(91 nodes) Organic hydroxy compound biosynthetic process network (Coprinopsis cinerea)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CC1G_00827	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (473 aa)
	CC1G_02758	Tyrosinase central domain-containing protein. (346 aa)
	CC1G_02744	Tyrosinase_Cu-bd domain-containing protein. (304 aa)
	CC1G_01691	Sterol 3-beta-glucosyltransferase; Belongs to the glycosyltransferase 28 family. (1217 aa)
	CC1G_01671	C-22 sterol desaturase; Belongs to the cytochrome P450 family. (512 aa)
	CC1G_06570	Phytoceramidase. (270 aa)
	CC1G_00729	Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (278 aa)
	CC1G_00628	Tyrosinase_Cu-bd domain-containing protein. (379 aa)
	CC1G_00576	Cytochrome-b5 reductase. (324 aa)
	CC1G_06001	Inositol-3-phosphate synthase. (555 aa)
	CC1G_06016	Tyrosinase central domain-containing protein. (358 aa)
	CC1G_06017	Tyrosinase_Cu-bd domain-containing protein. (345 aa)
	CC1G_04691	Uncharacterized protein. (616 aa)
	CC1G_11548	Uncharacterized protein. (845 aa)
	CC1G_03317	Thiamine biosynthetic bifunctional enzyme. (523 aa)
	CC1G_02299	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (415 aa)
	CC1G_02350	Amidohydrolase 2; Belongs to the metallo-dependent hydrolases superfamily. (328 aa)
	CC1G_03978	Squalene synthase. (514 aa)
	CC1G_00893	Uncharacterized protein. (481 aa)
	CC1G_00750	Bud site selection protein 16. (361 aa)
	CC1G_05665	Uncharacterized protein. (342 aa)
	CC1G_08364	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (528 aa)
	CC1G_02471	Tyrosinase_Cu-bd domain-containing protein. (380 aa)
	CC1G_07728	Delta-sterol C-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (349 aa)
	CC1G_11060	Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
	CC1G_10006	Uncharacterized protein. (368 aa)
	CC1G_01088	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (464 aa)
	CC1G_05118	Vitamin B6 biosynthesis protein; Belongs to the PdxS/SNZ family. (331 aa)
	CC1G_11764	PriB protein. (626 aa)
	CC1G_03778	DAGKc domain-containing protein. (429 aa)
	CC1G_01585	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	CC1G_10470	Tyrosinase_Cu-bd domain-containing protein. (377 aa)
	CC1G_08048	Tyrosinase_Cu-bd domain-containing protein. (371 aa)
	CC1G_03440	Sterol 3-beta-glucosyltransferase. (1096 aa)
	CC1G_03447	C-3 sterol dehydrogenase. (455 aa)
	CC1G_03354	DJ-1/PfpI family protein. (241 aa)
	CC1G_11702	ThiJ/PfpI domain-containing protein. (231 aa)
	CC1G_02918	Pyridoxamine-phosphate oxidase. (254 aa)
	CC1G_04976	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (313 aa)
	CC1G_05029	Tyrosinase. (638 aa)
	CC1G_10937	C-14 sterol reductase. (443 aa)
	CC1G_06386	Uncharacterized protein. (138 aa)
	CC1G_03987	Squalene epoxidase. (538 aa)
	CC1G_06407	Alpha-methylacyl-CoA racemase. (375 aa)
	CC1G_06409	Zn(2)-C6 fungal-type domain-containing protein. (1108 aa)
	CC1G_12572	Fatty acid hydroxylase; Belongs to the sterol desaturase family. (333 aa)
	CC1G_07100	Uncharacterized protein. (141 aa)
	CC1G_07605	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (558 aa)
	CC1G_08115	Alkyl transferase; Belongs to the UPP synthase family. (261 aa)
	CC1G_04052	Alkyl transferase; Belongs to the UPP synthase family. (261 aa)
	CC1G_00024	Kinase; Belongs to the inositol phosphokinase (IPK) family. (1231 aa)
	CC1G_00037	NADH-cytochrome b5 reductase. (319 aa)
	CC1G_00082	Uncharacterized protein. (360 aa)
	CC1G_00195	Uncharacterized protein. (632 aa)
	CC1G_00260	ThiJ/PfpI. (230 aa)
	CC1G_00287	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (992 aa)
	CC1G_00301	Alcohol dehydrogenase. (492 aa)
	CC1G_01447	Thiamin biosynthesis protein. (556 aa)
	CC1G_08161	Uncharacterized protein; Belongs to the cytochrome P450 family. (506 aa)
	CC1G_08167	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (133 aa)
	CC1G_10336	DJ-1_PfpI domain-containing protein. (197 aa)
	CC1G_07528	Serine C-palmitoyltransferase. (542 aa)
	CC1G_05622	Sterol 24-C-methyltransferase. (263 aa)
	CC1G_05636	Tyrosinase_Cu-bd domain-containing protein. (336 aa)
	CC1G_04738	C-4 methyl sterol oxidase; Belongs to the sterol desaturase family. (330 aa)
	CC1G_04766	DUF2236 domain-containing protein. (438 aa)
	CC1G_05509	C-14 sterol reductase. (498 aa)
	CC1G_06632	Glutamine amidotransferase subunit pdxT. (230 aa)
	CC1G_09662	Uncharacterized protein. (478 aa)
	CC1G_09664	Uncharacterized protein. (478 aa)
	CC1G_09164	DUF2236 domain-containing protein. (418 aa)
	CC1G_09198	Glycosyltransferase family 28 domain-containing protein. (886 aa)
	CC1G_06147	Kinase; Belongs to the inositol phosphokinase (IPK) family. (362 aa)
	CC1G_06149	Sterol 24-C-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (349 aa)
	CC1G_02595	DJ-1/PfpI family protein. (232 aa)
	CC1G_12756	Cytochrome P450; Belongs to the cytochrome P450 family. (305 aa)
	CC1G_05257	Acyl-CoA synthetase. (611 aa)
	CC1G_05275	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1354 aa)
	CC1G_10429	Uncharacterized protein. (473 aa)
	CC1G_10437	Other/FunK1 protein kinase. (717 aa)
	CC1G_14751	Other/FunK1 protein kinase. (830 aa)
	CC1G_03119	Squalene monooxygenase. (485 aa)
	CC1G_09961	C-8 sterol isomerase. (242 aa)
	CC1G_09970	3-keto sterol reductase. (426 aa)
	CC1G_13902	DAGKc domain-containing protein. (484 aa)
	CC1G_14163	Tyrosinase. (615 aa)
	CC1G_14174	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (494 aa)
	CC1G_14103	Neutral ceramidase. (738 aa)
	CC1G_14616	Acetyl-CoA acetyltransferase. (689 aa)
	CC1G_14672	GTP cyclohydrolase I. (284 aa)
	CC1G_15012	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (748 aa)

Your Current Organism:

Coprinopsis cinerea

NCBI taxonomy Id: 240176
Other names: C. cinerea okayama7#130, Coprinopsis cinerea okayama7#130, Coprinus cinereus okayama7#130

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CC1G_00024	CC1G_00287	A8NWG8	A8NXF3	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...]	0.964
CC1G_00024	CC1G_01088	A8NWG8	A8NEH3	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).	0.942
CC1G_00024	CC1G_06001	A8NWG8	A8N4M3	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Inositol-3-phosphate synthase.	0.463
CC1G_00024	CC1G_06147	A8NWG8	A8PAC1	Kinase; Belongs to the inositol phosphokinase (IPK) family.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.845
CC1G_00037	CC1G_00576	A8NWI5	A8N3W4	NADH-cytochrome b5 reductase.	Cytochrome-b5 reductase.	0.900
CC1G_00037	CC1G_08167	A8NWI5	A8NZ62	NADH-cytochrome b5 reductase.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.545
CC1G_00287	CC1G_00024	A8NXF3	A8NWG8	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...]	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.964
CC1G_00287	CC1G_01088	A8NXF3	A8NEH3	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...]	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).	0.948
CC1G_00287	CC1G_06147	A8NXF3	A8PAC1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...]	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.521
CC1G_00301	CC1G_07528	A8NXG9	A8P173	Alcohol dehydrogenase.	Serine C-palmitoyltransferase.	0.458
CC1G_00576	CC1G_00037	A8N3W4	A8NWI5	Cytochrome-b5 reductase.	NADH-cytochrome b5 reductase.	0.900
CC1G_00576	CC1G_08167	A8N3W4	A8NZ62	Cytochrome-b5 reductase.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.690
CC1G_00576	CC1G_15012	A8N3W4	D6RP64	Cytochrome-b5 reductase.	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.466
CC1G_00628	CC1G_02471	A8N3K9	A8NBL1	Tyrosinase_Cu-bd domain-containing protein.	Tyrosinase_Cu-bd domain-containing protein.	0.669
CC1G_00628	CC1G_02744	A8N3K9	A8MZX9	Tyrosinase_Cu-bd domain-containing protein.	Tyrosinase_Cu-bd domain-containing protein.	0.676
CC1G_00628	CC1G_02758	A8N3K9	A8MZV5	Tyrosinase_Cu-bd domain-containing protein.	Tyrosinase central domain-containing protein.	0.670
CC1G_00628	CC1G_05029	A8N3K9	A8NSL2	Tyrosinase_Cu-bd domain-containing protein.	Tyrosinase.	0.672
CC1G_00628	CC1G_05636	A8N3K9	A8P1Q9	Tyrosinase_Cu-bd domain-containing protein.	Tyrosinase_Cu-bd domain-containing protein.	0.667
CC1G_00628	CC1G_06016	A8N3K9	A8N4N8	Tyrosinase_Cu-bd domain-containing protein.	Tyrosinase central domain-containing protein.	0.672
CC1G_00628	CC1G_06017	A8N3K9	A8N4N9	Tyrosinase_Cu-bd domain-containing protein.	Tyrosinase_Cu-bd domain-containing protein.	0.670