1 SET98884.1 SET97889.1 SET97889.1 SET95447.1 SET95447.1 SET94037.1 SET94037.1 SET92496.1 SET92496.1 SET92476.1 SET92476.1 SET89974.1 SET89974.1 SET89365.1 SET89365.1 SET88377.1 SET88377.1 dinG dinG ftsA ftsA SET84509.1 SET84509.1 priA priA recG recG hslU hslU smc smc SET85815.1 SET85815.1 clpX clpX SET78603.1 SET78603.1 SET77382.1 SET77382.1 mutS2 mutS2 lon lon xylG xylG SET71106.1 SET71106.1 SET74798.1 SET74798.1 SET73015.1 SET73015.1 SET61835.1 SET61835.1 SET60098.1 SET60098.1 ruvA ruvA ruvB ruvB secF secF SET66524.1 SET66524.1 recD2 recD2 dnaK dnaK SET64774.1 SET64774.1 SET64609.1 SET64609.1 SET64250.1 SET64250.1 SET64207.1 SET64207.1 dnaG dnaG SET63297.1 SET63297.1 pstB pstB SET48490.1 SET48490.1 SET47048.1 SET47048.1 SET50305.1 SET50305.1 SET50001.1 SET50001.1 SET49978.1 SET49978.1 SET49681.1 SET49681.1 SET33507.1 SET33507.1 SET32989.1 SET32989.1 SET32580.1 SET32580.1 SET32461.1 SET32461.1 SET41857.1 SET41857.1 recA recA mutS mutS mutL mutL SET39034.1 SET39034.1 parE parE parC parC SET37340.1 SET37340.1 htpG htpG SET35724.1 SET35724.1 SET35089.1 SET35089.1 SET34442.1 SET34442.1 SET34409.1 SET34409.1 SET34382.1 SET34382.1 SET15541.1 SET15541.1 ychF ychF SET14996.1 SET14996.1 gyrB gyrB gyrA gyrA atpD atpD atpA atpA rho rho SET21467.1 SET21467.1 SET21339.1 SET21339.1 SET20337.1 SET20337.1 SET18720.1 SET18720.1 SET16928.1 SET16928.1 ftsH ftsH tagH tagH SEU08876.1 SEU08876.1 SEU07630.1 SEU07630.1 mfd mfd SEU05828.1 SEU05828.1 SEU05559.1 SEU05559.1 SEU05075.1 SEU05075.1 groL groL groS groS addB addB addA addA SEU03567.1 SEU03567.1 SEU03548.1 SEU03548.1 SET05576.1 SET05576.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SET71437.1ABC-2 type transport system permease protein. (256 aa)
SES66648.1MoxR-like ATPase. (309 aa)
SES68098.1Cu+-exporting ATPase. (794 aa)
phnCPhosphonate transport system ATP-binding protein; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (250 aa)
SES68363.1Phosphonate transport system permease protein. (251 aa)
SES69351.1Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (77 aa)
clpPATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (195 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (956 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (660 aa)
secAPreprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (836 aa)
SES72447.1Ribose transport system ATP-binding protein. (504 aa)
SES72593.1Glucose/mannose transport system permease protein. (310 aa)
SES72853.1Multiple sugar transport system ATP-binding protein; Belongs to the ABC transporter superfamily. (366 aa)
SES72919.1ATP-dependent DNA helicase RecQ. (717 aa)
SES74776.1Ribose transport system ATP-binding protein/rhamnose transport system ATP-binding protein. (518 aa)
rbsARibose transport system ATP-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (498 aa)
SES76168.1Protein of unknown function. (78 aa)
SES76837.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (725 aa)
metND-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (345 aa)
metN-2D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (342 aa)
SES88257.1NgoFVII restriction endonuclease. (385 aa)
metN-3D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (340 aa)
SES88467.1Helicase conserved C-terminal domain-containing protein. (1171 aa)
SES88531.1AAA domain (dynein-related subfamily). (609 aa)
SES95463.1Polar amino acid transport system ATP-binding protein/glutamine transport system ATP-binding protein. (240 aa)
SES96207.1ATP-binding cassette, subfamily B. (578 aa)
SES96239.1ATP-binding cassette, subfamily B. (585 aa)
SES88799.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (517 aa)
SES99061.1ABC-2 type transport system permease protein. (339 aa)
SES99152.1Glycine betaine/proline transport system ATP-binding protein. (398 aa)
SES99404.1EcsC protein family protein. (237 aa)
phnC-2Phosphonate transport system ATP-binding protein; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (263 aa)
SEU03421.1Metal-sulfur cluster biosynthetic enzyme. (103 aa)
SEU01962.1ATP-binding protein involved in chromosome partitioning; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (352 aa)
radADNA repair protein RadA/Sms; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (456 aa)
SEU00346.1ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. (810 aa)
SET98884.1Arsenite-transporting ATPase. (323 aa)
SET97889.1Protein of unknown function. (77 aa)
SET95447.1AAA domain-containing protein. (655 aa)
SET94037.1Protein of unknown function. (77 aa)
SET92496.1ATP-binding cassette, subfamily B/ATP-binding cassette, subfamily B, MsbA. (584 aa)
SET92476.1ATP-binding cassette, subfamily B. (608 aa)
SET89974.1Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. (492 aa)
SET89365.1ATP-dependent DNA helicase RecQ. (514 aa)
SET88377.1TIGR00375 family protein. (390 aa)
dinGATP-dependent DNA helicase DinG; 3'-5' exonuclease. (914 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (431 aa)
SET84509.1Ca2+-transporting ATPase. (886 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (802 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (682 aa)
hslUATP-dependent HslUV protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (464 aa)
smcCondensin subunit Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1188 aa)
SET85815.1PDZ domain-containing protein. (338 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (425 aa)
SET78603.1Cystine transport system ATP-binding protein. (248 aa)
SET77382.1Lon-like ATP-dependent protease. (557 aa)
mutS2DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (784 aa)
lonATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (792 aa)
xylGD-xylose transport system ATP-binding protein; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. (510 aa)
SET71106.1ATP-binding cassette, subfamily B, MsbA. (588 aa)
SET74798.1Cu2+-exporting ATPase. (720 aa)
SET73015.1Cd2+/Zn2+-exporting ATPase. (645 aa)
SET61835.1Helicase conserved C-terminal domain-containing protein. (567 aa)
SET60098.1Hypothetical protein. (557 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (207 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (330 aa)
secFSecD/SecF fusion protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (757 aa)
SET66524.1Putative ATPase. (426 aa)
recD2Exodeoxyribonuclease V alpha subunit; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (777 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (614 aa)
SET64774.1NitT/TauT family transport system substrate-binding protein. (329 aa)
SET64609.1ABC-2 type transport system permease protein. (317 aa)
SET64250.1Hypothetical protein. (236 aa)
SET64207.1Hypothetical protein. (244 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (611 aa)
SET63297.1ATP-dependent RNA helicase CshB. (444 aa)
pstBPhosphate transport system ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (270 aa)
SET48490.1MobA/MobL family protein. (358 aa)
SET47048.1Osmoprotectant transport system ATP-binding protein. (324 aa)
SET50305.15-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB. (531 aa)
SET50001.1Protein of unknown function DUF59. (70 aa)
SET49978.1Hypothetical protein. (162 aa)
SET49681.1Chromosome partitioning protein. (256 aa)
SET33507.1MoxR-like ATPase. (290 aa)
SET32989.1ATP-dependent RNA helicase DeaD; Belongs to the DEAD box helicase family. (498 aa)
SET32580.1Hypothetical protein. (354 aa)
SET32461.1Exonuclease SbcC. (1037 aa)
SET41857.1Flagellum-specific ATP synthase. (439 aa)
recARecombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (349 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (862 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (619 aa)
SET39034.1Stage V sporulation protein K. (308 aa)
parETopoisomerase-4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (649 aa)
parCTopoisomerase-4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. (817 aa)
SET37340.1Heavy-metal-associated domain-containing protein. (73 aa)
htpGMolecular chaperone HtpG; Molecular chaperone. Has ATPase activity. (627 aa)
SET35724.1ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. (710 aa)
SET35089.1Branched-chain amino acid transport system ATP-binding protein. (254 aa)
SET34442.1ATP-dependent helicase/nuclease subunit A; ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1064 aa)
SET34409.1ATP-dependent helicase/nuclease subunit B. (692 aa)
SET34382.1Hypothetical protein. (237 aa)
SET15541.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (455 aa)
ychFHypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
SET14996.1Chromosome partitioning protein. (257 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (640 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (840 aa)
atpDF-type H+-transporting ATPase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (471 aa)
atpAF-type H+-transporting ATPase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (502 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (441 aa)
SET21467.1Polar amino acid transport system ATP-binding protein. (260 aa)
SET21339.1Hypothetical protein. (153 aa)
SET20337.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (779 aa)
SET18720.1Superfamily II DNA or RNA helicase, SNF2 family. (1085 aa)
SET16928.1Type I restriction enzyme, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (981 aa)
ftsHCell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (666 aa)
tagHTeichoic acid transport system ATP-binding protein; Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system. (260 aa)
SEU08876.1Septum site-determining protein MinD. (266 aa)
SEU07630.1Cell division protein FtsA. (718 aa)
mfdTranscription-repair coupling factor (superfamily II helicase); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1182 aa)
SEU05828.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (743 aa)
SEU05559.1MoxR-like ATPase. (318 aa)
SEU05075.1Raffinose/stachyose/melibiose transport system permease protein. (292 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (545 aa)
groSChaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (94 aa)
addBDNA helicase/exodeoxyribonuclease V, subunit B; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 1 subfamily. (1163 aa)
addADNA helicase/exodeoxyribonuclease V, subunit A; ATP-dependent DNA helicase. (1245 aa)
SEU03567.1Phosphonate transport system permease protein. (268 aa)
SEU03548.1Phosphonate transport system permease protein. (276 aa)
SET05576.1Cd2+/Zn2+-exporting ATPase. (677 aa)
Your Current Organism:
Salinibacillus kushneri
NCBI taxonomy Id: 237682
Other names: AS 1.3566, Bacillaceae bacterium 8-2, Bacillaceae bacterium W11-1, JCM 12390, S. kushneri, Salinibacillus kushneri Ren and Zhou 2005, strain 8-2
Server load: low (18%) [HD]