STRINGSTRING
EAQ27969.1 EAQ27969.1 EAQ30645.1 EAQ30645.1 hisC hisC EAQ28865.1 EAQ28865.1 EAQ28629.1 EAQ28629.1 EAQ29351.1 EAQ29351.1 hisD hisD hisG hisG hisI hisI EAQ30294.1 EAQ30294.1 EAQ30497.1 EAQ30497.1 EAQ30644.1 EAQ30644.1 EAQ28628.1 EAQ28628.1 EAQ28377.1 EAQ28377.1 hisB hisB hisH hisH hisA hisA hisF hisF hisE hisE EAQ27841.1 EAQ27841.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EAQ27969.1Xaa-Pro dipeptidase, putative; COG1228 Imidazolonepropionase and related amidohydrolases. (443 aa)
EAQ30645.1Hypothetical protein. (422 aa)
hisCCOG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (378 aa)
EAQ28865.1Hypothetical protein; COG0823 Periplasmic component of the Tol biopolymer transport system. (1096 aa)
EAQ28629.1Hypothetical protein; COG1228 Imidazolonepropionase and related amidohydrolases. (464 aa)
EAQ29351.1COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis. (382 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (229 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (143 aa)
EAQ30294.1COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (470 aa)
EAQ30497.1COG3741 N-formylglutamate amidohydrolase. (338 aa)
EAQ30644.1Hypothetical protein. (328 aa)
EAQ28628.1Hypothetical protein; COG1228 Imidazolonepropionase and related amidohydrolases. (438 aa)
EAQ28377.1COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (256 aa)
hisBCOG0131 Imidazoleglycerol-phosphate dehydratase. (201 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (208 aa)
hisACOG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (245 aa)
hisFImidazoleglycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (266 aa)
hisECOG0140 Phosphoribosyl-ATP pyrophosphohydrolase. (103 aa)
EAQ27841.1COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (343 aa)
Your Current Organism:
Erythrobacter sp. NAP1
NCBI taxonomy Id: 237727
Other names: E. sp. NAP1
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.