STRINGSTRING
lysA lysA Ava_1080 Ava_1080 Ava_1084 Ava_1084 Ava_1090 Ava_1090 Ava_1133 Ava_1133 Ava_1171 Ava_1171 dapL2 dapL2 Ava_1670 Ava_1670 Ava_1766 Ava_1766 bioF bioF Ava_2838 Ava_2838 Ava_2839 Ava_2839 Ava_2899 Ava_2899 Ava_2996 Ava_2996 nifJ nifJ Ava_3052 Ava_3052 Ava_3117 Ava_3117 Ava_3533 Ava_3533 Ava_3695 Ava_3695 argD argD Ava_3855 Ava_3855 nifS1 nifS1 Ava_3985 Ava_3985 Ava_3986 Ava_3986 Ava_4036 Ava_4036 Ava_4077 Ava_4077 Ava_4101 Ava_4101 Ava_4108 Ava_4108 Ava_4114 Ava_4114 Ava_4155 Ava_4155 Ava_4157 Ava_4157 Ava_4173 Ava_4173 nifS2 nifS2 hisC1 hisC1 Ava_1795 Ava_1795 Ava_1826 Ava_1826 Ava_1933 Ava_1933 glyA glyA Ava_2127 Ava_2127 hisC2 hisC2 dapL1 dapL1 Ava_2590 Ava_2590 Ava_2591 Ava_2591 Ava_2592 Ava_2592 Ava_2593 Ava_2593 Ava_2595 Ava_2595 Ava_2749 Ava_2749 Ava_2757 Ava_2757 hemL hemL Ava_4856 Ava_4856 Ava_4744 Ava_4744 Ava_4745 Ava_4745 Ava_4747 Ava_4747 Ava_4749 Ava_4749 Ava_4750 Ava_4750 Ava_4834 Ava_4834 Ava_0017 Ava_0017 Ava_0122 Ava_0122 Ava_0159 Ava_0159 Ava_0214 Ava_0214 Ava_0390 Ava_0390 Ava_0427 Ava_0427 Ava_0437 Ava_0437 Ava_4742 Ava_4742 menD menD dxs dxs ilvA ilvA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (464 aa)
Ava_1080Ferredoxin (flavodoxin) oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. (1190 aa)
Ava_1084Alpha-glucan phosphorylase. (737 aa)
Ava_1090Aminotransferase. (450 aa)
Ava_1133Radical SAM. (656 aa)
Ava_1171Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (392 aa)
dapL2LL-diaminopimelate aminotransferase apoenzyme; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (390 aa)
Ava_1670RP ribonucleotide reductase-like protein. (765 aa)
Ava_1766L-threonine O-3-phosphate decarboxylase. (367 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (386 aa)
Ava_2838L-2,4-diaminobutyrate decarboxylase. (522 aa)
Ava_2839Diaminobutyrate aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (493 aa)
Ava_2899Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (222 aa)
Ava_2996Alpha-glucan phosphorylase. (854 aa)
nifJFerredoxin (flavodoxin) oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase. (1190 aa)
Ava_3052Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa)
Ava_3117L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (363 aa)
Ava_3533Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. (547 aa)
Ava_3695L-aspartate aminotransferase apoenzyme. (391 aa)
argDAcetylornithine aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (427 aa)
Ava_3855Amino acid adenylation; Belongs to the ATP-dependent AMP-binding enzyme family. (888 aa)
nifS1Aromatic amino acid beta-eliminating lyase/threonine aldolase; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation. (400 aa)
Ava_3985Short-chain dehydrogenase/reductase SDR. (2551 aa)
Ava_3986Short-chain dehydrogenase/reductase SDR. (1874 aa)
Ava_4036Prolyl 4-hydroxylase, alpha subunit. (224 aa)
Ava_4077O-acetylhomoserine sulfhydrolase. (434 aa)
Ava_4101Amino acid adenylation. (1345 aa)
Ava_4108Beta-ketoacyl synthase. (1656 aa)
Ava_4114Thiamine pyrophosphate enzyme. (541 aa)
Ava_4155Cystathionine gamma-lyase. (378 aa)
Ava_4157Aminotransferase. (204 aa)
Ava_4173Conserved hypothetical protein. (203 aa)
nifS2Aromatic amino acid beta-eliminating lyase/threonine aldolase; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation. (398 aa)
hisC1Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa)
Ava_1795Cobalamin B12-binding protein. (529 aa)
Ava_1826Cysteine desulfurase related protein. (457 aa)
Ava_1933Transcriptional regulator, GntR family. (490 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
Ava_2127Aminotransferase. (388 aa)
hisC2Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (380 aa)
dapL1LL-diaminopimelate aminotransferase apoenzyme; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa)
Ava_2590Beta-ketoacyl synthase. (1764 aa)
Ava_2591Short-chain dehydrogenase/reductase SDR. (611 aa)
Ava_2592Beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (453 aa)
Ava_2593Beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (1109 aa)
Ava_2595Thioester reductase. (506 aa)
Ava_2749Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (329 aa)
Ava_2757Acetolactate synthase, large subunit. (632 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (432 aa)
Ava_4856Aromatic amino acid beta-eliminating lyase/threonine aldolase. (389 aa)
Ava_4744Short-chain dehydrogenase/reductase SDR. (491 aa)
Ava_4745Beta-ketoacyl synthase. (1587 aa)
Ava_4747Beta-ketoacyl synthase. (1272 aa)
Ava_4749Short-chain dehydrogenase/reductase SDR. (584 aa)
Ava_4750Beta-ketoacyl synthase. (1605 aa)
Ava_4834Beta-ketoacyl synthase. (1646 aa)
Ava_0017LL-diaminopimelate aminotransferase apoenzyme. (403 aa)
Ava_0122MOSC. (262 aa)
Ava_0159Aminotransferase. (407 aa)
Ava_02144-aminobutyrate aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (431 aa)
Ava_0390Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (395 aa)
Ava_0427Cysteine desulfurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (420 aa)
Ava_0437Aromatic amino acid beta-eliminating lyase/threonine aldolase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (388 aa)
Ava_4742Beta-ketoacyl synthase. (1144 aa)
menD2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (587 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (635 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (503 aa)
Your Current Organism:
Trichormus variabilis
NCBI taxonomy Id: 240292
Other names: Anabaena flos-aquae A-37, Anabaena flos-aquae UTCC 67, Anabaena sp. CCALA 007, Anabaena sp. PCC 7937, Anabaena variabilis ATCC 29413, Anabaena variabilis IAM M-204, Anabaena variabilis NIES-2095, Anabaena variabilis UTCC 105, Nostoc sp. PCC 7937, T. variabilis ATCC 29413, Trichormus variabilis ATCC 29413
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