(100 nodes) Metabolism of steroids network (Coprinopsis cinerea)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CC1G_07379	Uncharacterized protein. (185 aa)
	CC1G_02028	Uncharacterized protein. (290 aa)
	CC1G_02019	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa)
	CC1G_02008	Uncharacterized protein. (239 aa)
	CC1G_01889	Uncharacterized protein. (706 aa)
	CC1G_04550	Uncharacterized protein. (347 aa)
	CC1G_04609	Farnesyltranstransferase; Belongs to the FPP/GGPP synthase family. (325 aa)
	CC1G_04624	L-carnitine dehydratase/bile acid-inducible protein F. (479 aa)
	CC1G_03704	Oxysterol binding protein. (701 aa)
	CC1G_11292	Isopentenyl-diphosphate Delta-isomerase. (251 aa)
	CC1G_08644	Oxysterol-binding protein family; Belongs to the OSBP family. (474 aa)
	CC1G_04423	Thioesterase II. (292 aa)
	CC1G_10898	3Beta_HSD domain-containing protein. (555 aa)
	CC1G_10895	Uncharacterized protein. (560 aa)
	CC1G_11332	3Beta_HSD domain-containing protein. (511 aa)
	CC1G_11331	Uncharacterized protein. (509 aa)
	CC1G_05514	BHLH domain-containing protein. (1061 aa)
	CC1G_05509	C-14 sterol reductase. (498 aa)
	CC1G_09231	CAIB/BAIF family enzyme. (584 aa)
	CC1G_09213	Transcriptional activator. (162 aa)
	CC1G_04738	C-4 methyl sterol oxidase; Belongs to the sterol desaturase family. (330 aa)
	CC1G_07961	Uncharacterized protein. (602 aa)
	CC1G_07947	Short-chain dehydrogenase/reductase SDR. (258 aa)
	CC1G_08161	Uncharacterized protein; Belongs to the cytochrome P450 family. (506 aa)
	CC1G_01351	Retinal short-chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (372 aa)
	CC1G_00366	Uncharacterized protein. (188 aa)
	CC1G_10036	Uncharacterized protein. (320 aa)
	CC1G_07605	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (558 aa)
	CC1G_12572	Fatty acid hydroxylase; Belongs to the sterol desaturase family. (333 aa)
	CC1G_06409	Zn(2)-C6 fungal-type domain-containing protein. (1108 aa)
	CC1G_06407	Alpha-methylacyl-CoA racemase. (375 aa)
	CC1G_06396	Peroxisomal hydratase-dehydrogenase-epimerase. (599 aa)
	CC1G_06395	Hydroxysteroid dehydrogenase. (303 aa)
	CC1G_06287	SCP2 domain-containing protein. (127 aa)
	CC1G_10937	C-14 sterol reductase. (443 aa)
	CC1G_05046	Ebpl-prov protein. (207 aa)
	CC1G_03025	Multidrug resistance protein 1. (1320 aa)
	CC1G_03447	C-3 sterol dehydrogenase. (455 aa)
	CC1G_03436	Aldo-keto reductase. (413 aa)
	CC1G_03387	2,5-diketo-D-gluconic acid reductase. (317 aa)
	CC1G_07765	Uncharacterized protein. (411 aa)
	CC1G_06526	Uncharacterized protein. (228 aa)
	CC1G_06487	Uncharacterized protein. (181 aa)
	CC1G_06485	Uncharacterized protein. (181 aa)
	CC1G_09912	Uncharacterized protein. (290 aa)
	CC1G_09903	Uncharacterized protein. (295 aa)
	CC1G_09792	acidPPc domain-containing protein. (255 aa)
	CC1G_05813	Oxysterol-binding protein; Belongs to the OSBP family. (1172 aa)
	CC1G_11734	Conjugated polyketone reductase C1. (312 aa)
	CC1G_01585	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	CC1G_01518	Uncharacterized protein. (916 aa)
	CC1G_10826	CoCAF-1. (812 aa)
	CC1G_03868	SSD domain-containing protein. (1200 aa)
	CC1G_11764	PriB protein. (626 aa)
	CC1G_05164	Uncharacterized protein. (411 aa)
	CC1G_01124	Oxidoreductase. (290 aa)
	CC1G_01081	Uncharacterized protein. (603 aa)
	CC1G_07415	Uncharacterized protein. (318 aa)
	CC1G_10557	Uncharacterized protein. (208 aa)
	CC1G_11060	Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
	CC1G_07623	Uncharacterized protein. (207 aa)
	CC1G_11548	Uncharacterized protein. (845 aa)
	CC1G_02511	Multidrug resistance protein 1. (1327 aa)
	CC1G_10712	Glycerol dehydrogenase. (312 aa)
	CC1G_08364	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (528 aa)
	CC1G_05695	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (788 aa)
	CC1G_00893	Uncharacterized protein. (481 aa)
	CC1G_00827	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (473 aa)
	CC1G_03987	Squalene epoxidase. (538 aa)
	CC1G_03978	Squalene synthase. (514 aa)
	CC1G_09276	Uncharacterized protein. (295 aa)
	CC1G_02299	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (415 aa)
	CC1G_12642	2,5-didehydrogluconate reductase. (232 aa)
	CC1G_06875	ATP-binding cassette transporter. (732 aa)
	CC1G_06822	Aldehyde reductase 1. (341 aa)
	CC1G_15431	Uncharacterized protein. (220 aa)
	CC1G_15019	CAIB/BAIF family enzyme. (415 aa)
	CC1G_14953	3-oxo-5-alpha-steroid 4-dehydrogenase 1. (362 aa)
	CC1G_15513	Lipid A export ATP-binding/permease msbA. (561 aa)
	CC1G_14136	Uncharacterized protein. (339 aa)
	CC1G_14219	Mitochondrial half-size ABC transporter. (1138 aa)
	CC1G_13901	Uncharacterized protein. (332 aa)
	CC1G_09970	3-keto sterol reductase. (426 aa)
	CC1G_04855	Multidrug resistance protein 1. (1283 aa)
	CC1G_04827	Uncharacterized protein. (281 aa)
	CC1G_04826	Uncharacterized protein. (286 aa)
	CC1G_03119	Squalene monooxygenase. (485 aa)
	CC1G_10429	Uncharacterized protein. (473 aa)
	CC1G_09457	ABC transmembrane type-1 domain-containing protein. (734 aa)
	CC1G_09456	P-glycoprotein. (1117 aa)
	CC1G_11629	ABC transporter domain-containing protein. (380 aa)
	CC1G_05275	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1354 aa)
	CC1G_12756	Cytochrome P450; Belongs to the cytochrome P450 family. (305 aa)
	CC1G_02580	Farnesyldiphosphatesynthetase; Belongs to the FPP/GGPP synthase family. (402 aa)
	CC1G_12853	D-xylose reductase. (320 aa)
	CC1G_10414	Uncharacterized protein. (272 aa)
	CC1G_09664	Uncharacterized protein. (478 aa)
	CC1G_09662	Uncharacterized protein. (478 aa)
	CC1G_06695	Nuclear transcription factor Y. (242 aa)
	CC1G_07897	Cytochrome P450 11B1. (496 aa)

Your Current Organism:

Coprinopsis cinerea

NCBI taxonomy Id: 240176
Other names: C. cinerea okayama7#130, Coprinopsis cinerea okayama7#130, Coprinus cinereus okayama7#130

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CC1G_00827	CC1G_00893	A8N8V2	A8N918	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.531
CC1G_00827	CC1G_01585	A8N8V2	A8NI50	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.498
CC1G_00827	CC1G_02028	A8N8V2	A8N6C3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.545
CC1G_00827	CC1G_02299	A8N8V2	A8N7P2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.849
CC1G_00827	CC1G_02580	A8N8V2	A8PB79	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Farnesyldiphosphatesynthetase; Belongs to the FPP/GGPP synthase family.	0.784
CC1G_00827	CC1G_03119	A8N8V2	A8PF05	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Squalene monooxygenase.	0.811
CC1G_00827	CC1G_03447	A8N8V2	A8NQS0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	C-3 sterol dehydrogenase.	0.728
CC1G_00827	CC1G_03978	A8N8V2	A8N8D1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Squalene synthase.	0.924
CC1G_00827	CC1G_03987	A8N8V2	A8N8E0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Squalene epoxidase.	0.811
CC1G_00827	CC1G_04609	A8N8V2	A8N531	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Farnesyltranstransferase; Belongs to the FPP/GGPP synthase family.	0.719
CC1G_00827	CC1G_04738	A8N8V2	A8P2D6	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	C-4 methyl sterol oxidase; Belongs to the sterol desaturase family.	0.926
CC1G_00827	CC1G_04826	A8N8V2	A8PFQ1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.545
CC1G_00827	CC1G_04827	A8N8V2	A8PFQ2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.545
CC1G_00827	CC1G_05275	A8N8V2	A8PCG2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999
CC1G_00827	CC1G_05509	A8N8V2	A8P5J2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	C-14 sterol reductase.	0.639
CC1G_00827	CC1G_05514	A8N8V2	A8P5K0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	BHLH domain-containing protein.	0.458
CC1G_00827	CC1G_05695	A8N8V2	A8N9W8	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.773
CC1G_00827	CC1G_06409	A8N8V2	A8NTX3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Zn(2)-C6 fungal-type domain-containing protein.	0.498
CC1G_00827	CC1G_07605	A8N8V2	A8NUS3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family.	0.716
CC1G_00827	CC1G_07623	A8N8V2	A8NC19	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.545